Patents by Inventor D. James Morre

D. James Morre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6361961
    Abstract: A method and apparatus for sensing gravity using an NADH oxidase of the plasma membrane which has been found to respond to unit gravity and low centrifugal g forces. The oxidation rate of NADH supplied to the NADH oxidase is measured and translated to represent the relative gravitational force exerted on the protein. The NADH oxidase of the plasma membrane may be obtained from plant or animal sources or may be produced recombinantly.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: March 26, 2002
    Assignee: The United States of America as represented by the National Aeronautics and Space Administration
    Inventor: D. James Morreā€²
  • Publication number: 20020019439
    Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
    Type: Application
    Filed: April 16, 1999
    Publication date: February 14, 2002
    Inventors: PAUL A. GRIECO, D. JAMES MORRE, THOMAS H. CORBETT, FREDERICK A. VALERIOTE
  • Patent number: 5965493
    Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: October 12, 1999
    Assignees: Advanced Research and Technology Institute, Inc., The Board of Governors of Wayne State University, Purdue Reseach Foundation
    Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
  • Patent number: 5883048
    Abstract: Thiol compounds are employed in conjunction with compounds which modulate self proliferation, both as to plants and mammals. The thiol compounds find effect in enhancing the effectiveness of auxin like compounds, either as herbicides or in enhancing root formation. In addition, thiol compounds act in conjunction with cytotoxic agents in mammals to allow for lower dosages of the cytotoxic agents while retaining the cytotoxic effect against hyperproliferative diseases, such as cancer. The combination finds particular effect against cells dependent upon an isoform of a surface membrane NADH oxidase for proliferation.
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: March 16, 1999
    Assignee: Purdue Research Foundation
    Inventors: D. James Morre, Guy Auderset, Charles Moncousin
  • Patent number: 5849748
    Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: December 15, 1998
    Assignee: Advanced Research and Technology Institute, Inc.
    Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
  • Patent number: 5643853
    Abstract: Thiol compounds are employed in conjunction with compounds which modulate self proliferation, both as to plants and mammals. The thiol compounds find effect in enhancing the effectiveness of auxin like compounds, either as herbicides or in enhancing root formation. In addition, thiol compounds act in conjunction with cytotoxic agents in mammals to allow for lower dosages of the cytotoxic agents while retaining the cytotoxic effect against hyperproliferative diseases, such as cancer. The combination finds particular effect against cells dependent upon an isoform of a surface membrane NADH oxidase for proliferation.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: July 1, 1997
    Assignee: Purdue Research Foundation
    Inventor: D. James Morre
  • Patent number: 5639712
    Abstract: Quassinoid compounds, compositions, and methods of using them for treating cells and solid tumors, and inhibiting plant growth.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: June 17, 1997
    Assignees: Indiana University Foundation, Purdue Research Foundation, Bd. of Governors of Wayne State Univ.
    Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
  • Patent number: 5569673
    Abstract: N-Acylated catecholmethylamines are used to inhibit cancer cell proliferation. Specifically, capsaicin is found to inhibit growth at low concentration, but not normal cells.
    Type: Grant
    Filed: May 24, 1994
    Date of Patent: October 29, 1996
    Assignee: Purdue Research Foundation
    Inventors: D. James Morre, Dorothy M. Morre
  • Patent number: 4115062
    Abstract: In humans and experimental animals, serum levels of sialic acid-containing glycolipids are elevated 1.5 to 3 fold. A method is described whereby the ganglioside content is estimated on as little as 0.5 ml of serum or plasma. The procedure permits, based on the analysis of a single biochemical parameter, cancer detection applicable to a wide range of human and animal tumor types.
    Type: Grant
    Filed: June 13, 1977
    Date of Patent: September 19, 1978
    Assignee: Purdue Research Foundation
    Inventors: D. James Morre, Thomas M. Kloppel, Thomas W. Keenan