Patents by Inventor Cynthia Seidel-Dugan

Cynthia Seidel-Dugan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF
    Publication number: 20120208844
    Abstract: The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
    Type: Application
    Filed: October 5, 2010
    Publication date: August 16, 2012
    Inventors: Stephane L. Bogen, Yao Ma, Yaolin Wang, Brian Robert Lahue, Latha G. Nair, Manami Shizuka, Matthew Ernst Voss, Margarita Kirova-Snover, Weidong Pan, Yuan Tian, Bheemashankar A. Kulkarni, Craig R. Gibeau, Yuan Liu, Giovanna Scapin, Diane Rindgen, Ronald J. Doll, Timothy J. Guzi, Danny J. Hicklin, Amin Nomeir, Cynthia Seidel-Dugan, Gerald W. Shipps, JR., Malcolm MacCoss
  • METHODS OF TREATMENT
    Publication number: 20110262525
    Abstract: This invention relates to compositions and methods useful for treating various cancers. Therapeutic combinations and methods of use thereof are also covered in the present application.
    Type: Application
    Filed: December 11, 2007
    Publication date: October 27, 2011
    Applicant: SCHERING CORPORATION
    Inventors: Yan Wang, Chen Zong, Cynthia Seidel-Dugan, Yaolin Wang, Siu-Long Yao, Brian Der-Hua Lu, Mohamad H. Ladha
  • Sequential Administration of Chemotherapeutic Agents for Treatment of Cancer
    Publication number: 20110129456
    Abstract: The present invention relates to the sequential administration of a cytotoxic agent followed by an IGF1R antagonist (e.g., an antibody) for the treatment of hyperproliferative disorders including cancer.
    Type: Application
    Filed: May 4, 2009
    Publication date: June 2, 2011
    Inventors: Yaolin Wang, Yan Wang, Brian Der-Hua Lu, Ming Liu, Cynthia Seidel-Dugan, Siu-Long Yao
  • METHODS FOR TREATING OR PREVENTING COLORECTAL CANCER
    Publication number: 20110104256
    Abstract: The present invention provides, for example, methods for treating or preventing colorectal cancer with an anti-IGF1R antibody in association with sunitinib or a combination of leucovorin and 5-fluorouracil.
    Type: Application
    Filed: March 23, 2009
    Publication date: May 5, 2011
    Inventors: Yaolin Wang, Yan Wang, Ming Liu, Walter Robert Bishop, Cynthia Seidel-Dugan
  • BIOMARKERS FOR SENSITIVITY TO ANTI-IGF1R THERAPY
    Publication number: 20110091524
    Abstract: The present invention provides, for example, methods for conveniently determining if a cancerous condition in a subject will be responsive to an IGF1R inhibitor. The invention includes patient selection methods and methods of treatment.
    Type: Application
    Filed: December 17, 2008
    Publication date: April 21, 2011
    Inventors: Yan Wang, Yaolin Wang, Diene Levitan, Cynthia Seidel-Dugan, Ming Liu, Wei Ding
  • Minrs as modifiers of insulin receptor signaling and methods of use
    Publication number: 20060088829
    Abstract: Human MINR genes are identified as modulators of INR signaling and thus are therapeutic targets for disorders associated with defective INR signaling. Methods for identifying modulators of MINR, comprising screening for agents that modulate the activity of MINR are provided.
    Type: Application
    Filed: February 5, 2003
    Publication date: April 27, 2006
    Inventors: Arthur Brace, Agnes Eliares, Kimberly Ferguson, Cynthia Seidel-Dugan, Felipa Mapa, Donald Ruhrmund, Jianfeng Wu
  • Srebp pathway modulation through targeting hisrs
    Publication number: 20040101879
    Abstract: Human HisRS genes are identified as modulators of the SREPB pathway and thus are therapeutic for disorders associated with the SREBP pathway. Methods for identifying modulators of HisRS, comprising screening for agents that modulate the activity of HisRS are provided.
    Type: Application
    Filed: November 4, 2003
    Publication date: May 27, 2004
    Inventors: Cynthia Seidel-Dugan, Lisa C. Kadyk, Felipa A. Mapa