Patents by Inventor Cynthia Nau Cornelissen

Cynthia Nau Cornelissen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transferrin-binding proteins from
    Patent number: 7582730
    Abstract: Iron-regulated, outer membrane proteins found in Neisseria gonorrhoeae and Neisseria meningitidis are important in transferrin receptor function. The proteins, which are isolatable by means of a transferrin affinity column, bind specifically to antisera raised against an iron-regulated outer membrane protein having a molecular weight of approximately 100 kD found in Neisseria gonorrhoeae.
    Type: Grant
    Filed: August 30, 2004
    Date of Patent: September 1, 2009
    Assignee: University of North Carolina at Chapel Hill
    Inventors: P. Frederick Sparling, Cynthia Nau Cornelissen
  • Chimeric Tbp-toxin proteins as mucosal adjuvants for vaccination against neisseriae
    Publication number: 20080206260
    Abstract: Chimeric fusion proteins comprising Neisseria transferrin binding proteins (Tbps) from, for example, N. gonorrhoeae and/or N. meningitidis are provided. The fusion proteins elicit an antibody response in the mucosa of the urogenital and/or oropharynx tract, as well as in the serum. The resulting serum antibodies are cross-bactericidal against heterologous bacterial strains. The chimeric proteins also comprise a mucosal adjuvant such as a toxin subunit, e.g. the B subunit of cholera toxin or of Escherichia coli heat labile toxin II. Methods of inhibiting the growth of Neisseria species on mucosal surfaces of a mammal by either administering the fusion proteins of the invention, or antibodies directed to the fusion proteins of the invention, to the mammal.
    Type: Application
    Filed: December 21, 2007
    Publication date: August 28, 2008
    Inventors: Cynthia Nau Cornelissen, Gregory Price, Michael Russell, Terry Connell
  • TRANSFERRIN-BINDING PROTEINS FROM N.GONORRHOEAE AND N. MENINGITIDIS
    Publication number: 20020025318
    Abstract: Iron-regulated, outer membrane proteins found in Neisseria gonorrhoeae and Neisseria meningitidis are important in transferrin receptor function. The proteins, which are isolatable by means of a transferrin affinity column, bind specifically to antisera raised against an iron-regulated outer membrane protein having a molecular weight of approximately 100 kD found in Neisseria gonorrhoeae.
    Type: Application
    Filed: June 14, 1999
    Publication date: February 28, 2002
    Applicant: University of North Carolina
    Inventors: P. FREDERICK SPARLING, CYNTHIA NAU CORNELISSEN
  • Isolated nucleic acid molecules encoding transferrin binding proteins from Neisseria gonorrhoeae and Neisseria meningitidis
    Patent number: 5912336
    Abstract: Iron-regulated, outer membrane proteins found in Neisseria gonorrhoeae and Neisseria meningitidis are important in transferrin receptor function. The proteins, which are isolatable by means of a transferrin affinity column, bind specifically to antisera raised against an iron-regulated outer membrane protein having a molecular weight of approximately 100 kD found in Neisseria gonorrhoeae.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: June 15, 1999
    Assignee: University of North Carolina at Chapel Hill
    Inventors: P. Frederick Sparling, Cynthia Nau Cornelissen