Patents by Inventor D. Michael Olive

D. Michael Olive has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220378949
    Abstract: Neurotrophin receptor binding conjugate compositions for delivering an active agent to nerve cells are provided. Conjugate compositions of the present disclosure according to certain embodiments include a one or more active agent compounds (e.g., a dye or small molecule therapeutic) covalently bonded to a protein, peptide or peptidomimetic that binds selectively to a neurotrophin receptor. In embodiments of the compositions, the average ratio of active agent compound to protein, peptide or peptidomimetic in the conjugates is 5 or less. Dual color imaging compositions are also described. Methods for delivering an active agent conjugate selectively into nerve cells (e.g., intraocular delivery) are provided.
    Type: Application
    Filed: October 22, 2020
    Publication date: December 1, 2022
    Inventors: CONSTANCE A. MCKEE, STEPHEN B. KAHL, D. MICHAEL OLIVE, GORDON CRAIG HILL, LOUIS EUGENE BURTON
  • Publication number: 20130052637
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
    Type: Application
    Filed: August 29, 2012
    Publication date: February 28, 2013
    Applicant: LI-COR, INC.
    Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
  • Patent number: 8303936
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: November 6, 2012
    Assignee: Li-Cor, Inc.
    Inventors: Daniel R. Draney, Ananda G. Lugade, Narasimhachari Narayanan, Joy Kovar, D. Michael Olive
  • Publication number: 20120258048
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
    Type: Application
    Filed: June 15, 2012
    Publication date: October 11, 2012
    Applicant: LI-COR, INC.
    Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
  • Patent number: 7597878
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: October 6, 2009
    Assignee: Li-Cor, Inc.
    Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
  • Patent number: 5464773
    Abstract: An improved apparatus for effectively disrupting biological samples contained in cuvettes to which beads have been added. In the apparatus, a special arm/bearing subassembly is driven and oscillated by a motor in a manner to attain cellular disruption of the biological samples without degradation of their cellular components. In the preferred form, the special arm/bearing subassembly has a cam, bearings, and a bearing sleeve which cooperate with a motor drive shaft to rotate a yoke with two arms holding four cuvettes. For increased safety and environmental protection, special sample retainers can be provided to better secure the cuvettes and the arm/bearing subassembly is enclosed in a sample chamber which provides a secondary containment compartment that contain any spillage.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: November 7, 1995
    Assignee: Amoco Corporation
    Inventors: Luis A. Melendez, Robert E. Rosenbaum, Marcela A. Vera-Garcia, D. Michael Olive, John E. Swenson