Patents by Inventor D. Kyle Pierce
D. Kyle Pierce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230172975Abstract: The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension.Type: ApplicationFiled: March 30, 2022Publication date: June 8, 2023Applicant: GR Intellectual Reserve, LLCInventors: Adam R. Dorfman, David A. Bryce, Maxwell A. Grace, D. Kyle Pierce, Mikhail Merzliakov, Mark G. Mortenson
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Publication number: 20210361699Abstract: The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions.Type: ApplicationFiled: April 13, 2021Publication date: November 25, 2021Applicant: Clene Nanomedicine, Inc.Inventors: Mark Gordon Mortenson, D. Kyle Pierce, David A. Bryce, Reed N. Wilcox, Anthony Lockett, Mikhail Merzliakov
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Publication number: 20210236542Abstract: The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions.Type: ApplicationFiled: April 6, 2021Publication date: August 5, 2021Applicant: Clene Nanomedicine, Inc.Inventors: Mark Gordon Mortenson, D. Kyle Pierce, David A. Bryce, Reed N. Wilcox, Anthony Lockett, Mikhail Merzliakov
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Patent number: 10980832Abstract: The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions.Type: GrantFiled: August 8, 2019Date of Patent: April 20, 2021Assignee: Clene Nanomedicine, Inc.Inventors: Mark Gordon Mortenson, D. Kyle Pierce, David A. Bryce, Reed N. Wilcox, Anthony Lockett, Mikhail Merzliakov
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Publication number: 20200188429Abstract: The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions.Type: ApplicationFiled: August 8, 2019Publication date: June 18, 2020Applicant: Clene Nanomedicine, Inc.Inventors: Mark Gordon Mortenson, D. Kyle Pierce, David A. Bryce, Reed N. Wilcox, Anthony Lockett, Mikhail Merzliakov
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Patent number: 10449217Abstract: The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions.Type: GrantFiled: March 21, 2017Date of Patent: October 22, 2019Assignee: Clene Nanomedicine, Inc.Inventors: Mark Gordon Mortenson, D. Kyle Pierce, David A. Bryce, Reed N. Wilcox, Anthony Lockett, Mikhail Merzliakov
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Publication number: 20170348350Abstract: The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions.Type: ApplicationFiled: March 21, 2017Publication date: December 7, 2017Applicant: Clene Nanomedicine, Inc.Inventors: Mark Gordon Mortenson, D. Kyle Pierce, David A. Bryce, Reed N. Wilcox, Anthony Lockett, Mikhail Merzliakov
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Patent number: 9603870Abstract: The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals.Type: GrantFiled: July 8, 2010Date of Patent: March 28, 2017Inventors: Mark Gordon Mortenson, D. Kyle Pierce, David A. Bryce, Adam R. Dorfman, Reed N. Wilcox, Anthony Lockett, Mikhail Merzliakov
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Publication number: 20160317578Abstract: The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension.Type: ApplicationFiled: July 7, 2016Publication date: November 3, 2016Applicant: GR Intellectual Reserve, LLCInventors: Adam R. Dorfman, David A. Bryce, Maxwell A. Grace, D. Kyle Pierce, Mikhail Merzliakov, Mark G. Mortenson
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Patent number: 9387225Abstract: The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension.Type: GrantFiled: March 30, 2012Date of Patent: July 12, 2016Inventors: Adam R. Dorfman, David A. Bryce, Maxwell A. Grace, D. Kyle Pierce, Mikhail Merzliakov, Mark G. Mortenson
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Publication number: 20140294963Abstract: The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension.Type: ApplicationFiled: March 30, 2012Publication date: October 2, 2014Inventors: Adam R Dorfman, David A. Bryce, Maxwell A. Grace, D. Kyle Pierce, Mikhail Merzliatov, Mark G. Mortenson
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Publication number: 20130259903Abstract: The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals.Type: ApplicationFiled: July 8, 2010Publication date: October 3, 2013Inventors: Mark Gordon Mortenson, D. Kyle Pierce, David A. Bryce, Adam R. Dorfman, Reed N. Wilcox, Anthony Lockett, Mikhail Merzliakov