Patents by Inventor Cynthia Clague

Cynthia Clague has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230149160
    Abstract: A transcatheter prosthesis includes a stent, a prosthetic valve component, and an anti-paravalvular leakage component. The anti-paravalvular leakage component is coupled to the stent and includes an inner skirt, an outer wrap, a cavity, an opening, and a one-way valve. The inner skirt is disposed on an inner surface of the stent and has an inflow end and a downstream end. The outer wrap is disposed around an outer surface of the stent and has an inflow end coupled to the inflow end of the inner skirt and a downstream end. The cavity is formed between an outer surface of the inner skirt and an inner surface of the outer wrap. An opening is disposed between the inner skirt and the outer wrap. The one-way valve includes a flap at the opening configured to open to allow blood flow into the cavity but prevent blood flow out of the cavity.
    Type: Application
    Filed: January 13, 2023
    Publication date: May 18, 2023
    Inventors: Cynthia Clague, Ana Menk, Timothy Petersen, Paul Rothstein, Stephen Roller
  • Patent number: 11583397
    Abstract: A transcatheter prosthesis includes a stent, a prosthetic valve component, and an anti-paravalvular leakage component. The anti-paravalvular leakage component is coupled to the stent and includes an inner skirt, an outer wrap, a cavity, an opening, and a one-way valve. The inner skirt is disposed on an inner surface of the stent and has an inflow end and a downstream end. The outer wrap is disposed around an outer surface of the stent and has an inflow end coupled to the inflow end of the inner skirt and a downstream end. The cavity is formed between an outer surface of the inner skirt and an inner surface of the outer wrap. An opening is disposed between the inner skirt and the outer wrap. The one-way valve includes a flap at the opening configured to open to allow blood flow into the cavity but prevent blood flow out of the cavity.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: February 21, 2023
    Assignee: Medtronic, Inc.
    Inventors: Cynthia Clague, Ana Menk, Timothy Petersen, Paul Rothstein, Stephen Roller
  • Publication number: 20220304805
    Abstract: A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.
    Type: Application
    Filed: June 16, 2022
    Publication date: September 29, 2022
    Inventors: Cynthia Clague, Scott Mosher, Marian Creaven, Declan Costello, Gavin Kenny, Michael Krivoruchko, Adam Shipley, Mark Torianni, Kshitija Garde, Eric Richardson
  • Publication number: 20210085453
    Abstract: A transcatheter prosthesis includes a stent, a prosthetic valve component, and an anti-paravalvular leakage component. The anti-paravalvular leakage component is coupled to the stent and includes an inner skirt, an outer wrap, a cavity, an opening, and a one-way valve. The inner skirt is disposed on an inner surface of the stent and has an inflow end and a downstream end. The outer wrap is disposed around an outer surface of the stent and has an inflow end coupled to the inflow end of the inner skirt and a downstream end. The cavity is formed between an outer surface of the inner skirt and an inner surface of the outer wrap. An opening is disposed between the inner skirt and the outer wrap. The one-way valve includes a flap at the opening configured to open to allow blood flow into the cavity but prevent blood flow out of the cavity.
    Type: Application
    Filed: September 24, 2019
    Publication date: March 25, 2021
    Inventors: Cynthia Clague, Ana Menk, Tim Petersen, Paul Rothstein, Stephen Roller
  • Publication number: 20210085455
    Abstract: Stented prosthetic heart valves comprising a stent frame having a compressed arrangement for delivery within a patient's vasculature and an expanded arrangement for deployment within a native heart valve. The stented prosthetic heart valves including a paravalvular leakage prevention or mitigation wrap that encircles a stent frame and is formed of a flexible material having a variable diameter defined by a greatest distance between the wrap and the stent frame. The wrap further includes a first end coupled to the stent frame and an opposing second end that is not coupled to the stent frame, wherein the wrap can selectively enlarge its diameter in situ via movement of the second end. Devices for and methods of selectively deploying the wrap are also disclosed.
    Type: Application
    Filed: December 9, 2020
    Publication date: March 25, 2021
    Applicant: Medtronic Vascular, Inc.
    Inventors: Michael Bateman, Cynthia Clague, Jeffrey Sandstrom, Joel Racchini, James R. Keogh
  • Publication number: 20210045875
    Abstract: Systems and methods for modifying a heart valve annulus in a minimally invasive surgical procedure. A helical anchor is provided, having a memory set to a coiled shape or state. The helical anchor is further configured to self-revert from a substantially straight state to the coiled state. The helical anchor is loaded within a needle that constrains the helical anchor to the substantially straight state. The needle is delivered to the valve annulus and inserted into tissue of the annulus. The helical anchor is then deployed from the needle (e.g., the needle is retracted from over the helical anchor). Once deployed, the helical anchor self-transitions toward the coiled shape, cinching engaged tissue of the valve annulus.
    Type: Application
    Filed: November 2, 2020
    Publication date: February 18, 2021
    Inventors: Jason QUILL, Cynthia Clague, Michael Green, Alexander J. Hill, Ana Menk, Paul Rothstein, Georg Bortlein
  • Patent number: 10888420
    Abstract: Stented prosthetic heart valves comprising a stent frame having a compressed arrangement for delivery within a patient's vasculature and an expanded arrangement for deployment within a native heart valve. The stented prosthetic heart valves including a paravalvular leakage prevention or mitigation wrap that encircles a stent frame and is formed of a flexible material having a variable diameter defined by a greatest distance between the wrap and the stent frame. The wrap further includes a first end coupled to the stent frame and an opposing second end that is not coupled to the stent frame, wherein the wrap can selectively enlarge its diameter in situ via movement of the second end. Devices for and methods of selectively deploying the wrap are also disclosed.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: January 12, 2021
    Assignee: Medtronic Vascular, Inc.
    Inventors: Michael Bateman, Cynthia Clague, Jeffrey Sandstrom, Joel Racchini, James R. Keogh
  • Patent number: 10849749
    Abstract: Systems and methods for modifying a heart valve annulus in a minimally invasive surgical procedure. A helical anchor is provided, having a memory set to a coiled shape or state. The helical anchor is further configured to self-revert from a substantially straight state to the coiled state. The helical anchor is loaded within a needle that constrains the helical anchor to the substantially straight state. The needle is delivered to the valve annulus and inserted into tissue of the annulus. The helical anchor is then deployed from the needle (e.g., the needle is retracted from over the helical anchor). Once deployed, the helical anchor self-transitions toward the coiled shape, cinching engaged tissue of the valve annulus.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: December 1, 2020
    Assignee: MEDTRONIC, INC.
    Inventors: Jason Quill, Cynthia Clague, Michael Green, Alexander J. Hill, Ana Menk, Paul Rothstein, Georg Bortlein
  • Patent number: 10548723
    Abstract: A stented valve having at least one leaflet made of pericardium or other material having a relatively thin profile at the annulus. The leaflets are attached via chords to a stent frame, where the chords are positioned to mimic the native valve anatomy and functionality. In particular, the valves of one exemplary embodiment of the invention are sized to replace a mitral valve and therefore the chords are arranged to prevent prolapse of the leaflets into the atrium. The stented valve has a relatively short height at its annulus due to the positioning of the chords. In addition, the stented valve is capable of being crimped to a small enough size that it can be delivered to the implantation site via transcatheter delivery systems and methods.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: February 4, 2020
    Assignee: Medtronic, Inc.
    Inventors: Alexander J. Hill, Cynthia Clague, Carol E. Eberhardt, Ana Menk, Mark J. Capps, Billie Millwee, Janice Lynn Shay, Debra Taitague, Joseph C. Morrow, Jerald Redmond
  • Patent number: 10322000
    Abstract: Aspects of the disclosure include sizing catheters and methods for determining the size and other physical parameters of an internal orifice or lumen. Embodiments include a sizing catheter assembly having a handle assembly and a catheter assembly including at least one catheter extending from the handle assembly. The catheter assembly also includes at least two sizers, which can be adjustably spaced from each other. Each of the sizers are configured to conform to respective portions of a lumen of a patient's anatomy. The sizing catheter is configured such that the sizers are configured to specify or determine first and second dimensions of the lumen and also distance between the sizers. The sizers can include valve leaflets or the sizing catheter can include a temporary valve. Additional aspects include software/methods of assessing and determining an appropriate implantable device that can include assessing the biomechanical interaction between the device and the anatomy.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: June 18, 2019
    Assignee: Medtronic Vascular, Inc.
    Inventors: Geoffrey Orth, Mostafa Toloui, Kshitija Garde, Michael Krivoruchko, Brian McHenry, Wei Wang, Tracey Tien, Sarah Ahlberg, Cynthia Clague
  • Patent number: 10179045
    Abstract: Systems and methods of delivering and deploying a stented prosthetic heart valve having a wrap that is automatically deployed to prevent or mitigate paravalvular leakage. In various embodiments, during transcatheter delivery of the stented prosthetic heart valve, the wrap is extends beyond a stent frame of the stented prosthetic heart valve so that the profile of the stented prosthetic heart valve is not increased during delivery. The disclosed embodiments are arranged and configured so that upon expansion of a stent frame of the stented prosthetic heart valve, a plurality of elongated members automatically pull the wrap distally into a deployed arrangement.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: January 15, 2019
    Assignee: Medtronic Vascular, Inc.
    Inventors: Joel Racchini, Kshitija Garde, Paul Rothstein, Jeffrey Sandstrom, Cynthia Clague
  • Publication number: 20180318080
    Abstract: Systems and methods for modifying a heart valve annulus in a minimally invasive surgical procedure. A helical anchor is provided, having a memory set to a coiled shape or state. The helical anchor is further configured to self-revert from a substantially straight state to the coiled state. The helical anchor is loaded within a needle that constrains the helical anchor to the substantially straight state. The needle is delivered to the valve annulus and inserted into tissue of the annulus. The helical anchor is then deployed from the needle (e.g., the needle is retracted from over the helical anchor). Once deployed, the helical anchor self-transitions toward the coiled shape, cinching engaged tissue of the valve annulus.
    Type: Application
    Filed: July 12, 2018
    Publication date: November 8, 2018
    Inventors: Jason Quill, Cynthia Clague, Michael Green, Alexander J. Hill, Ana Menk, Paul Rothstein, Georg Bortlein
  • Patent number: 10105225
    Abstract: Systems and methods for approximating tissue segments, such as mitral valve leaflets, on a minimally invasive basis. The system includes first and second approximation devices each including a magnetic component and an attachment mechanism. Each device is connected to a target tissue segment by the corresponding attachment mechanism. Upon deployment at a target site, the tissue approximation devices are magnetically attracted to one another, approximating the tissue segments and maintaining the tissue segments in the approximated state.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: October 23, 2018
    Assignee: Medtronic, Inc.
    Inventors: Cynthia Clague, James Keogh, Ana Menk, Paul Rothstein
  • Publication number: 20180289488
    Abstract: Aspects of the disclosure include sizing catheters and methods for determining the size and other physical parameters of an internal orifice or lumen. Embodiments include a sizing catheter assembly having a handle assembly and a catheter assembly including at least one catheter extending from the handle assembly. The catheter assembly also includes at least two sizers, which can be adjustably spaced from each other. Each of the sizers are configured to conform to respective portions of a lumen of a patient's anatomy. The sizing catheter is configured such that the sizers are configured to specify or determine first and second dimensions of the lumen and also distance between the sizers. The sizers can include valve leaflets or the sizing catheter can include a temporary valve. Additional aspects include software/methods of assessing and determining an appropriate implantable device that can include assessing the biomechanical interaction between the device and the anatomy.
    Type: Application
    Filed: April 5, 2018
    Publication date: October 11, 2018
    Inventors: Geoffrey Orth, Mostafa Toloui, Kshitija Garde, Michael Krivoruchko, Brian McHenry, Wei Wang, Tracey Tien, Sarah Ahlberg, Cynthia Clague
  • Publication number: 20180228603
    Abstract: Systems and methods of delivering and deploying a stented prosthetic heart valve having a wrap that is automatically deployed to prevent or mitigate paravalvular leakage. In various embodiments, during transcatheter delivery of the stented prosthetic heart valve, the wrap is extends beyond a stent frame of the stented prosthetic heart valve so that the profile of the stented prosthetic heart valve is not increased during delivery. The disclosed embodiments are arranged and configured so that upon expansion of a stent frame of the stented prosthetic heart valve, a plurality of elongated members automatically pull the wrap distally into a deployed arrangement.
    Type: Application
    Filed: April 18, 2018
    Publication date: August 16, 2018
    Inventors: Joel Racchini, Kshitija Garde, Paul Rothstein, Jeffrey Sandstrom, Cynthia Clague
  • Patent number: 10028832
    Abstract: Systems and methods for modifying a heart valve annulus in a minimally invasive surgical procedure. A helical anchor is provided, having a memory set to a coiled shape or state. The helical anchor is further configured to self-revert from a substantially straight state to the coiled state. The helical anchor is loaded within a needle that constrains the helical anchor to the substantially straight state. The needle is delivered to the valve annulus and inserted into tissue of the annulus. The helical anchor is then deployed from the needle (e.g., the needle is retracted from over the helical anchor). Once deployed, the helical anchor self-transitions toward the coiled shape, cinching engaged tissue of the valve annulus.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: July 24, 2018
    Assignee: MEDTRONIC, INC.
    Inventors: Jason Quill, Cynthia Clague, Michael Green, Alexander J. Hill, Ana Menk, Paul Rothstein, Georg Bortlein
  • Patent number: 9974649
    Abstract: Systems and methods of delivering and deploying a stented prosthetic heart valve having a wrap that is automatically deployed to prevent or mitigate paravalvular leakage. In various embodiments, during transcatheter delivery of the stented prosthetic heart valve, the wrap is extends beyond a stent frame of the stented prosthetic heart valve so that the profile of the stented prosthetic heart valve is not increased during delivery. The disclosed embodiments are arranged and configured so that upon expansion of a stent frame of the stented prosthetic heart valve, a plurality of elongated members automatically pull the wrap distally into a deployed arrangement.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: May 22, 2018
    Assignee: Medtronic Vascular, Inc.
    Inventors: Joel Racchini, Kshitija Garde, Paul Rothstein, Jeffrey Sandstrom, Cynthia Clague
  • Publication number: 20180055632
    Abstract: A stented valve having at least one leaflet made of pericardium or other material having a relatively thin profile at the annulus. The leaflets are attached via chords to a stent frame, where the chords are positioned to mimic the native valve anatomy and functionality. In particular, the valves of one exemplary embodiment of the invention are sized to replace a mitral valve and therefore the chords are arranged to prevent prolapse of the leaflets into the atrium. The stented valve has a relatively short height at its annulus due to the positioning of the chords. In addition, the stented valve is capable of being crimped to a small enough size that it can be delivered to the implantation site via transcatheter delivery systems and methods.
    Type: Application
    Filed: October 25, 2017
    Publication date: March 1, 2018
    Inventors: Alexander J. Hill, Cynthia Clague, Carol E. Eberhardt, Ana Menk, Mark J. Capps, Billie Millwee, Janice Lynn Shay, Debra Taitague, Jospeh C. Morrow, Jerald Redmond
  • Patent number: 9827090
    Abstract: A stented valve having at least one leaflet made of pericardium or other material having a relatively thin profile at the annulus. The leaflets are attached via chords to a stent frame, where the chords are positioned to mimic the native valve anatomy and functionality. In particular, the valves of one exemplary embodiment of the invention are sized to replace a mitral valve and therefore the chords are arranged to prevent prolapse of the leaflets into the atrium. The stented valve has a relatively short height at its annulus due to the positioning of the chords. In addition, the stented valve is capable of being crimped to a small enough size that it can be delivered to the implantation site via transcatheter delivery systems and methods.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: November 28, 2017
    Assignee: Medtronic, Inc.
    Inventors: Alexander J. Hill, Cynthia Clague, Carol E. Eberhardt, Ana Menk, Mark J. Capps, Billie Millwee, Janice Lynn Shay, Debra Taitague, Joseph C. Morrow, Jerald Redmond
  • Publication number: 20170273784
    Abstract: Systems and methods of delivering and deploying a stented prosthetic heart valve having a wrap that is automatically deployed to prevent or mitigate paravalvular leakage. In various embodiments, during transcatheter delivery of the stented prosthetic heart valve, the wrap is extends beyond a stent frame of the stented prosthetic heart valve so that the profile of the stented prosthetic heart valve is not increased during delivery. The disclosed embodiments are arranged and configured so that upon expansion of a stent frame of the stented prosthetic heart valve, a plurality of elongated members automatically pull the wrap distally into a deployed arrangement.
    Type: Application
    Filed: March 24, 2016
    Publication date: September 28, 2017
    Inventors: Joel Racchini, Kshitija Garde, Paul Rothstein, Jeffrey Sandstrom, Cynthia Clague