Abstract: Described herein is the synthesis of Bruton's tyrosine kinase (Btk) inhibitor 1-(R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) piperidin-1-yl)prop-2-en-1-one.

Abstract: A removable analog includes an analog pin having a tapered end and a location boss on the other end. A threaded tap is formed in the other end thereof. At least one flat surface is formed on a length of the analog pin to prevent rotation. At least one groove may also be formed on a length of the analog pin to prevent rotation. A second embodiment of the removable analog includes the analog pin and a sleeve. The sleeve has an internal contour which is sized to slidably receive the analog pin. One end of the sleeve has a tapered end and the other end is sized to receive the analog pin. At least one projection is formed on an exterior surface of the sleeve to prevent removal from a dental model.

Abstract: An implant screw includes a first end and a second end. A drive boss terminates a first end thereof. A first boss is formed behind the drive boss and a second boss is formed behind the first boss. A self-tapping thread is formed on a second end of the implant screw. At least one flat surface is formed along the length of the self-tapping thread. A threaded hole is formed in the first end of the implant screw. The implant abutment includes a first end and a second end. A second boss cavity is formed in the first end of the implant abutment. A first boss cavity is formed on a bottom of the second boss cavity. A drive boss cavity is formed on a bottom of the first boss cavity. A counter bore is formed through a second end of the implant abutment to receive an attachment bolt. The attachment bolt is preferably used to attach a first end of the implant screw to the first end of the implant abutment.

Abstract: An implant screw includes a first end and a second end. A drive boss terminates a first end thereof. A first boss is formed behind the drive boss and a second boss is formed behind the first boss. A self-tapping thread is formed on a second end of the implant screw. At least one flat surface is formed along the length of the self-tapping thread. A threaded hole is formed in the first end of the implant screw. The implant abutment includes a first end and a second end. A second boss cavity is formed in the first end of the implant abutment. A first boss cavity is formed on a bottom of the second boss cavity. A drive boss cavity is formed on a bottom of the first boss cavity. A counter bore is formed through a second end of the implant abutment to receive an attachment bolt. The attachment bolt is preferably used to attach a first end of the implant screw to the first end of the implant abutment.

Abstract: A method of locating a dental implant includes a locator rod. The locator rod is threaded on one end to form a threaded end and modified on the other end to form a driving end. The threaded end is screwed into a threaded hole in the dental implant. The thread of the threaded end must mate with the threaded hole in the dental implant. Preferably, a gripping surface is formed on the driving end. The gripping surface allows the locator rod to be threaded into the dental implant with the grasp of fingers. The driving end of the locator rod may be shaped to receive a hand tool such as a ratchet to rotate thereof. Once the locator rod is threaded into the dental implant, an abutment, impression coping, or any other dental item may be slid over the locator rod. The dental item is rotated relative to the dental implant until a projection seats into a cavity. The locator rod is removed from the dental implant and the dental item is secured to the dental implant with a fastener.