Patents by Inventor Cynthia Loeffler

Cynthia Loeffler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipsome containing IL-2
    Patent number: 5773006
    Abstract: The present invention provides a liposome comprising an effective immunoadjuvant amount of a lymphokine such as IL-2. Also provided is an effective antineoplastic amount of IL-2 liposomes in combination with adoptively transferred cells stimulated with anti-CD3 monoclonal antibody plus IL-2.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: June 30, 1998
    Assignee: Regents of the University of Minnesota
    Inventors: Peter M. Anderson, Arnold S. Leonard, Augusto C. Ochoa, Cynthia Loeffler
  • Liposome immunoadjuvants containing IL-2
    Patent number: 5650152
    Abstract: The present invention provides a liposome comprising an effective immunoadjuvant amount of a lymphokine such as IL-2. Also provided is an effective antineoplastic amount of IL-2 liposomes in combination with adoptively transferred cells stimulated with anti-CD3 monoclonal antibody plus IL-2.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: July 22, 1997
    Assignee: Regents of the University of Minnesota
    Inventors: Peter M. Anderson, Arnold S. Leonard, Augusto C. Ochoa, Cynthia Loeffler
  • Liposome immunoadjuvants containing IL-2
    Patent number: 5409698
    Abstract: The present invention provides a liposome comprising an effective immunoadjuvant amount of a lymphokine such as IL-2. Also provided is an effective antineoplastic amount of IL-2 liposomes in combination with adoptively transferred cells stimulated with anti-CD3 monoclonal antibody plus IL-2.
    Type: Grant
    Filed: October 28, 1992
    Date of Patent: April 25, 1995
    Assignee: The Regents of The University of Minnesota
    Inventors: Peter M. Anderson, Arnold S. Leonard, Augusto C. Ochoa, Cynthia Loeffler
  • Short-term anti-CD3 stimulation of lymphocytes to increase their in vivo acitivity
    Patent number: 5316763
    Abstract: The present invention is directed to a method of increasing the in vivo immune response of lymphocytes by stimulating the lymphocytes in vitro in the presence of an anti-CD3 monoclonal antibody for less than about 24 hours to form stimulated lymphocytes; infusing the stimulated lymphocytes into a tumor-bearing mammal; and administering IL-2 to the mammal. As a result of this method, the anti-CD3 stimulated lymphocytes display enhanced immunotherapeutic, e.g., cytotoxicity or lymphokine production, in vivo as represented by a decrease in the number of tumors by at least about 20%.
    Type: Grant
    Filed: July 10, 1992
    Date of Patent: May 31, 1994
    Assignees: The United States of America as represented by the Department of Health and Human Services, Regents of the University of Minnesota
    Inventors: Augusto C. Ochoa, Cynthia Loeffler, Walter Urba, Dan L. Longo