Abstract: A handheld dust-removing device, including a main body to remove at least one particle of dust disposed on a surface of an air conditioning filter, and a handle at least partially disposed within at least a portion of the main body to allow a user to move the main body across the surface of an air conditioning filter to remove the at least one particle of dust.

Abstract: A handheld dust-removing device, including a main body to remove at least one particle of dust disposed on a surface of an air conditioning filter, and a handle at least partially disposed within at least a portion of the main body to allow a user to move the main body across the surface of an air conditioning filter to remove the at least one particle of dust.

Abstract: Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a “snapshot” of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these “static” and “dynamic” characterizations. The phenotype may be characterized by at least the following features: mitotic arrest characterized (i) chromosomes well-aligned at the metaphase plate and (ii) chromosome residence time at the metaphase plate substantially longer than that of a control cell or cell population. The phenotype may be further characterized by: during interphase the cell or population of cells exhibits a phenotype that is substantially similar to that of the interphase cells of the control cell or cell population.

Abstract: According to the present invention, computer based techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, computer based techniques for determining information about the properties of substances based upon information about structure of living or non-living cells exposed to substances are provided. Computer software according to the present invention enables researchers and/or scientists to identify promising candidates in the search for new and better medicines or treatments using, for example, a cellular informatics database.

Abstract: Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.

Abstract: Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.

Abstract: According to the present invention, computer based techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, computer based techniques for determining information about the properties of substances based upon information about structure of living or non-living cells exposed to substances are provided. Computer software according to the present invention enables researchers and/or scientists to identify promising candidates in the search for new and better medicines or treatments using, for example, a cellular informatics database.

Abstract: Compounds useful for treating cellular proliferative diseases are disclosed.

Abstract: A method for generating stimulus response curves (e.g., dose response curves) shows how the phenotype of one or more cells change in response to varying levels of the stimulus. Each “point” on the curve represents quantitative phenotype for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The quantitative phenotypes are multivariate phenotypic representations of the cell(s). They include various features of the cell(s) obtained by image analysis. Such features often include basic parameters obtained from images (e.g., cell shape, nucleus area, Golgi texture) and/or biological characterizations derived from the basic parameters (e.g., cell cycle state, mitotic index, etc.). The stimulus response curves may be compared to allow classification of stimuli and identify subtle differences in related stimuli. To facilitate the comparison, it may be desirable to present the response curves in a principal component space.

Abstract: Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a “snapshot” of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these “static” and “dynamic” characterizations. The phenotype may be characterized by at least the following features: (a) chromosomes that approach metaphase but fail to separate and maintain alignment compared to a control cell or cell population; (b) a bipolar spindle that is at least about 10% longer than a corresponding metaphase mitotic spindle from the control cell or cell population; and (c) during interphase the cell or population of cells exhibits a phenotype that is substantially similar to that of the interphase cells of the control cell or cell population.

Abstract: Compounds useful for treating cellular proliferative diseases are disclosed.

Abstract: Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.

Abstract: Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.