Patents by Inventor Cynthia St. Hilaire

Cynthia St. Hilaire has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically modified mesenchymal stem cells for use in cardiovascular prosthetics
    Patent number: 11634716
    Abstract: A cardiovascular graft is provided, such as a prosthetic heart valve or blood vessel, that comprises mesenchymal stem cells (MSCs) and/or progeny thereof, modified to knock down or knockout expression of the telomerases reverse transcriptase gene (TERT), or otherwise reduce activity of TERT. Also provided are a method of making the cardiovascular graft, and a method of implanting the cardiovascular graft.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: April 25, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventor: Cynthia St. Hilaire
  • Genetically Modified Mesenchymal Stem Cells for Use in Cardiovascular Prosthetics
    Publication number: 20210403915
    Abstract: A cardiovascular graft is provided, such as a prosthetic heart valve or blood vessel, that comprises mesenchymal stem cells (MSCs) and/or progeny thereof, modified to knock down or knockout expression of the telomerases reverse transcriptase gene (TERT), or otherwise reduce activity of TERT. Also provided are a method of making the cardiovascular graft, and a method of implanting the cardiovascular graft.
    Type: Application
    Filed: October 15, 2018
    Publication date: December 30, 2021
    Inventor: Cynthia St. Hilaire
  • ADENOSINE RECEPTOR AGONISTS FOR THE TREATMENT AND PREVENTION OF VASCULAR OR JOINT CAPSULE CALCIFICATION DISORDERS
    Publication number: 20130109645
    Abstract: Disclosed are a method of treating or preventing a disorder in a mammal comprising administering to the mammal an adenosine receptor agonist or an adenosine receptor antagonist, either alone or in combination, in an amount effective to treat or prevent medial vascular or joint capsule calcification. Disclosed are methods of detecting or diagnosing a vascular or joint capsule calcification disorder, as well as a nucleic acid comprising a mutation in one or more exons of human NT5E selected from the group consisting of Exon 3, Exon 5, and Exon 9.
    Type: Application
    Filed: March 30, 2011
    Publication date: May 2, 2013
    Applicant: The united States of America,as represented by Secretary,Dept.,of Health and Human Services
    Inventors: William A. Gahl, Manfred Boehm, Cynthia St. Hilaire, Shira G. Ziegler, Thomas C. Markello