Abstract: Certain aspects of the present disclosure provide techniques for generating a replacement sentence with the same or similar meaning but a different sentiment than an input sentence. The method generally includes receiving a request for a replacement sentence and iteratively determining a next word of the replacement sentence word-by-word based on an input sentence. Iteratively determining the next word generally includes evaluating a set of words of the input sentence using a language model configured to output candidate sentences and evaluating the candidate sentences using a sentiment model configured to output sentiment scores for the candidates sentences. Iteratively determining the next word further includes calculating convex combinations for the candidate sentences and selecting an ending word of one of the candidate sentences as the next word of the replacement sentence. The method further includes transmitting the replacement sentence in response to the request for the replacement sentence.

Abstract: The present disclosure relates to methods and systems for quantifying the vascular pattern using ocular imaging that shows vessel profiles for the detection, prevention, and treatment of diabetic retinopathy and other related ocular vascular diseases.

Abstract: An improved methodology for the treatment of corneal abnormalities involving the application of a crosslinking solution, such as riboflavin, to the surface of the cornea followed by exposure to UV light such that the rigidity of the cornea is increased and stabilized, the method improved by providing a transparent contact lens that is selectively etched to create areas on the lens that either preclude or reduce penetration of UV light, thereby eliminating or reducing crosslinking for areas of the cornea that do not require stabilization while allowing penetration of UV light to areas of the cornea that do require stabilization.

Abstract: The present invention discloses a corneal refractive procedure providing a customized transition zone. The customized transition zone provided according to the methods and systems of the present invention exhibits continuous curvature between an ablated optical zone and a non-ablated zone to address curvature discontinuity at the edge of the optical zone, thereby minimizing the biomechanical response and its postoperative effects on vision.

Abstract: In various embodiments, provided are multi-functional biodegradable particles for selectable targeting, imaging, and delivery of therapeutic agents. Also provided are methods of using the provided particles for treatment of ocular disorders, such as for the treatment of age-related macular degeneration. The provided particles and methods provide a clinician with options for control over, and monitoring of, the delivery of therapeutic agents.

Abstract: An advanced rasterstereography-based corneo-scleral topography (RCT) device includes an LED-based grid projection/illumination assembly, a grid image viewing assembly, and an optionally integratable front view camera assembly. The assemblies each include telephoto optical systems that provide a compact structure, an increased depth of field, and an increased field of view that allow sufficient acquisition of data in a single acquired image to provide the desired corneo-scleral topography analysis. The device utilizes a novel image processing algorithm. The device and method provide the capability to map a feature from a raw grid image onto a topography map of the corneo-scleral region, and to simultaneously display the images if selected by the user. The hardware, software, mechanical, electrical, and optical design considerations and integration provide advantages and benefits over prior RCT-type, Placido-based, and other conventional corneal topographers.

Abstract: A method of improving vision by reshaping the cornea to correct for abnormal surface curvature by measuring the surface topography of the cornea, providing a rigid contact lens to reshape the cornea into a more desirable configuration, wearing the contact lens for sufficient time to achieve the reshaping, removing the contact lens, applying an alcohol solution to the epithelial layer, applying a riboflavin solution to the cornea, and subjecting the cornea to UV light for sufficient time to induce cross-linking of collagen fibers within the cornea, whereby the cornea is stabilized in the reshaped desirable configuration.

Abstract: An advanced rasterstereography-based corneo-scleral topography (RCT) device includes an LED-based grid projection assembly, a grid image viewing assembly, and an optionally integratable front view camera assembly. The assemblies each include telephoto optical systems that provide a compact structure, an increased depth of field, and an increased field of view that allow sufficient acquisition of data in a single acquired image to provide the desired corneo-scleral topography analysis. The device utilizes a novel image processing algorithm. The device and method provide the capability to map a feature from a raw grid image onto a topography map of the corneo-scleral region, and to simultaneously display the images if selected by the user. The hardware, software, mechanical, electrical, and optical design considerations and integration provide advantages and benefits over prior RCT-type, Placido-based, and other conventional corneal topographers.

Abstract: The purpose of this invention is to provide a corneal topography system for use by eye car professionals to diagnose and correct vision defects; particularly, to an advanced corneal topography system which accurately assess the shape of the human cornea utilizing a projected grid and current digital camera technology.

Abstract: A method and apparatus related to enhancing corneal accommodation to address the effect of presbyopia. Corneal/scleral topology measurements in accommodating and non-accommodating states are indicative of a presbyopic subject's nominal corneal accommodative power. A desired accommodative power intended to improve on the effect of presbyopia can be determined, suggesting a selective biomechanical intervention in the corneal structure outside of the optical zone to create flexure regions. These flexure regions would allow enhanced corneal accommodation upon presentation of an accommodating stimulus. Intervention could be in the form of, for example, corneal surface ablation, intrastromal ablation, conductive keratoplasty (CK), laser thermal keratoplasty (LTK), and corneal and/or scleral implants. An improved topology measuring apparatus having an improved field of view and other attributes is disclosed.

Abstract: Methods, computer programs, and systems for processing a request through a web service on a server are provided. The method includes receiving a batch request from a client. The batch request includes a plurality of sub-requests that each specifies an operation to be performed by the web service. The method further includes processing the batch request through the web service including performing the operation specified by each of the plurality of sub-requests and generating a corresponding plurality of sub-replies. Each sub-reply contains result data of the processing of a corresponding sub-request. The method further includes constructing a batch reply including the plurality of sub-replies, and returning the batch reply to the client.

Abstract: The present invention discloses a corneal refractive procedure providing a customized transition zone. The customized transition zone provided according to the methods and systems of the present invention exhibits continuous curvature between an ablated optical zone and a non-ablated zone to address curvature discontinuity at the edge of the optical zone, thereby minimizing the biomechanical response and its postoperative effects on vision.

Abstract: Biomechanical responses of the eye are used to improve photorefractive procedures. LASIK or PRK treatments, for example, can be improved by taking pre-operative measurement and predicting the corneas's biodynamic response to the ablative treatment. Predicitve use is mad of the biodynamic response of the cornea due to laser or mechanical keratectomy, that is, creating a corneal flap characterisitc of LASIK. Comparison of pre-flap and post-flap, (pre-ablation) data of the cornea such as corneal thickness, flap thickness, corneal topography and wavefront, for example, can provide predictive information applicable to modifying an ablation alorithm before the laser is engaged, either for a current operation or the development of a model.