Abstract: A multifunctional transfer set having an access port is disclosed. The multifunctional transfer set facilitates the introduction of elongate members insertably/retractably and allows fluid flow therethrough without requiring detachment during use. The multifunctional transfer set has a transfer set body assembly connected to a Y-adapter with an access port and a longitudinal portion. A longitudinal axis extends through the transfer set body assembly and longitudinal portion of the Y-adapter and not through the access port. An extension sub-assembly is connected to the access port, the extension sub-assembly having branch tubing, a flow-control device, and a coupling assembly allows fluid flow therethrough into and out of the transfer set body assembly if the flow-control device is open and prevents fluid from flowing therethrough if the flow-control device is closed.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

Abstract: An electromagnetic radiation (EMR) delivery system for delivering EMR at wavelengths, intensities, exposures, and durations to locations inside and/or outside a patient's body in, on, and surrounding a tubular structure such as a tube, catheter, and/or a catheter extension to prevent, reduce, and/or eliminate infectious agents in, on, or surrounding the tubular structure. A smart light engine box generates the therapeutic EMR, controls treatments, and monitors the health of the system. A fiber optic disposable makes at-home use of the EMR delivery system possible. Specific embodiments of the EMR delivery system for use with peritoneal dialysis catheters, dialysis accesses, and hemodialysis accesses are also disclosed.

Abstract: An introducer assembly introduces an elongate member into a tubular structure and may be configured into ready, introduced, and detached modes. The introducer assembly has a guide tube, a slide collar, and proximal and distal connector assemblies. The guide tube has a proximal body, and a distal portion, the distal portion being rotatably connected to the proximal body. The slide collar has a grip, a slide post, and a centered capture structure. The proximal connector assembly is detachably nested within the centered capture structure. The distal connector assembly is detachably nested within the distal portion and is connectable to the tubular structure. The introducer assembly may be converted from the ready mode to the introduced mode to the detached mode by manual manipulation to introduce and secure the elongate member within the connected tubular structure, and then detach the guide tube leaving the elongate member within the connected tubular structure.

Abstract: An electromagnetic radiation (EMR) delivery system for delivering EMR at wavelengths, intensities, exposures, and durations to locations inside and/or outside a patient's body in, on, and surrounding a tubular structure such as a tube, catheter, and/or a catheter extension to prevent, reduce, and/or eliminate infectious agents in, on, or surrounding the tubular structure. A smart light engine box generates the therapeutic EMR, controls treatments, and monitors the health of the system. A fiber optic disposable, introduced and positioned by an introducer assembly, makes at-home use of the EMR delivery system possible. Specific embodiments of the EMR delivery system for use with peritoneal dialysis catheters, dialysis accesses, and hemodialysis accesses are also disclosed.

Abstract: Methods, apparatuses, and systems are presented for generating natural language models using a novel system architecture for feature extraction. A method for extracting features for natural language processing comprises: accessing one or more tokens generated from a document to be processed; receiving one or more feature types defined by user; receiving selection of one or more feature types from a plurality of system-defined and user-defined feature types, wherein each feature type comprises one or more rules for generating features; receiving one or more parameters for the selected feature types, wherein the one or more rules for generating features are defined at least in part by the parameters; generating features associated with the document to be processed based on the selected feature types and the received parameters; and outputting the generated features in a format common among all feature types.

Abstract: Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.

Abstract: The invention provides compounds of formula (I): or pharmaceutically-acceptable salts thereof, that are inhibitors of Janus kinases and release an active metabolite in vivo. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat inflammatory skin diseases and other diseases.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

Abstract: Systems, methods, and apparatuses are presented for a novel natural language tokenizer and tagger. In some embodiments, a method for tokenizing text for natural language processing comprises: generating from a pool of documents, a set of statistical models comprising one or more entries each indicating a likelihood of appearance of a character/letter sequence in the pool of documents; receiving a set of rules comprising rules that identify character/letter sequences as valid tokens; transforming one or more entries in the statistical models into new rules that are added to the set of rules when the entries indicate a high likelihood; receiving a document to be processed; dividing the document to be processed into tokens based on the set of statistical models and the set of rules, wherein the statistical models are applied where the rules fail to unambiguously tokenize the document; and outputting the divided tokens for natural language processing.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: The invention provides compounds which are prodrugs of a JAK inhibitor agent for the targeted delivery of the JAK inhibitor to the gastrointestinal tract of a mammal. The invention also provides pharmaceutical compositions comprising the compounds, methods of using the compounds to treat gastrointestinal inflammatory diseases, and processes and intermediates useful for preparing the compounds.

Abstract: An electromagnetic radiation (EMR) delivery system for delivering EMR at wavelengths, intensities, exposures, and durations to locations inside and/or outside a patient’s body in, on, and surrounding a tubular structure such as a tube, catheter, and/or a catheter extension to prevent, reduce, and/or eliminate infectious agents in, on, or surrounding the tubular structure. A smart light engine box generates the therapeutic EMR, controls treatments, and monitors the health of the system. A fiber optic disposable makes at-home use of the EMR delivery system possible. Specific embodiments of the EMR delivery system for use with peritoneal dialysis catheters, dialysis accesses, and hemodialysis accesses are also disclosed.

Abstract: Systems and methods are presented for the automatic placement of rules applied to topics in a logical hierarchy when conducting natural language processing. In some embodiments, a method includes: accessing, at a child node in a logical hierarchy, at least one rule associated with the child node; identifying a percolation criterion associated with a parent node to the child node, said percolation criterion indicating that the at least one rule associated with the child node is to be associated also with the parent node; associating the at least one rule with the parent node such that the at least one rule defines a second factor for determining whether the document is to also be classified into the parent node; accessing the document for natural language processing; and determining whether the document is to be classified into the parent node or the child node based on the at least one rule.

Abstract: A flow cytometer can include: at least one light emitter configured to emit light in a light path; a rectangular flow cell having flow cell width that is substantially lateral to the light path and a flow cell depth that is longitudinal to the light path, wherein the light path has an interrogation width at the flow cell that is narrower than the flow cell width; and a spherical reflector positioned adjacent to the rectangular flow cell and having a concave reflective surface that has a reflective direction that is positioned substantially orthogonal with the light path such that reflected light is reflected along a reflected path that is substantially orthogonal with the light path. At least one light absorbing member is positioned at least partially around the reflected path to absorb reflected light at an angle to the reflected path.

Abstract: A subassembly for efficiently and reliably assembling a high performance electronic device. The electronic device may include numerous cabled interconnects in a subassembly that is subsequently mechanically and electrically connected to a PCB populated with high performance electronic components. First ends of cables in the cabled interconnects may be terminated by a first type of connector configured for connection to the PCB via a downward force. The second ends of the cables may be terminated with a second type of connectors that may make connections to other portions of an electronic system incorporating the electronic device. The connectors at the first ends of the cables may be releasably held within an organizer. The connectors may be simply mounted to the PCB by positioning the organizer with respect to the PCB, releasing the connectors from the organizer, and pushing the connectors into engagement with mounting locations on the PCB.