Patents by Inventor Curtis R. Kautzer

Curtis R. Kautzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for amplification of nucleic acids
    Patent number: 6740510
    Abstract: The presently claimed invention provides methods for amplifying a DNA target sequence. One embodiment of the present invention provides robust methods for amplification of target sequences. In a first aspect of the invention, a method for designing primer pairs for the amplification reaction is provided. In a further aspect of the invention, reagents and cycling parameters for the amplification reaction are provided.
    Type: Grant
    Filed: January 9, 2002
    Date of Patent: May 25, 2004
    Assignee: Perlegen Sciences, Inc.
    Inventors: Curtis R. Kautzer, Nila Patil, Coleen R. Hacker, David P. McDonough
  • Increased throughput analysis of small compounds using multiple temporally spaced injections
    Patent number: 6533912
    Abstract: The apparatus and method of the present invention disclose a system in which multiple injections may be made into a capillary array. The injections are spaced in time with each injection followed by an interval of electrophoresis. Once all samples are loaded into the capillaries, continuous electrophoresis and detection is used to separate and detect target compounds within the sample. The interval between injections is matched to the target compound migration rate to be sufficient to allow the target compounds to be detectably separated when the compounds reach the detector.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: March 18, 2003
    Assignee: Molecular Dynamics, Inc.
    Inventors: Elaine S. Mansfield, Christine Peponnet, John S. Bashkin, Curtis R. Kautzer
  • Increased throughput analysis of small compounds using multiple temporally spaced injections
    Patent number: 6156178
    Abstract: The apparatus and method of the present invention disclose a system in which multiple injections may be made into a capillary array. The injections are spaced in time with each injection followed by an interval of electrophoresis. Once all samples are loaded into the capillaries, continuous electrophoresis and detection is used to separate and detect target compounds within the sample. The interval between injections is matched to the target compound migration rate to be sufficient to allow the target compounds to be detectably separated when the compounds reach the detector.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: December 5, 2000
    Assignee: Molecular Dynamics, Inc.
    Inventors: Elaine S. Mansfield, Christine Peponnet, John S. Bashkin, Curtis R. Kautzer
  • Method for using a quality metric to assess the quality of biochemical separations
    Patent number: 6019896
    Abstract: A method for performing separation assays of biochemical samples includes computing a quality metric based on peak data produced during the separation run. The quality metric is the basis for selecting a subsequent step in the assay, including whether to re-run the separation when the quality metric indicates a low quality separation run. In a preferred embodiment, the quality metric is computed based on a peak resolution metric indicative of the peak resolution of the sample peaks in the data and a signal-to-noise ratio of the data. When a co-migrating standard is included in the separation run, the quality metric is further based on the degree of migration linearity of the reference peaks produced by the standard. The method was reduced to practice in separations to size and sort DNA fragments in high-throughput capillary array electrophoresis separations.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: February 1, 2000
    Assignee: Molecular Dynamics, Inc.
    Inventors: Elaine S. Mansfield, Lian-She Zhao, Marina Vainer, Curtis R. Kautzer