Patents by Inventor Curtiss P. Schneider

Curtiss P. Schneider has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dendrimer-based excipients for the attenuation of protein aggregation
    Patent number: 9410142
    Abstract: One aspect of the invention is a salt comprising guanidinium groups, as shown in formula I. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula II. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula III. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula IV. Yet another aspect of the invention is a salt comprising guanidinium groups, as shown in formula I, II, III, and IV further comprising independently for each occurrence citrate, phosphate, or sulfate anion. Also disclosed are compositions comprising a protein and a salt comprising guanidinium groups, as shown in formula I, II, III, and IV. Also provided are methods of increasing shelf life of an aqueous solution of a protein and decreasing the amount of protein aggregation in an aqueous solution of a protein.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: August 9, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Bernhardt L. Trout, II, Diwakar Shukla, Curtiss P. Schneider
  • Dendrimer-Based Excipients for the Attenuation of Protein Aggregation
    Publication number: 20140004592
    Abstract: One aspect of the invention is a salt comprising guanidinium groups, as shown in formula I. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula II. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula III. Another aspect of the invention is a salt comprising guanidinium groups, as shown in formula IV. Yet another aspect of the invention is a salt comprising guanidinium groups, as shown in formula I, II, III, and IV further comprising independently for each occurrence citrate, phosphate, or sulfate anion. Also disclosed are compositions comprising a protein and a salt comprising guanidinium groups, as shown in formula I, II, III, and IV. Also provided are methods of increasing shelf life of an aqueous solution of a protein and decreasing the amount of protein aggregation in an aqueous solution of a protein.
    Type: Application
    Filed: November 11, 2011
    Publication date: January 2, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Bernhardt L. Trout, II, Diwakar Shukla, Curtiss P. Schneider