Patents by Inventor Cynthia A. Hale

Cynthia A. Hale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11166676
    Abstract: This medical device measures blood flow rate through the renal artery after a kidney transplant in real time. The device utilizes a force sensing resistor (FSR) to detect the amount of blood and the given blood pressure at any instantaneous point in time. The FSR wraps around the renal artery after transplantation and should remain connected for five to seven days for optimal kidney blood flow and kidney functioning detection. This will be achieved by measuring the flow rate, estimating blood pressure, and beats per minute this device should alert doctors if irregular kidney function should occur for fast and immediate surgical or bedside intervention. Our goal is to detect post-transplant kidney rejection in real-time. The device is biocompatible and sterile, easily removed from the renal artery, and smaller than 5 mm in diameter.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: November 9, 2021
    Inventors: Marina I. Adrianzen Fonseca, Saisanjana Kalagara, Regine Rosas, Cynthia Hale-Phillips
  • Publication number: 20190175113
    Abstract: This medical device measures blood flow rate through the renal artery after a kidney transplant in real time. The device utilizes a force sensing resistor (FSR) to detect the amount of blood and the given blood pressure at any instantaneous point in time. The FSR wraps around the renal artery after transplantation and should remain connected for five to seven days for optimal kidney blood flow and kidney functioning detection. This will be achieved by measuring the flow rate, estimating blood pressure, and beats per minute this device should alert doctors if irregular kidney function should occur for fast and immediate surgical or bedside intervention. Our goal is to detect post-transplant kidney rejection in real-time. The device is biocompatible and sterile, easily removed from the renal artery, and smaller than 5 mm in diameter.
    Type: Application
    Filed: December 11, 2017
    Publication date: June 13, 2019
    Inventors: Marina I. Adrianzen Fonseca, Saisanjana Kalagara, Regine Rosas, Cynthia Hale-Phillips
  • Patent number: 7326566
    Abstract: A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means (e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: February 5, 2008
    Assignee: Case Western Reserve University
    Inventors: Piet A. J. de Boer, Cynthia A. Hale
  • Publication number: 20050059058
    Abstract: A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means (e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
    Type: Application
    Filed: July 29, 2004
    Publication date: March 17, 2005
    Inventors: Piet de Boer, Cynthia Hale
  • Patent number: 6809180
    Abstract: A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein—protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means (e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: October 26, 2004
    Assignee: Case Western Reserve University
    Inventors: Piet A. J. de Boer, Cynthia A. Hale
  • Publication number: 20030096953
    Abstract: A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means (e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
    Type: Application
    Filed: April 11, 2001
    Publication date: May 22, 2003
    Applicant: Case Western Reserve University
    Inventors: Piet A. J. de Boer, Cynthia A. Hale
  • Publication number: 20030040043
    Abstract: The present invention relates to the ZipA-binding site of FtsZ, as determined using genetic and mutagenesis techniques. In particular, the present invention provides a ZipA-binding site of FtsZ, and a molecule having a ZipA-binding site. Also disclosed are mutant FtsZ proteins. The present invention is further directed to a method for identifying an agent which interacts with FtsZ, as well as an agent that interacts with FtsZ at a binding site. Finally, the present invention discloses a method for identifying an agent that interacts with a molecule having a ZipA-binding site, as well as an agent that interacts with a molecule having a ZipA-binding site.
    Type: Application
    Filed: July 18, 2001
    Publication date: February 27, 2003
    Inventors: Steven Haney, Cynthia Hale, Piet de Boer, Elizabeth Glasfeld
  • Patent number: 6248543
    Abstract: A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means (e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: June 19, 2001
    Assignee: Case Western Reserve University
    Inventors: Piet A. J. de Boer, Cynthia A. Hale
  • Patent number: 5948889
    Abstract: A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means (e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: September 7, 1999
    Assignee: Case Western Reserve University
    Inventors: Piet A. J. de Boer, Cynthia A. Hale