Patents by Inventor D. Leysen

D. Leysen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Etonogestrel esters
    Patent number: 7323454
    Abstract: The subject invention provides new progestogen esters and uses thereof.
    Type: Grant
    Filed: May 22, 2003
    Date of Patent: January 29, 2008
    Assignee: N.V. Organon
    Inventors: Henrik H De Nijs, Hendrikus Adrianus Antonius H.A.A. Van Der Voort, Dirk D. Leysen, Arij Jan A.J. Grootenhuis
  • 14-?, 17-?-hydroxymethylandrostane derivatives as androgens
    Patent number: 6881728
    Abstract: Androgenic steroids having a (14?,17?-)-17-(hydroxymetheyl) configuration, useful for the preparation of male contraceptives and pharmaceutical formulations for the treatment of androgen insufficiency.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: April 19, 2005
    Assignee: Akzo Nobel N.V.
    Inventors: Hubert Jan Jozef Loozen, Dirk D. Leysen, Jaap van der Louw
  • Testosterone derivative
    Publication number: 20040033999
    Abstract: The invention is the novel androgen (7&agr;,17&bgr;)-7-methyl-17-[(1-oxoundecyl)oxy]estr-4en-3one (MENT undecanoate). This compound distinguishes favourably from other testosterone derivatives in that it has a good solubility in oily media. It particularly exhibits a good dissolved potency relative to testosterone. The compound is particularly suitable for administration by means of injection.
    Type: Application
    Filed: June 21, 2002
    Publication date: February 19, 2004
    Inventors: Dirk D. Leysen, Hendrikus Adrianus Antonius Van Der Voort H.A.A.
  • 22s-hydroxycholesta-8, 14-diene derivatives with meiosis regulating activity
    Patent number: 6528501
    Abstract: The invention relates to 22S hydroxycholesta-8, 14-diene derivatives having general formula (I) wherein R1 is OR, OSO3H or —NOR; with R being H, (C1-6)alkyl or (C1-6)acyl; each of R2 and R3 is independently hydrogen or (C1-6)alkyl; R4 is hydrogen, (C1-6)alkyl or (C1-6)acyl; R5 is hydrogen; or R5 designates, together with R6, an additional bond between the carbon atoms at which R5 and R6 are placed; R6 is hydrogen, hydroxy or halogen, or R6 designates, together with R5, an additional bond between the carbon atoms at which R6 and R5 are placed; each or R7 and R8 is independently hydrogen or (C1-4)alkyl, optionally substituted with OH, (C1-4)alkoxy, or halogen; or a pharmaceutically acceptable salt thereof. The compounds of the invention have meiosis activating activity and can be used for the control of fertility.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: March 4, 2003
    Assignee: Akzo Nobel N.V.
    Inventors: Dirk D. Leysen, Jaap J. van der Louw, Robert Gerard Jules Marie Hanssen, A. Anja Wiersma
  • 22R-hydroxycholesta-8, 14-diene derivatives for the inhibition of meiosis
    Patent number: 6518262
    Abstract: The invention relates to 22R-hydroxycholesta-8,14-diene derivatives having general formula (I) wherein R1 is OR, OS03H or ═NOR; with R being H, (C1-6)alkyl or (C1-6)acyl; each of R2 and R3 is independently hydrogen or (C1-6)alkyl; R4 is hydrogen, (C1-6)alkyl or (C1-6)acyl; R5 is hydrogen; or R5 designates, together with R6, an additional bond between the carbon atoms at which R5 and R6 are placed; R6 is hydrogen, hydroxy or halogen; or R6 designates, together with R5, an additional bond between the carbon atoms at which R6 and R5 are placed; each of R7 and R8 is independently hydrogen or (C1-4)alkyl, optionally substituted with OH, (C1-4)alkoxy, or halogen; or a pharmaceutically acceptable salt thereof. The compounds of the invention have meiosis inhibiting activity and can be used for the control of fertility.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: February 11, 2003
    Assignee: Akzo Nobel N.V.
    Inventors: D. Leysen, J. van der Louw, R. G. J. M. Hanssen, Anja Wiersma