Patents by Inventor D. Grant McFadden

D. Grant McFadden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Viral Sequences and Uses Thereof
    Publication number: 20110288004
    Abstract: The invention features polypeptide and polynucleotide sequences based on the 134R sequence. In some embodiments, these sequences include a heterologous signal sequence, such as the myxoma virus T7 signal sequence. The invention also features methods for treating immunological disorders and neoplasms (e.g., cancer) using the polypeptides and nucleotides described herein. Finally, the invention features fusion proteins including the myxoma virus T7 signal sequence.
    Type: Application
    Filed: June 21, 2007
    Publication date: November 24, 2011
    Inventors: D. Grant McFadden, Alexandra R. Lucas, John W. Barrett
  • Method for treating transplant rejection
    Patent number: 7906483
    Abstract: Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an anti-rejection agent, such as cyclosporin, and a pharmaceutically acceptable carrier to a subject in need of such treatment. The compositions and methods are useful for treating acute and chronic allograft and xenograft transplant rejection in mammals.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: March 15, 2011
    Assignee: Viron Therapeutics Inc.
    Inventors: Alexandra Lucas, Z. Robert Zhong, D. Grant McFadden
  • Method for treating transplant rejection
    Publication number: 20090221472
    Abstract: Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an anti-rejection agent, such as cyclosporin, and a pharmaceutically acceptable carrier to a subject in need of such treatment. The compositions and methods are useful for treating acute and chronic allograft and xenograft transplant rejection in mammals.
    Type: Application
    Filed: February 23, 2009
    Publication date: September 3, 2009
    Inventors: Alexandra Lucas, Z. Robert Zhong, D. Grant McFadden
  • Methods for treating transplant rejection
    Patent number: 7514405
    Abstract: Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an anti-rejection agent, such as cyclosporin, and a pharmaceutically acceptable carrier to a subject in need of such treatment. The compositions and methods are useful for treating acute and chronic allograft and xenograft transplant rejection in mammals.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: April 7, 2009
    Assignee: Viron Therapeutics Inc.
    Inventors: Alexandra Lucas, Robert Zhong, D. Grant McFadden
  • Methods for treating transplant rejection
    Publication number: 20030171263
    Abstract: Compositions and methods for treating transplant rejection in a mammalian transplant recipient are provided. The method involves administering a therapeutically effective amount of Serp-1, its analogs, and biologically active fragments thereof in combination with an anti-rejection agent, such as cyclosporin, and a pharmaceutically acceptable carrier to a subject in need of such treatment. The compositions and methods are useful for treating acute and chronic allograft and xenograft transplant rejection in mammals.
    Type: Application
    Filed: March 13, 2003
    Publication date: September 11, 2003
    Applicant: Viron Therapeutics, Inc.
    Inventors: Alexandra Lucas, Robert Zhong, D. Grant McFadden
  • Methods of treating inflammation and compositions therefor
    Patent number: 5939525
    Abstract: Compositions and methods for treating inflammatory cell infiltration in a tissue of a mammalian subject are provided. The method involves administering a therapeutically effective amount of SERP-1, SERP-1 analog or biologically active fragment thereof admixed with a pharmaceutically acceptable carrier to a subject in need of such treatment. Biologically active SERP-1 analogs are also provided. The compositions and methods of the present invention are useful for treating numerous inflammatory based diseases and injuries.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: August 17, 1999
    Assignee: Viron Therapeutics, Inc.
    Inventors: D. Grant McFadden, Alexandra Lucas
  • Methods of treating inflammation and compositions therefor
    Patent number: 5917014
    Abstract: Compositions and methods for treating inflammatory cell infiltration in a tissue of a mammalian subject are provided. The method involves administering a therapeutically effective amount of SERP-1, SERP-1 analog or biologically active fragment thereof admixed with a pharmaceutically acceptable carrier to a subject in need of such treatment. Biologically active SERP-1 analogs are also provided. The compositions and methods of the present invention are useful for treating numerous inflammatory based diseases and injuries.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 29, 1999
    Assignee: Viron Therapeutics, Inc.
    Inventors: D. Grant McFadden, Alexandra Lucas
  • Antirestenosis protein
    Patent number: 5686409
    Abstract: A method of treating primary and recurrent atheromatous plaque development is provided. The method involves administering a therapeutically effective amount of SERP-1, admixed in a pharmaceutically acceptable carrier to the intimal or lumenal layer of arterial walls. Biologically active SERP-1 analogs are also provided.
    Type: Grant
    Filed: May 2, 1994
    Date of Patent: November 11, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: D. Grant McFadden, Alexandra Lucas