Abstract: Devices and methods for accessing and closing vascular sites are disclosed. Self-sealing closure devices and methods are disclosed. A device that can make both steeply sloping and flat access paths into a vascular lumen is disclosed. The device can also form arteriotomies with sections cleaved between a vessel's intima and adventitia. Methods for using the device are also disclosed.

Abstract: A notched catheter has a lumen and a notched outer surface intersecting the lumen with a filament-containing layer adjacent to the outer surface. A part of the filament-containing layer is capturable between the notched surface portion and an elongate element extendable through the lumen.

Abstract: Devices, systems, and methods for suturing of body lumens allow the suturing of vascular puncture sites located at the distal end of a percutaneous tissue tract. An elongated articulated foot is inserted through a penetration and actuated extend the foot carrying suturing attachment cuffs. Needles are advanced from the shaft through the vessel wall outside of the penetration and into engagement with the needle cuffs after the foot has been drawn proximally up against the endothelial surface of the blood vessel. The cuffs lockingly engage the needles and can be withdrawn along the needle paths and through the tissue tract to form a loop of suture across the puncture. The articulating foot may be realigned with the shaft and withdrawn proximally through the tissue tract without dilating the tissue tract.

Abstract: Devices and methods for accessing and closing vascular sites are disclosed. Self-sealing closure devices and methods are disclosed. A device that can make both steeply sloping and flat access paths into a vascular lumen is disclosed. The device can also form arteriotomies with sections cleaved between a vessel's intima and adventitia. Methods for using the device are also disclosed.

Abstract: Devices and methods for accessing and closing vascular sites are disclosed. Self-sealing closure devices and methods are disclosed. A device that can make a steep and controlled access path into a vascular lumen is disclosed. Methods for using the device are also disclosed.

Abstract: Devices and methods for accessing and closing vascular sites are disclosed. Self-sealing closure devices and methods are disclosed. A device that can make a steep and controlled access path into a vascular lumen is disclosed. Methods for using the device are also disclosed.

Abstract: Devices and methods for accessing and closing vascular sites are disclosed. Self-sealing closure devices and methods are disclosed. A device that can make a steep and controlled access path into a vascular lumen is disclosed. Methods for using the device are also disclosed.

Abstract: Devices and methods for accessing and closing vascular sites are disclosed. Self-sealing closure devices and methods are disclosed. A device that can make a steep and controlled access path into a vascular lumen is disclosed. Methods for using the device are also disclosed.

Abstract: Devices and methods for accessing and closing vascular sites are disclosed. Self-sealing closure devices and methods are disclosed. A device that can make a steep and controlled access path into a vascular lumen is disclosed. Methods for using the device are also disclosed.

Abstract: Devices and methods for accessing and closing vascular sites are disclosed. Self-sealing closure devices and methods are disclosed. A device that can make both steeply sloping and flat access paths into a vascular lumen is disclosed. The device can also form arteriotomies with sections cleaved between a vessel's intima and adventitia. Methods for using the device are also disclosed.

Abstract: A vascular lining removal assembly comprises a plurality of slats, each having inner and outer surfaces, configured to pass along a vascular cleavage plane to removingly engage a length of vascular lining. In some embodiments the assembly may also include means for engaging the length of vascular lining to aid removal of the length of vascular lining. The inner surface of at least one of the slats may comprise an inwardly opening passageway to permit direct access to the length of vascular lining by a tool.

Abstract: A tissue separation apparatus is disclosed. The apparatus can have a separating member that has a contracted state and an expanded state. When the separating member is placed between first and second tissue layers, the separating member can part the first tissue layer from the second tissue layer. The separating member can be moved into the contracted state to sever the first tissue layer. Methods of making and using the prosthesis are also disclosed.

Abstract: Devices, systems, and methods for suturing of body lumens allow the suturing of vascular puncture sites located at the distal end of a percutaneous tissue tract. An elongated articulated foot near a distal end of a shaft is inserted through the penetration and actuated so that the foot extends along the lumenal axis. The foot carries suturing attachment cuffs, and needles are advanced from the shaft through the vessel wall outside of the penetration and into engagement with the needle cuffs after the foot has been drawn proximally up against the endothelial surface of the blood vessel. The cross-section of the shaft within the tissue tract can be minimized by laterally deflecting the needles as they leave the shaft, while tapered depressions within the foot can guide the advancing needles into engagement with the cuffs. The cuffs lockingly engage the needles and can be withdrawn proximally along the needle paths and through the tissue tract so as to form a loop of suture across the puncture.

Abstract: A delivery catheter comprises a first, flexible, polymer-based tube and a second, metal tube at the first tube distal end. The second tube has flexibility enhancing relief areas along its length to provide localized areas of reduced bending stiffness to enhance the bending flexibility while retaining good torsional stiffness. A notched catheter has a lumen and a notched outer surface intersecting the lumen with a filament-containing layer adjacent to the outer surface. A part of the filament-containing layer is capturable between the notched surface portion and an elongate element extendable through the lumen. A generally helically coiled endoluminal prosthesis may be mounted on a pre-torqued delivery catheter to tighten the coiled endoluminal prosthesis onto the delivery catheter.

Abstract: A coiled endoluminal prosthesis system may include means for rotating a delivery catheter while axially releasing a coiled endoluminal prosthesis from the delivery catheter. A release element may be retracted simultaneously with rotation of the delivery catheter. The coiled endoluminal prosthesis may have a first direction of spiral in a first rotational direction. The delivery catheter may be rotated in a second rotational direction while axially releasing the coiled endoluminal prosthesis from the delivery catheter. The endoluminal prosthesis may be configured to reduce or eliminate any difference between the length of the endoluminal prosthesis when in the reduced diameter state and when in the expanded diameter state.

Abstract: An intravascular implant and methods of using the implant within the vasculature of the body, for example near a vascular aneurysm, are disclosed. The method of attaching a second implant, such as a vascular graft, to the intravascular implant is also disclosed. The implant can be made from an anchor, a connector and a seal.

Abstract: Devices, systems, and methods for suturing of body lumens allow the suturing of vascular puncture sites located at the distal end of a percutaneous tissue tract. An elongated articulated foot near a distal end of a shaft is inserted through the penetration and actuated so that the foot extends along the lunenal axis. The foot carries suturing attachment cuffs, and needles are advanced from the shaft through the vessel wall outside of the penetration and into engagement with the needle cuffs after the foot has been drawn proximally up against the endothelial surface of the blood vessel. The cross-section of the shaft within the tissue tract can be minimized by laterally deflecting the needles as they leave the shaft, while tapered depressions within the foot can guide the advancing needles into engagement with the cuffs. The cuffs lockingly engage the needles and can be withdrawn proximally along the needle paths and through the tissue tract so as to form a loop of suture across the puncture.

Abstract: Devices and methods for biological tissue closure are disclosed. Arteriotomy closure and hemostasis devices and methods are disclosed. A device that can provide a lateral tension across an opening in the tissue and apply energy to seal the tissue is disclosed. Methods for using the device are also disclosed.

Abstract: Devices and methods for accessing and closing vascular sites are disclosed. Self-sealing closure devices and methods are disclosed. A device that can make a steep and controlled access path into a vascular lumen is disclosed. Methods for using the device are also disclosed.

Abstract: A device for releasably attaching to an elongated element is disclosed. Examples of the elongated element include a shaft, such as a guidewire. The device can improve the ergonomics of manipulating the elongated element. The device can also be easily put onto and removed from the guidewire. The invention also relates to a method of using the device.