Abstract: Novel bispecific heterodimeric immunoglobulins that target both a component of the human CD47 antigen and human CD38 antigen are provided and in particular those comprising an anti-CD38 heavy chain variable region and a light chain variable region and an anti-CD47 heavy chain variable region and a light chain variable region. The present invention also relates to the use of this novel class of bispecific heterodimeric immunoglobulins to treat autoimmune and proliferative diseases and in particular cancers such as hematologic malignancies and solid tumors.

Abstract: Thermo-weldable coupling for connecting in particular at least two members made from an identical or compatible plastics material, comprising a body (1) which is of the type constituted at least partly by a thermo-fusible material compatible with the plastics material of these members and which comprises an inner wall (2) or connection surface, directly opposite the outer wall of the members, provided with an electrically conducting element (3). This electrically conducting element (3) is resilient and of non-rectilinear shape. Application to the connections of fluid-carrying pipes made from plastics material.