Patents by Inventor Cyril BEN HAÏM

Cyril BEN HAÏM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF A BRUTON'S TYROSINE KINASE INHIBITOR
    Publication number: 20240158400
    Abstract: Described herein is the synthesis of Bruton's tyrosine kinase (Btk) inhibitor 1-(R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) piperidin-1-yl)prop-2-en-1-one.
    Type: Application
    Filed: June 14, 2023
    Publication date: May 16, 2024
    Inventors: Cyril Ben Haim, Wei Chen, Erick Goldman, Andras Horvath, Philip Pye, Mark S. Smyth, Erik J. Verner
  • PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B][1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
    Publication number: 20230416252
    Abstract: The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).
    Type: Application
    Filed: October 11, 2021
    Publication date: December 28, 2023
    Inventors: Subha MUKHERJEE, William P. GALLAGHER, Christopher Robert JAMISON, Carolyn S. WEI, Sergei KOLOTUCHIN, Amarjit SINGH, Nicolas CUNIERE, Chris SFOUGGATAKIS, Adrian ORTIZ, Steven R. WISNIEWSKI, Bin ZHENG, Helen Y. LUO, Sébastien François Emmanuel LEMAIRE, Cyril BEN HAÏM, Kostiantyn CHERNICHENKO, Diego Fernando Domenico BROGGINI, Simon Albert WAGSCHAL, Duy Chi Trung CAO, Karl REUTER, Björn SCHMALZBAUER, Philipp KOSCHKER, Martin D. EASTGATE, Dimitri SKLIAR, Alexander ZHDANKO, Christos XIOURAS, Matthew Penfield MOWER, Ngoc Duc TRAN, Ramdane RAHMANI, Xavier Jean-Marie JUSSEAU, Kiran MATCHA, Luca Alessandro PEREGO
  • PROCESSES AND INTERMEDIATES FOR PREPARING A BTK INHIBITOR
    Publication number: 20230107573
    Abstract: Disclosed is a process for the preparation of certain intermediates, e.g. the following compound: which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.
    Type: Application
    Filed: April 13, 2022
    Publication date: April 6, 2023
    Inventors: Cyril Ben Haim, Thomas Joost Martti Michiels, Florian Damien Medina, Simon Albert Wagschal, Dominique Paul M. Depré
  • NOVEL SYNTHETIC OPTIONS TOWARDS THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B][1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE
    Publication number: 20220144836
    Abstract: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.
    Type: Application
    Filed: April 10, 2020
    Publication date: May 12, 2022
    Inventors: Nicolas CUNIERE, Yu FAN, Sergei KOLUTUCHIN, Subha MUKHERJEE, Eric M. SIMMONS, Amarjit SINGH, Carolyn S. WEI, Yi XIAO, Changxia YUAN, Bin ZHENG, Simon Albert WAGSCHAL, Diego Fernando Domenico BROGGINI, Duy Chi Trung CAO, Kostiantyn CHERNICHENKO, Sebastien Francois Emmanuel LEMAIRE, Cyril BEN HAÏM
  • SYNTHESIS OF A BRUTON'S TYROSINE KINASE INHIBITOR
    Publication number: 20220098200
    Abstract: Described herein is the synthesis of Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one.
    Type: Application
    Filed: February 17, 2021
    Publication date: March 31, 2022
    Inventors: Cyril Ben Haim, Wei Chen, Erick Goldman, Andras Horvath, Philip Pye, Mark S. Smyth, Erik J. Verner
  • Process for the preparation of a diarylthiohydantoin compound
    Patent number: 11040953
    Abstract: Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: June 22, 2021
    Assignee: Aragon Pharmaceuticals, Inc.
    Inventors: Cyril Ben Haim, Andras Horvath, Johan Erwin Edmond Weerts, Jennifer Albaneze-Walker
  • Process For The Preparation Of A Diarylthiohydantoin Compound
    Publication number: 20200354334
    Abstract: Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.
    Type: Application
    Filed: July 27, 2020
    Publication date: November 12, 2020
    Inventors: Cyril Ben Haim, Andras Horvath, Johan Erwin Edmond Weerts, Jennifer Albaneze-Walker
  • SYNTHESIS OF A BRUTON'S TYROSINE KINASE INHIBITOR
    Publication number: 20200347064
    Abstract: Described herein is the synthesis of Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one.
    Type: Application
    Filed: December 4, 2019
    Publication date: November 5, 2020
    Inventors: Cyril Ben Haim, Wei Chen, Erick Goldman, Andras Horvath, Philip Pye, Mark S. Smyth, Erik J. Verner
  • Processes for the preparation of a diarylthiohydantoin compound
    Patent number: 10723714
    Abstract: Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: July 28, 2020
    Assignee: Aragon Pharmaceuticals, Inc.
    Inventors: Cyril Ben Haim, Andras Horvath, Johan Erwin Edmond Weerts, Jennifer Albaneze-Walker
  • SYNTHESIS OF A BRUTON'S TYROSINE KINASE INHIBITOR
    Publication number: 20190367518
    Abstract: Described herein is the synthesis of Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one.
    Type: Application
    Filed: December 18, 2018
    Publication date: December 5, 2019
    Inventors: Cyril Ben Haim, Wei Chen, Erick Goldman, Andras Horvath, Philip Pye, Mark S. Smyth, Erik J. Verner
  • Processes For The Preparation Of A Diarylthiohydantoin Compound
    Publication number: 20190284156
    Abstract: Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.
    Type: Application
    Filed: May 31, 2019
    Publication date: September 19, 2019
    Inventors: Cyril Ben Haim, Andras Horvath, Johan Erwin Edmond Weerts, Jennifer Albaneze-Walker
  • Processes for the preparation of a diarylthiohydantoin compound
    Patent number: 10316015
    Abstract: Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: June 11, 2019
    Assignee: Aragon Pharmaceuticals, Inc.
    Inventors: Cyril Ben Haim, Andras Horvath, Johan Erwin Edmond Weerts, Jennifer Albaneze-Walker
  • PROCESSES FOR THE PREPARATION OF A DIARYLTHIOHYDANTOIN COMPOUND
    Publication number: 20190135775
    Abstract: Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.
    Type: Application
    Filed: December 17, 2015
    Publication date: May 9, 2019
    Inventors: Cyril Ben Haim, Andras Horvath, Johan Erwin Edmond Weerts, Jennifer Albaneze-Walker
  • PROCESSES FOR THE PREPARATION OF A DIARYLTHIOHYDANTOIN COMPOUND
    Publication number: 20180002309
    Abstract: Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.
    Type: Application
    Filed: December 17, 2015
    Publication date: January 4, 2018
    Inventors: Cyril Ben Haim, Andras Horvath, Johan Erwin Edmond, Jennifer Albaneze-Walker
  • Process for the preparation of a diarylthiohydantoin compound
    Patent number: 9688655
    Abstract: Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: June 27, 2017
    Assignee: Janssen Pharmaceutica NV
    Inventors: Cyril Ben Haim, Andras Horvath, Johan Erwin Edmond
  • PROCESSES FOR THE PREPARATION OF A DIARYLTHIOHYDANTOIN COMPOUND
    Publication number: 20160176844
    Abstract: Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.
    Type: Application
    Filed: December 17, 2015
    Publication date: June 23, 2016
    Inventors: Cyril Ben Haim, Andras Horvath, Johan Erwin Edmond, Jennifer Albaneze-Walker
  • PROCESS FOR THE PREPARATION OF A DIARYLTHIOHYDANTOIN COMPOUND
    Publication number: 20160176845
    Abstract: Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.
    Type: Application
    Filed: December 17, 2015
    Publication date: June 23, 2016
    Inventors: Cyril Ben Haim, Andras Horvath, Johan Erwin Edmond
  • PROCESSES AND INTERMEDIATES FOR PREPARING A MEDICAMENT
    Publication number: 20150376193
    Abstract: Disclosed is a process for the preparation of the following compounds: where R1, R1a and R2a have the definitions in the description, as well as a process to prepare other intermediates that may be useful to synthesise downstream products, especially compounds that are useful as medicaments, for instance Bruton's tyrosine kinase (Btk) inhibitors such as ibrutinib. Also disclosed are other processes, other intermediates and compounds per se.
    Type: Application
    Filed: September 9, 2015
    Publication date: December 31, 2015
    Inventors: Philip PYE, Cyril BEN HAIM, Matteo CONZA, Ioannis Nicolaos HOUPIS
  • Processes and intermediates for preparing a medicament
    Patent number: 9156847
    Abstract: Disclosed is a process for the preparation of the following compounds: where R1, R1a and R2a have the definitions in the description, as well as a process to prepare other intermediates that may be useful to synthesize downstream products, especially compounds that are useful as medicaments, for instance Bruton's tyrosine kinase (Btk) inhibitors such as ibrutinib. Also disclosed are other processes, other intermediates and compounds per se.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: October 13, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Philip Pye, Cyril Ben Haim, Matteo Conza, Ioannis Nicolaos Houpis
  • PROCESSES AND INTERMEDIATES FOR PREPARING A MEDICAMENT
    Publication number: 20140275126
    Abstract: Disclosed is a process for the preparation of the following compounds: where R1, R1a and R2a have the definitions in the description, as well as a process to prepare other intermediates that may be useful to synthesise downstream products, especially compounds that are useful as medicaments, for instance Bruton's tyrosine kinase (Btk) inhibitors such as ibrutinib. Also disclosed are other processes, other intermediates and compounds per se.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Inventors: Philip PYE, Cyril BEN HAIM, Matteo CONZA, Ioannis Nicolaos HOUPIS