Patents by Inventor D. Eugene Wampler

D. Eugene Wampler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic HbsAg derived from transformed yeast
    Patent number: 4707542
    Abstract: The surface antigen protein of human Hepatitis B virus is synthesized in Saccharomyces cerevisiae as a 23,000-26,000 dalton polypeptide, essentially free of intermolecular disulfide bonds. This antigen is a poor immunogen in animals and man. No prior precedent or method exists for efficiently converting the non-disulfide bonded antigen to a fully intermolecular disulfide bonded particle. We describe the first example of such a conversion in vitro and show that the act of this conversion enhances the immunogenicity of the antigen about 10-fold. The in vitro conversion makes practical the production of hepatitis B surface antigen from microorganisms using recombinant DNA methods.
    Type: Grant
    Filed: August 1, 1984
    Date of Patent: November 17, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Arthur Friedman, E. Dale Lehman, William J. McAleer, Ted F. Schaefer, Edward M. Scolnick, D. Eugene Wampler
  • Separation of hepatitis B surface antigen
    Patent number: 4349539
    Abstract: Fluid containing hepatitis B surface antigen (HBsAg) is concentrated and separated from contaminating material by ultrafiltration before undergoing further processing to isolate HBsAg.
    Type: Grant
    Filed: August 15, 1980
    Date of Patent: September 14, 1982
    Assignee: Merck & Co., Inc.
    Inventor: D. Eugene Wampler