Patents by Inventor D. Bryan Prince

D. Bryan Prince has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for crystallizing human beta secretase in complex with an inhibitor
    Patent number: 7806980
    Abstract: An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure has been solved to 3.2 ? resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.
    Type: Grant
    Filed: December 28, 2005
    Date of Patent: October 5, 2010
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Timothy E. Benson, Jim D. Durbin, D. Bryan Prince
  • Crystallization and Structure Determination of Glycosylated Human Beta Secretase, an Enzyme Implicated in Alzheimer's Disease
    Publication number: 20100112665
    Abstract: An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure has been solved to 3.2 ? resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.
    Type: Application
    Filed: September 2, 2009
    Publication date: May 6, 2010
    Inventors: Timothy E. Benson, Jim D. Durbin, D. Bryan Prince
  • Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease
    Patent number: 7601528
    Abstract: An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure has been solved to 3.2 ? resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of human beta secretase activity.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: October 13, 2009
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Timothy E. Benson, Jim D. Durbin, D. Bryan Prince