Patents by Inventor Cymbeline T. Culiat

Cymbeline T. Culiat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for regenerating tissues
    Patent number: 11891424
    Abstract: Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: February 6, 2024
    Assignee: NellOne Therapeutics, Inc.
    Inventor: Cymbeline T. Culiat
  • Methods and compositions for regenerating tissues
    Patent number: 11667684
    Abstract: Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: June 6, 2023
    Assignee: NellOne Therapeutics, Inc.
    Inventor: Cymbeline T. Culiat
  • METHODS AND COMPOSITIONS FOR TREATING MUSCLE ATROPHY
    Publication number: 20230121387
    Abstract: Provided are methods of treating muscle atrophy by administering a NELL1 polypeptide, or a nucleic acid molecule encoding a NELL1 polypeptide, to a subject in need thereof. Such subjects include pediatric subjects, cancer patients, patients with relatively high circulating levels of interleukin-1 beta (IL-1?), and patients suffering from chronic systemic inflammation, particularly inflammation associated with interleukin-1 beta (IL-1?).
    Type: Application
    Filed: March 5, 2021
    Publication date: April 20, 2023
    Applicant: NELLONE THERAPEUTICS, INC.
    Inventors: CYMBELINE T. CULIAT, SHANNON STEWART EAKER
  • METHODS AND COMPOSITIONS FOR TREATING TISSUE DAMAGE RESULTING FROM VIRAL INFECTIONS
    Publication number: 20230116082
    Abstract: Provided are methods of treating virally-induced tissue damage (e.g., lung tissue damage, heart tissue and/or vasculature damage, skeletal muscle damage) and/or inflammation by administering a NELL1 polypeptide, or a nucleic acid molecule encoding a NELL1 polypeptide, to a subject in need thereof.
    Type: Application
    Filed: March 5, 2021
    Publication date: April 13, 2023
    Applicant: NELLONE THERAPEUTICS, INC.
    Inventors: CYMBELINE T. CULIAT, SHANNON STEWART EAKER
  • METHODS AND COMPOSITIONS FOR REGENERATING TISSUES
    Publication number: 20220281932
    Abstract: Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
    Type: Application
    Filed: May 20, 2022
    Publication date: September 8, 2022
    Applicant: NELLONE THERAPEUTICS, INC.
    Inventor: CYMBELINE T. CULIAT
  • METHODS AND COMPOSITIONS FOR REGENERATING TISSUES
    Publication number: 20210355179
    Abstract: Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
    Type: Application
    Filed: May 28, 2021
    Publication date: November 18, 2021
    Applicant: NELLONE THERAPEUTICS, INC.
    Inventor: CYMBELINE T. CULIAT
  • Methods and compositions for regenerating tissues
    Patent number: 11034741
    Abstract: Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: June 15, 2021
    Assignee: NellOne Therapeutics, Inc.
    Inventor: Cymbeline T. Culiat
  • Methods and compositions for regenerating tissues
    Patent number: 10752663
    Abstract: Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: August 25, 2020
    Assignee: NELLONE THERAPEUTICS, INC.
    Inventor: Cymbeline T. Culiat
  • METHODS AND COMPOSITIONS FOR REGENERATING TISSUES
    Publication number: 20200199184
    Abstract: Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
    Type: Application
    Filed: March 9, 2020
    Publication date: June 25, 2020
    Applicant: NELLONE THERAPEUTICS, INC.
    Inventor: CYMBELINE T. CULIAT
  • Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1
    Patent number: 9920104
    Abstract: The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: March 20, 2018
    Assignee: UT-Battelle, LLC
    Inventor: Cymbeline T. Culiat
  • METHODS AND COMPOSITIONS FOR REGENERATING TISSUES
    Publication number: 20180057550
    Abstract: Provided are methods for promoting the healing of injuries to tendons and ligaments by administering a NELL1 protein or a nucleic acid encoding a NELL1 protein to a subject in need thereof. Also provided are NELL1 compositions and methods for promoting tissue regeneration, promoting the healing of wounds, and enhancing fibroblast migration, proliferation, or both migration and proliferation.
    Type: Application
    Filed: August 29, 2017
    Publication date: March 1, 2018
    Applicant: NELLONE THERAPEUTICS, INC.
    Inventor: CYMBELINE T. CULIAT
  • Methods for Promoting Wound Healing and Muscle Regeneration with the Cell Signaling Protein Nell1
    Publication number: 20150037294
    Abstract: The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.
    Type: Application
    Filed: September 25, 2014
    Publication date: February 5, 2015
    Inventor: Cymbeline T. Culiat
  • Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1
    Patent number: 8877176
    Abstract: The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: November 4, 2014
    Assignee: UT-Battelle, LLC
    Inventor: Cymbeline T. Culiat
  • Treatment of Cardiovascular Disorders Using the Cell Differentiation Signaling Protein Nell1
    Publication number: 20140205577
    Abstract: It has been identified in accordance with the present invention that Nell1 is essential for normal cardiovascular development by promoting proper formation of the heart and blood vessels. The present invention therefore provides therapeutic methods for treating cardiovascular disorders by employing a Nell1 protein or nucleic acid molecule.
    Type: Application
    Filed: April 1, 2014
    Publication date: July 24, 2014
    Applicant: UT-Battelle, LLC
    Inventor: Cymbeline T. Culiat
  • Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1
    Patent number: 8722625
    Abstract: It has been identified in accordance with the present invention that Nell1 is essential for normal cardiovascular development by promoting proper formation of the heart and blood vessels. The present invention therefore provides therapeutic methods for treating cardiovascular disorders by employing a Nell1 protein or nucleic acid molecule.
    Type: Grant
    Filed: September 24, 2008
    Date of Patent: May 13, 2014
    Assignee: UT-Battelle, LLC
    Inventor: Cymbeline T. Culiat
  • METHODS FOR PROMOTING WOUND HEALING AND MUSCLE REGENERATION WITH THE CELL SIGNALING PROTEIN NELL1
    Publication number: 20110250186
    Abstract: The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.
    Type: Application
    Filed: February 17, 2011
    Publication date: October 13, 2011
    Applicant: UT-BATTELLE, LLC
    Inventor: Cymbeline T. Culiat
  • METHODS TO TREAT OR PREVENT A SKIN CONDITION USING A NELL1 PEPTIDE
    Publication number: 20110236325
    Abstract: The described invention provides methods and compositions utilizing a NELL1 peptide or nucleic acid encoding a NELL1 peptide for treating or preventing a skin condition. The methods include treating or preventing manifestations of aging in human skin, repairing damage to skin, and preventing skin scarring. Methods are also provided for assaying a test peptide for NELL1 activity.
    Type: Application
    Filed: January 21, 2011
    Publication date: September 29, 2011
    Applicant: NellOne Therapeutics, Inc.
    Inventors: Dora P. Mitchell, Cymbeline T. Culiat, Beverly W. Lubit
  • Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1
    Patent number: 7910542
    Abstract: The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: March 22, 2011
    Assignee: UT-Battelle, LLC
    Inventor: Cymbeline T. Culiat
  • DIAGNOSIS AND TREATMENT OF CONGENITAL HEART DEFECTS USING NELL1
    Publication number: 20110002893
    Abstract: The present invention provides diagnostic methods for detecting congenital heart defects, or increased risk thereof, based on the Nell1 gene, RNA and protein. The methods include obtaining a biological sample and assessing the presence of a mutation in the Nell1 gene, RNA or protein. The presence of a mutation in the Nell1 gene, RNA or protein can be assessed by determining the levels of Nell1 gene, RNA or protein in the biological sample. The present invention further provides therapeutic methods for treating congenital heart defects based on the Nell1 gene. RNA and protein.
    Type: Application
    Filed: November 3, 2009
    Publication date: January 6, 2011
    Applicant: UT-BATTELLE, LLC
    Inventor: Cymbeline T. Culiat
  • Diagnosis and Treatment of Congenital Heart Defects Using NELL1
    Publication number: 20100273713
    Abstract: The present invention provides diagnostic methods for detecting congenital heart defects, or increased risk thereof, based on the Nell1 gene, RNA and protein. The methods include obtaining a biological sample and assessing the presence of a mutation in the Nell1 gene, RNA or protein. The presence of a mutation in the Nell1 gene, RNA or protein can be assessed by determining the levels of Nell1 gene, RNA or protein in the biological sample. The present invention further provides therapeutic methods for treating congenital heart defects based on the Nell1 gene, RNA and protein.
    Type: Application
    Filed: April 30, 2010
    Publication date: October 28, 2010
    Applicant: UT-BATTELLE, LLC
    Inventor: Cymbeline T. Culiat