Patents by Inventor Cynthia B. Perz
Cynthia B. Perz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8582924Abstract: Disclosed is an imaging system that stores and retrieves very large scanned digital images, as in applications that automatically scan biological samples using a computer-controlled digital camera microscope. Slide data is entered, zelle data is captured and compressed and a zelle database file is loaded. Furthermore, an image database file is loaded and it is determined whether another zelle is to be stored. The image can be retrieved by accessing the zelle database, reading a zelle record, reading an image file, loading the display buffer, and determining whether another zelle is to be loaded.Type: GrantFiled: June 30, 2004Date of Patent: November 12, 2013Assignee: Carl Zeiss MicroImaging GmbHInventors: Jose De La Torre-Bueno, Cynthia B. Perz
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Patent number: 8369591Abstract: Systems and techniques to acquire image data. In general, in one implementation, the technique includes: acquiring image data for a plurality of areas of a scan region. The technique may further include processing the image data to determine whether an area includes one or more desired features. The technique may further include designating an area as “interesting” if it includes a desired feature, and designating an area as non-interesting if it does not include the desired feature. The areas may be sub-divided one or more times, and subdivisions may be analyzed to determine if they include a desired feature.Type: GrantFiled: October 1, 2009Date of Patent: February 5, 2013Assignee: Carl Zeiss Microimaging GmbHInventors: Cynthia B. Perz, Jose De La Torre-Bueno, Robert T. Ellis, Gina Marie McLaren, Mary Jean Smith
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Patent number: 8116543Abstract: The present disclosure includes systems and techniques relating to intelligently directed segmentation analysis for automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region including a biological specimen, partitioning the obtained image into zelles, determining one or more parameters of the zelles, performing a cluster analysis on the one or more parameters of the zelles, differentiating tissue of greater interest from tissue of lesser interest in the obtained image based on the cluster analysis and based on a test being performed for the biological specimen, and storing more information for the tissue of greater interest than information for the tissue of lesser interest. The cluster analysis can be a multivariate statistical cluster analysis, and the zelles can be test-dependent zelles (e.g., having dimensions defined according to the test being performed for the biological specimen).Type: GrantFiled: July 13, 2009Date of Patent: February 14, 2012Assignee: Carl Zeiss MicroImaging GmbHInventors: Cynthia B. Perz, Robert T. Ellis, Jose De La Torre-Bueno
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Patent number: 8000511Abstract: The present disclosure includes systems and techniques relating to focusing in automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region, analyzing the image to find an area in the image representing a sample, determining a nature of the sample at a selected focus point location in the area in the image, selecting an automated focusing process for use at the selected focus point location based on the determined nature of the sample at the selected focus point location, and focusing the selected automated focusing process. The selecting can include selecting different automated focusing processes for different focus point locations based on different tissue characteristics at the locations.Type: GrantFiled: April 20, 2010Date of Patent: August 16, 2011Assignee: Carl Zeiss Microimaging GmbHInventor: Cynthia B. Perz
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Patent number: 7873193Abstract: Automated projection of serial section images in microscopic imaging systems. A computer-controlled microscope that is connected electrically to a controller that has a display device. A batch of serial section slides includes a series of serial section slides, each of which has a microscope slide, a sample, and an interesting area. If one of the images is misregistered, then the images may be transformed.Type: GrantFiled: June 21, 2006Date of Patent: January 18, 2011Assignee: Carl Zeiss MicroImaging GmbHInventors: Jose De La Torre-Bueno, Cynthia B. Perz, Robert T. Ellis
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Publication number: 20100265323Abstract: The present disclosure includes systems and techniques relating to focusing in automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region, analyzing the image to find an area in the image representing a sample, determining a nature of the sample at a selected focus point location in the area in the image, selecting an automated focusing process for use at the selected focus point location based on the determined nature of the sample at the selected focus point location, and focusing the selected automated focusing process. The selecting can include selecting different automated focusing processes for different focus point locations based on different tissue characteristics at the locations.Type: ApplicationFiled: April 20, 2010Publication date: October 21, 2010Inventor: Cynthia B. Perz
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Publication number: 20100141682Abstract: Systems and techniques to acquire image data. In general, in one implementation, the technique includes: acquiring image data for a plurality of areas of a scan region. The technique may further include processing the image data to determine whether an area includes one or more desired features. The technique may further include designating an area as “interesting” if it includes a desired feature, and designating an area as non-interesting if it does not include the desired feature. The areas may be sub-divided one or more times, and subdivisions may be analyzed to determine if they include a desired feature.Type: ApplicationFiled: October 1, 2009Publication date: June 10, 2010Inventors: Cynthia B. Perz, Jose De La Torre-Bueno, Robert T. Ellis, Gina Marie McLaren, Mary Jean Smith
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Publication number: 20100040266Abstract: The present disclosure includes systems and techniques relating to intelligently directed segmentation analysis for automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region including a biological specimen, partitioning the obtained image into zelles, determining one or more parameters of the zelles, performing a cluster analysis on the one or more parameters of the zelles, differentiating tissue of greater interest from tissue of lesser interest in the obtained image based on the cluster analysis and based on a test being performed for the biological specimen, and storing more information for the tissue of greater interest than information for the tissue of lesser interest. The cluster analysis can be a multivariate statistical cluster analysis, and the zelles can be test-dependent zelles (e.g., having dimensions defined according to the test being performed for the biological specimen).Type: ApplicationFiled: July 13, 2009Publication date: February 18, 2010Inventors: Cynthia B. Perz, Robert T. Ellis, Jose De La Torre-Bueno
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Patent number: 7653260Abstract: Disclosed is a system for and a method of registering images captured by a computer-controlled microscope. The imaging system of the present invention includes a computer-controlled microscope electrically connected to a controller having a display device. The microscope further includes a barcode reader, a camera, a serial interface, one or more sensors, one or more motors, a light source, a turret, and a data interface. The method of image registration includes the steps of defining areas of interest on a microscope slide, creating a database of microscopic image locations, commanding a microscope to each location, capturing and storing an image, calculating correlation with neighbors, registering correlation scores and offsets, determining an anchor, and attaching neighbors using correlation scores and offsets.Type: GrantFiled: June 17, 2004Date of Patent: January 26, 2010Assignee: Carl Zeis MicroImaging GmbHInventors: Cynthia B. Perz, Jose De La Torre-Bueno
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Patent number: 7627153Abstract: Systems and techniques for reducing repositioning inaccuracies in imaging systems. Initial image data and positional information is received and cross-correlated with additional image data and positional information. An offset may be determined based on the cross-correlation.Type: GrantFiled: August 4, 2005Date of Patent: December 1, 2009Assignee: Carl Zeiss MicroImaging GmbHInventors: Cynthia B. Perz, Robert T. Ellis
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Publication number: 20040202357Abstract: Systems and techniques to acquire image data. In general, in one implementation, the technique includes: acquiring image data for a plurality of areas of a scan region. The technique may further include processing the image data to determine whether an area includes one or more desired features. The technique may further include designating an area as “interesting” if it includes a desired feature, and designating an area as non-interesting if it does not include the desired feature. The areas may be sub-divided one or more times, and subdivisions may be analyzed to determine if they include a desired feature.Type: ApplicationFiled: April 11, 2003Publication date: October 14, 2004Inventors: Cynthia B. Perz, Jose De La Torre-Bueno, Robert T. Ellis, Gina Marie McLaren, Mary Jean Smith