Patents by Inventor D. Duan

D. Duan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF LIVER DISORDERS WITH A THR-ß AGONIST
    Publication number: 20240293416
    Abstract: Provided herein are methods for treating liver disorders, including non-alcoholic steatohepatitis, and symptoms and manifestations thereof, in a patient which utilize treatment with a THR-? agonist.
    Type: Application
    Filed: May 1, 2024
    Publication date: September 5, 2024
    Inventors: Christopher T. JONES, Kevin KLUCHER, D. Barry CRITTENDEN, Erin K. QUIRK, Feng JIN, Matt DUAN, Sheng GUO, Jianwei BIAN, Qianqian DONG
  • 47 Human Secreted Proteins
    Publication number: 20080146505
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: August 1, 2007
    Publication date: June 19, 2008
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Reinhard Ebner, Craig A. Rosen, Gregory A. Endress, Daniel R. Soppet, Jian Ni, Roxanne D. Duan, Paul A. Moore, Yanggu Shi, David W. LaFleur, Henrik S. Olsen, Kimberly A. Florence
  • Follistatin-3
    Publication number: 20070275895
    Abstract: The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
    Type: Application
    Filed: April 23, 2007
    Publication date: November 29, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: D. Duan, Steven Ruben
  • Colon Specific Gene and Protein and Cancer
    Publication number: 20070178108
    Abstract: Human Colon Specific Polynucleotides (DNA and RNA), Polypeptides, and Antibodies, as well as methods for using and producing such polynucleotides, polypeptides, and antibodies are disclosed. More particularly, methods are disclosed for utilizing such polynucleotides, polypeptides, and antibodies to detect, diagnose, prevent, treat, and/or ameliorate cancer (particularly gastrointestinal tract cancers such as colon and pancreatic cancer). Also disclosed are compositions and methods for targeting and destroying cancer cells (particularly gastrointestinal tract cancers such as colon and pancreatic cancer) via the Colon Specific Protein and/or via the Colon Specific Protein Receptor. Moreover, methods of screening for antagonists and binding partners of the Colon Specific Protein and therapeutic uses of such antagonists and binding partners are also disclosed.
    Type: Application
    Filed: April 4, 2007
    Publication date: August 2, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Patrick Dillon, Yi Li, Daniel Soppet, Adam Bell, D. Duan, Ralph Alderson, Wendy Halpern
  • 71 human secreted proteins
    Publication number: 20070014787
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: March 15, 2006
    Publication date: January 18, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, George Komatsoulis, D. Duan, Craig Rosen, Paul Moore, Yanggu Shi, David LaFleur, Reinhard Ebner, Henrik Olsen, Laurie Brewer, Kimberly Florence, Paul Young, Michael Mucenski, Gregory Endress, Daniel Soppet
  • 186 human secreted proteins
    Publication number: 20060084082
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 6, 2005
    Publication date: April 20, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Daniel Soppet, Kenneth Carter, Daniel Bednarik, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul Young, John Greene, Ann Ferrie, D. Duan, Jing-Shan Hu, Kimberly Florence, Henrik Olsen, Carrie Fischer, Reinhard Ebner, Laurie Brewer, Paul Moore, Yanggu Shi, David LaFleur, Yi Li, ZhiZhen Zeng, Hla Kyaw
  • Follistatin-3
    Publication number: 20060025341
    Abstract: The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
    Type: Application
    Filed: June 17, 2005
    Publication date: February 2, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: D. Duan, Steven Ruben
  • Antibodies against human protein HUVDJ43
    Patent number: 6953667
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: October 11, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Paul A. Moore, Steven M. Ruben, Henrik S. Olsen, Yanggu Shi, Craig A. Rosen, Kimberly A. Florence, Daniel R. Soppet, David W. LaFleur, Gregory A. Endress, Reinhard Ebner, George Komatsoulis, Roxanne D. Duan
  • 70 human secreted proteins
    Publication number: 20050215775
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: November 2, 2004
    Publication date: September 29, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven Ruben, Craig Rosen, Carrie Fischer, Daniel Soppet, Kenneth Carter, Daniel Bednarik, Gregory Endress, Guo-Liang Yu, Jian Ni, Ping Feng, Paul Young, John Greene, Ann Ferrie, D. Duan, Jing-Shan Hu, Kimberly Florence, Henrik Olsen, Reinhard Ebner, Laurie Brewer, Yanggu Shi
  • Secreted protein HCE3C63
    Patent number: 6936691
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Grant
    Filed: April 11, 2001
    Date of Patent: August 30, 2005
    Assignee: Human Genome Sciences, Inc.
    Inventors: Michele Fiscella, Ping Wei, David W. LaFleur, Henrik S. Olsen, Kevin P. Baker, Reinhard Ebner, George A. Komatsoulis, Craig A. Rosen, Steven M. Ruben, Roxanne D. Duan, Paul E. Young, Kimberly A. Florence, Paul A. Moore, Charles E. Birse, Jian Ni, Daniel R. Soppet, Yanggu Shi
  • 70 human secreted proteins
    Publication number: 20050181371
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: August 21, 2003
    Publication date: August 18, 2005
    Inventors: Craig Rosen, George Komatsoulis, Kevin Baker, Michele Fiscella, Paul Moore, Ping Wei, D. Duan, Yanggu Shi, Ram Gupta
  • 17 human secreted proteins
    Publication number: 20050032168
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: July 23, 2004
    Publication date: February 10, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Craig Rosen, George Komatsoulis, Kevin Baker, Charles Birse, Daniel Soppet, Henrik Olsen, Paul Moore, Ping Wei, Reinhard Ebner, D. Duan, Yanggu Shi, Gil Choi, Michele Fiscella, Jian Ni, Steven Ruben, Steven Barash
  • Fibroblast Growth Factor-13
    Publication number: 20050026838
    Abstract: The present invention relates to a novel human protein called Fibroblast Growth Factor 13, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
    Type: Application
    Filed: September 2, 2004
    Publication date: February 3, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: John Greene, Joachim Gruber, Craig Rosen, Ralph Alderson, Robert Melder, D. Duan
  • 52 Human secreted proteins
    Publication number: 20050019866
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: July 6, 2004
    Publication date: January 27, 2005
    Applicant: Human Genome Sciences, Inc.
    Inventors: Jian Ni, Kevin Baker, Charles Birse, Michele Fiscella, George Komatsoulis, Craig Rosen, Daniel Soppet, Paul Young, Reinhard Ebner, D. Duan, Henrik Olsen, David La Fleur, Paul Moore, Yanggu Shi, Ping Wei, Kimberly Florence
  • Fibroblast Growth Factor-10
    Publication number: 20050019824
    Abstract: The present invention relates to a novel human protein called Fibroblast Growth Factor 10, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
    Type: Application
    Filed: September 8, 2004
    Publication date: January 27, 2005
    Applicants: Human Genome Sciences, Inc., The Institute for Genomic Research
    Inventors: Ralph Alderson, Robert Melder, D. Duan, Craig Rosen, Jing-Shan Hu, Jeannine Gocayne
  • 47 human secreted proteins
    Publication number: 20040253684
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: July 7, 2004
    Publication date: December 16, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Reinhard Ebner, Craig A. Rosen, Gregory A. Endress, Daniel R. Soppet, Jian Ni, Roxanne D. Duan, Paul A. Moore, Yanggu Shi, David W. LaFleur, Henrik S. Olsen, Kimberly A. Florence
  • 64 human secreted proteins
    Publication number: 20040146893
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 15, 2003
    Publication date: July 29, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Paul E. Young, John M. Greene, Jian Ni, Ping Feng, Kimberly A. Florence, Jing-Shan Hu, Ann M. Ferrie, Guo-Liang Yu, Roxanne D. Duan, Fouad Janat
  • Fibroblast growth factor 11
    Publication number: 20040048271
    Abstract: The present invention relates to a novel human protein called Fibroblast Growth Factor 11, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
    Type: Application
    Filed: February 25, 2003
    Publication date: March 11, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Ralph Alderson, Robert J. Melder, Roxanne D. Duan, Craig A, Rosen, Jing-Shan Hu
  • 31 human secreted proteins
    Publication number: 20040048294
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: June 27, 2003
    Publication date: March 11, 2004
    Applicant: Human Genome Sciences,Inc.
    Inventors: Steven M. Ruben, Craig A. Rosen, Roxanne D. Duan, Yanggu Shi, David W. LaFleur, Paul E. Young, Jian Ni, George Komatsoulis, Gregory A. Endress, Daniel R. Soppet
  • HUMAN PROTEIN HFXJW48
    Publication number: 20040014954
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: May 15, 2002
    Publication date: January 22, 2004
    Applicant: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Paul E. Young, Laurie A. Brewer, Reinhard Ebner, Henrik S. Olsen, Kimberly A. Florence, Craig A. Rosen, Roxanne D. Duan, Paul A. Moore, Yanggu Shi, David W. LaFleur, Charles Florence, Daniel R. Soppet, Gregory A. Endress, Ping Feng, George A. Komatsoulis