Patents by Inventor D. Phillip Cox

D. Phillip Cox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective reduction of morphinan alkaloids
    Patent number: 10155771
    Abstract: The present disclosure relates to selective reduction of morphinan alkaloids in a continuous flow system. In particular, the present disclosure relates to selective reduction of thebaine or oripavine using hydrazine or a hydrazine-containing compound in a continuous flow system under elevated temperature and pressure condition to form 8,14-dihydrothebaine or 8,14-dihydrooripavine, respectively.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: December 18, 2018
    Assignee: Noramco, Inc.
    Inventors: D. Phillip Cox, C. Oliver Kappe, Bartholomaus Pieber
  • SELECTIVE REDUCTION OF MORPHINAN ALKALOIDS
    Publication number: 20170137432
    Abstract: The present disclosure relates to selective reduction of morphinan alkaloids in a continuous flow system. In particular, the present disclosure relates to selective reduction of thebaine or oripavine using hydrazine or a hydrazine-containing compound in a continuous flow system under elevated temperature and pressure condition to form 8,14-dihydrothebaine or 8,14-dihydrooripavine, respectively.
    Type: Application
    Filed: November 4, 2016
    Publication date: May 18, 2017
    Applicant: Noramco Inc.
    Inventors: D. Phillip Cox, C. Oliver Kappe, Bartholomaus Pieber
  • Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
    Patent number: 8058439
    Abstract: The present invention is directed to processes for preparing oxycodone base and oxycodone hydrochloride compositions having less than 10 ppm of 14-hydroxycodeinone.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: November 15, 2011
    Assignee: Noramco, Inc.
    Inventors: D. Phillip Cox, Yong Zhang, Wen-Chun Zhang, Karen E. James
  • Methods for one-pot -demethylation/-acylation of morphine and tropane alkaloids
    Patent number: 7999104
    Abstract: The present invention provides a method for the N-demethylation and/or N-acylation of an N-methylated heterocycle such as morphine alkaloids or tropane alkaloids. The method comprises reacting the heterocycle with an acylating agent in the presence of a metal catalyst.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: August 16, 2011
    Assignee: Brock University
    Inventors: Robert James Carroll, Hannes Leisch, Tomas Hudlicky, D. Phillip Cox
  • PROCESS FOR PREPARING OXYCODONE HAVING REDUCED LEVELS OF 14- HYDROXYCODEINONE
    Publication number: 20110144340
    Abstract: The present invention is directed to processes for preparing oxycodone base and oxycodone hydrochloride compositions having less than 10 ppm of 14-hydroxycodeinone.
    Type: Application
    Filed: January 20, 2011
    Publication date: June 16, 2011
    Inventors: D. Phillip Cox, Yong Zhang, Wen-Chun Zhang, Karen E. James
  • Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
    Patent number: 7906647
    Abstract: The present invention is directed to processes for preparing oxycodone base and oxycodone hydrochloride compositions having less than 10 ppm of 14-hydroxycodeinone.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: March 15, 2011
    Assignee: Noramco, Inc.
    Inventors: D. Phillip Cox, Yong Zhang, Wen-Chun Zhang, Karen E. James
  • Process for reducing impurities in oxycodone base
    Patent number: 7875719
    Abstract: The present invention is directed to a process for using n-butanol to prepare an oxycodone base compositions having reduced levels of impurities such as 14-hydroxycodeinone and DHDHC.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: January 25, 2011
    Inventors: D. Phillip Cox, Yong Zhang
  • PROCESS FOR PREPARING PARTICLES OF OPIOIDS AND COMPOSITIONS PRODUCED THEREBY
    Publication number: 20100183687
    Abstract: The present invention provides compositions comprising particles comprising a poorly soluble opioid drug and a stabilizer, wherein the particles have an average diameter of less than about 10,000 nm. Methods of making the compositions and their use as pharmaceutical compositions for treating disorders such as pain are also described.
    Type: Application
    Filed: January 22, 2010
    Publication date: July 22, 2010
    Inventors: D. Phillip Cox, James D. Talton
  • METHODS FOR ONE-POT N-DEMETHYLATION/N-ACYLATION OF MORPHINE AND TROPANE ALKALOIDS
    Publication number: 20090005565
    Abstract: The present invention provides a method for the N-demethylation and/or N-acylation of an N-methylated heterocycle such as morphine alkaloids or tropane alkaloids. The method comprises reacting the heterocycle with an acylating agent in the presence of a metal catalyst.
    Type: Application
    Filed: June 29, 2007
    Publication date: January 1, 2009
    Inventors: Robert James Carroll, Hannes Leisch, Tomas Hudlicky, D. Phillip Cox
  • Process For Preparing Oxycodone Having Reduced Levels Of 14-Hydroxycodeinone
    Publication number: 20080139814
    Abstract: The present invention is directed to processes for preparing oxycodone base and oxycodone hydrochloride compositions having less than 10 ppm of 14-hydroxycodeinone.
    Type: Application
    Filed: December 4, 2007
    Publication date: June 12, 2008
    Inventors: D. Phillip Cox, Yong Zhang, Wen-Chun Zhang, Karen E. James
  • Process for Reducing Impurities in Oxycodone Base
    Publication number: 20080132703
    Abstract: The present invention is directed to a process for using n-butanol to prepare an oxycodone base compositions having reduced levels of impurities such as 14-hydroxycodeinone and DHDHC.
    Type: Application
    Filed: December 4, 2007
    Publication date: June 5, 2008
    Inventors: D. Phillip Cox, Yong Zhang