Patents by Inventor Czeslaw Radzikowski

Czeslaw Radzikowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of 1,3,2-oxazaphosphorinanes
    Patent number: 4908464
    Abstract: Process for production of derivatives of 1,3,2-oxazaphosphorinane of general formula 1, ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atom or 2-halogenoalkyl group, and R.sub.1 and R.sub.2 are not at the same time hydrogen atoms, and X represents halogen atom is based, according to the invention, on the reduction of the respective 3-halogenoacyl derivatives of 1,3,2-oxazaphosphorinane of general formula 2, ##STR2## wherein the substituents have the above given meaning. The reduction is accomplished with the use of sodium borohydride in the presence of boron trifluoride etherate.Derivatives that are prepared by the procedure described here demonstrate antitumor activity.
    Type: Grant
    Filed: June 9, 1988
    Date of Patent: March 13, 1990
    Assignees: Instytut Przemyslu Farmaceutycznego, Centrum Baden Molekularnych i Makromolekularnych -PAN, Instytut Immunologii i Terapii Doswiadczalnej -PAN
    Inventors: Wojciech J. Stec, Czeslaw Radzikowski, Wieslaw Szelejewski, Ryszard Kinas, Konrad Misiura, Grzegorz Grynkiewicz, Jacek Grodner, Halina Kusnierczyk, Andrzej Kutner, Slawomira Pilichowska
  • 1-Nitro-9-dialkylaminoisoalkylaminoacridines or their salts
    Patent number: 4150231
    Abstract: 1-Nitro-9-dialkylaminoisoalkylaminoacridines or their salts of the formula: ##STR1## wherein R is lower alkyl, such as methyl, ethyl, R.sup.1 is a hydrogen atom or methyl, R.sup.2 is the same as R.sup.1, with the proviso that R.sup.1 is not equal to R.sup.2 and n = 0 or 2, and their preparation is described. These compounds are useful as anti-neoplastic agents.
    Type: Grant
    Filed: March 25, 1977
    Date of Patent: April 17, 1979
    Assignee: Politechnika Gdanska
    Inventors: Andrzej Ledochowski, Jerzy Gieldanowski, Czeslaw Radzikowski, Cecylia Kwasniewska-Rokicinska, Barbara Wysocka-Skrzela, Lucyna Sawinska, Mieczyslaw Medon
  • 1-Nitro-9-alkylaminoalkylaminoacridines and salts thereof
    Patent number: 4139531
    Abstract: 1-Nitro-9-alkylaminoalkylaminoacridins and their salts, as well as a method for obtaining these compounds, is described. The 1-nitro-9-alkylaminoalkylaminoacridines have the formula 1, ##STR1## wherein R is methyl, ethyl, propyl, isopropyl, butyl, isobutyl, isopentyl, benzyl or cyclohexyl, whereas n is equal to 2 or 3. The salts are those derived from mineral acids or organic acids. These compounds have anti-neoplastic activity.
    Type: Grant
    Filed: February 23, 1977
    Date of Patent: February 13, 1979
    Assignee: Politechnika Gdanska
    Inventors: Andrzej Ledochowski, Jerzy Gieldanowski, Czeslaw Radzikowski, Barbara Horowska, Cecylia Kwasniewska-Rokicinska, Barbara Wysocka-Skrzela, Lucyna Sawinska, Mieczyslaw Medon