Abstract: A medical system tracks the position of a medical instrument within a body of a patient. The medical instrument includes an elongated flexible printed circuit and an electromagnet structure having a conductive coil wound around a core. A control circuit applies an excitation signal across the conductive coil. Electrical current running through the conductive coil (wound around the core) generates a magnetic field. A plurality of sensors sense parameters of the magnetic field and output sensor signals. The control circuit calculates the position of the medical instrument based on the sensor signals.

Abstract: A multipart connector is employed in a system that tracks a medical device in the human body. The multipart connector includes a first connector portion and a second connector portion wherein the first connector portion pierces a contamination barrier to couple with the second connector portion. The medical device is a trackable structure having an integrated electromagnet circuit. The trackable structure is arranged to controllably produce a magnetic field. An interface is provided in the system to produce a positional representation of the trackable structure when the trackable structure is placed and moved within the human body. A magnetic field sensing device drives the integrated electromagnet circuit of the trackable structure tracks medical device and provides position information to the interface. The multipart connector electrically couples the magnetic field sensing device to the trackable structure.

Abstract: A scope having a plurality of range-dependent, point-of-impact indicators (aim points), and methods for use of that scope. Such aim points are superimposed on the user's field of view of a conventional scope. A preferred embodiment may be coupled to a conventional scope. Embodiments include an auxiliary light projector that presents at least one aim point disposed in a user's field of view, and the aim point(s) is/are adjustable for elevation and windage. Aim points may also be adjusted in size, color, shape, and intensity.

Abstract: A support structure device is configured to assist a human patient to rise. The support structure includes a tube bent into a shape described by way of a reference frustum such as a four-sided truncated pyramid. Each side of a top rectangular perimeter of the frustum is shorter than a corresponding side of the bottom rectangular perimeter, and each parallel side of a first trapezoidal perimeter of the frustum is shorter than a corresponding parallel side of a second trapezoidal perimeter. The reference frustum has a height between 10 and 18 inches, the top rectangular perimeter has a length between 10 and 16 inches and a width between 6 and 14 inches, and the bottom rectangular perimeter has a length between 12 and 18 inches and a width between 8 and 16 inches.

Abstract: A medical instrument guiding device includes a body base component, and a guide body upper component assembled to the body base component. The guide body upper component has a substantially semi-spherical shape to house a medical instrument guide ball resting on a friction surface located within the body base component. The surface of the guide body upper component includes a cut out working area, and a surface of the medical instrument guide ball is exposed by the cut out working area. A medical instrument port is arranged on a truncated surface of the medical instrument guide ball, and a medical instrument may be passed through the medical instrument port. The medical instrument guide ball permits the medical instrument to be moved in three dimensions. The medical instrument port permits the medical instrument to be advanced into a patient.

Abstract: Therapeutic application of mild to moderate hypothermia in a medical procedure has been found to provide benefits to patients. For example, application of mild hypothermia in the auditory pathway can prevent functional hearing loss post cochlear implant surgery. Devices have been conceived and reduced to practice that apply localized cooling to a small area such as the basal or middle turn of the cochlea. The devices include a cooling tip with at least one thermo-conductive surface. A heat-transporting fluid is circulated through the cooling tip.

Abstract: An endoscopic device having a one-handed, either-handed steering mechanism is presented. The endoscopic device includes some components that are sterile and used on only a single patient. The single-use components are medically disposed of after exposure to a non-sterile environment such as an internal body cavity of a patient. The endoscopic device also includes some reusable components that are not exposed to a non-sterile environment.

Abstract: An endoscopic device has a tubular body with a retention channel substantially extending axially along the tube body. A medical tube is removably arranged in the retention channel and held in place by friction. A cable assembly is arranged between the medical tube and the surface of the retention channel. The cable assembly includes a shaped end fixture that is drawn between the medical tube and the retention channel when the cable is pulled, thereby releasing the medical tube from the tube body.

Abstract: A method to manufacture microfluidic sensors 100, 100?, 132, 280, 380, includes stacking a plurality of layers of material to form at least a first cap layer 102, a first channel layer 104, an interrogation layer 106, and a second channel layer 108. During assembly, ribbon sections of substrate layers are sandwiched to cooperatively align elements through-the-thickness of the sandwich. Individual sensors are then removed from the sandwich ribbon 504. A componentizing step includes forming one or more element for successive sensors spaced along the axial length of a ribbon of substrate material. Certain elements include electrically conductive patterned structures 250 printed onto a substrate using conductive ink and a printing process. Sometimes, the printing process places material in operable position to conduct electricity through the thickness of at least one ribbon. Other elements may include channels 112, 116; tunnels 114, and vias 260, 268.

Abstract: A medical instrument guiding device includes a body base component, and a guide body upper component assembled to the body base component. The guide body upper component has a substantially semi-spherical shape to house a medical instrument guide ball resting on a friction surface located within the body base component. The surface of the guide body upper component includes a cut out working area, and a surface of the medical instrument guide ball is exposed by the cut out working area. A medical instrument port is arranged on a truncated surface of the medical instrument guide ball, and a medical instrument may be passed through the medical instrument port. The medical instrument guide ball permits the medical instrument to be moved in three dimensions. The medical instrument port permits the medical instrument to be advanced into a patient.

Abstract: A method to manufacture microfluidic sensors 100, 100?, 132, 280, 380, includes stacking a plurality of layers of material to form at least a first cap layer 102, a first channel layer 104, an interrogation layer 106, and a second channel layer 108. During assembly, ribbon sections of substrate layers are sandwiched to cooperatively align elements through-the-thickness of the sandwich. Individual sensors are then removed from the sandwich ribbon 504. A componentizing step includes forming one or more element for successive sensors spaced along the axial length of a ribbon of substrate material. Certain elements include electrically conductive patterned structures 250 printed onto a substrate using conductive ink and a printing process. Sometimes, the printing process places material in operable position to conduct electricity through the thickness of at least one ribbon. Other elements may include channels 112, 116; tunnels 114, and vias 260, 268.

Abstract: A method to manufacture microfluidic sensors, typically including componentizing substrate layers One such method includes providing a plurality of layers of material configured to permit their stacking to form at least a first cap layer, a first channel layer, an interrogation layer, and a second channel layer During assembly, ribbon sections of substrate layers are sandwiched to cooperatively align elements through-the-thickness of the sandwich Individual sensors are then removed from the sandwich ribbon A componentizing step includes forming one or more elements for successive sensors spaced along the axial length of a ribbon Certain elements include electrically conductive patterned structures preferably printed onto a substrate using conductive ink and a printing process, sometimes placing material in operable position to conduct electricity through the thickness of at least one nbbon Other elements may include channels, tunnels, and vias that can be machined, stamped, or cut into a ribbon section.

Abstract: An apparatus for detecting particles of interest that are dispersed in a fluid mix, which typically includes other particles. The apparatus typically is associated with an interrogation platform arranged to operate in harmony with an opaque member having an orifice sized to promote single-file travel of the particles there-through. A currently preferred embodiment includes a light pipe configured to impinge stimulation-radiation substantially transverse to a direction of fluid flow through the opaque member. Particles of interest may be tagged using antibody-binding, fluorescing molecules. Stimulation radiation from the source causes the tagged particles to undergo a Stokes-shift emission of fluorescence. The resulting fluorescence is detected by the radiation detector and indicates passage of the particles of interest. One workable opaque member is advantageously included in a thin film assembly carried on a removable and disposable card that is adapted for reception in the interrogation platform.

Abstract: An improved pipette tip (100) including an elongate body stretching between a proximal end (116) and a distal end (114). The body (112) is typically made from a plurality of layers (e.g. 130, 132, 134, 136, 138) configured and arranged to provide a fluid path extending from the distal end toward the proximal end. The improved pipette tip (100) includes a sensor component disposed to electrically interrogate fluid flowing along the fluid path. An operable sensor component includes an electrode (e.g. 154, 192) that is disposed in the fluid path to contact fluid therein. A pipette tip (100) may be embodied to: count particles, verify sample integrity (e.g. freedom from bubbles), monitor sample flow rate, and confirm an inspired volume, among other uses.

Abstract: A biological particle manipulating device and method of its use. The device includes structure arranged to urge biological particles into substantially single file travel through an interrogation zone. Operable alignment structure nonexclusively include sheathed fluid flow, capillary tubes, an orifice, and fluid microchannels. One or more detector, selected from a plurality of operable such structures, may be employed to sense the presence of a biologic particle in the interrogation zone. Certain exemplary detectors may operate on the Coulter principle, or may detect a Stokes' shift, or side-scatter radiation. Discrimination structure is generally provided to categorize particles as being in one or another sub-population of a mix of biological particles that may be carried in a fluid sample, such as by cell type, size, or the like.

Abstract: A biological particle sorting device and method of its use. The device includes structure arranged to urge biological particles into substantially single file travel through an interrogation zone. Operable alignment structure nonexclusively include sheathed fluid flow, capillary tubes, an orifice, and fluid microchannels. One or more detector, selected from a plurality of operable such structures, may be employed to sense the presence of a biologic particle in the interrogation zone. Certain exemplary detectors may operate on the Coulter principle, or may detect a Stokes' shift, or side-scatter radiation. Discrimination structure is generally provided to categorize particles as being in one or another sub-population of a mix of biological particles that may be carried in a fluid sample, such as by cell type, size, or the like. Killing structure, such as a laser, is disposed to neutralize all particles in any undesired sub-population while leaving undamaged the desired sub-population(s).

Abstract: A method to manufacture microfluidic sensors, typically including componentizing substrate layers One such method includes providing a plurality of layers of material configured to permit their stacking to form at least a first cap layer, a first channel layer, an interrogation layer, and a second channel layer During assembly, ribbon sections of substrate layers are sandwiched to cooperatively align elements through-the-thickness of the sandwich Individual sensors are then removed from the sandwich ribbon A componentizing step includes forming one or more elements for successive sensors spaced along the axial length of a ribbon Certain elements include electrically conductive patterned structures preferably printed onto a substrate using conductive ink and a printing process, sometimes placing material in operable position to conduct electricity through the thickness of at least one nbbon Other elements may include channels, tunnels, and vias that can be machined, stamped, or cut into a ribbon section.

Abstract: An improved pipette tip (276) including an elongate body stretching between a proximal end (277) and a distal end. The body typically includes a plurality of thin film layers (e.g. 154, 156, 102, 158, 202) configured and arranged to provide a fluid path extending from the distal end toward the proximal end (277). The improved pipette tip (276) includes an interrogation zone in which to interrogate fluid flowing along the fluid path. One operable interrogation arrangement, generally (100), includes structure configured to permit detection of radiation resulting from a Stokes-shift. Optionally, a sensor component may include one or more electrode (e.g. 248, 250) that is disposed in the fluid path to contact fluid therein for electrically-based interrogation. A pipette tip (276) may be embodied to: count particles, verify sample integrity (e.g. freedom from bubbles), monitor sample flow rate, and confirm an inspired volume, among other uses.

Abstract: An improved pipette tip (100) including an elongate body stretching between a proximal end (116) and a distal end (114). The body (112) is typically made from a plurality of layers (e.g. 130, 132, 134, 136, 138) configured and arranged to provide a fluid path extending from the distal end toward the proximal end. The improved pipette tip (100) includes a sensor component disposed to electrically interrogate fluid flowing along the fluid path. An operable sensor component includes an electrode (e.g. 154, 192) that is disposed in the fluid path to contact fluid therein. A pipette tip (100) may be embodied to: count particles, verify sample integrity (e.g. freedom from bubbles), monitor sample flow rate, and confirm an inspired volume, among other uses.

Abstract: An apparatus for detecting particles of interest that are dispersed in a fluid mix, which typically includes other particles. The apparatus typically is associated with an interrogation platform arranged to operate in harmony with an opaque member having an orifice sized to promote single-file travel of the particles there-through. A currently preferred embodiment includes a light pipe configured to impinge stimulation-radiation substantially transverse to a direction of fluid flow through the opaque member. Particles of interest may be tagged using antibody-binding, fluorescing molecules. Stimulation radiation from the source causes the tagged particles to undergo a Stokes-shift emission of fluorescence. The resulting fluorescence is detected by the radiation detector and indicates passage of the particles of interest. One workable opaque member is advantageously included in a thin film assembly carried on a removable and disposable card that is adapted for reception in the interrogation platform.