Patents by Inventor D. Roxanne Duan

D. Roxanne Duan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 52 human secreted proteins
    Publication number: 20020064818
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: February 22, 2001
    Publication date: May 30, 2002
    Inventors: Jian Ni, Kevin P. Baker, Charles E. Birse, Michele Fiscella, George A. Komatsoulis, Craig A. Rosen, Daniel R. Soppet, Paul E. Young, Reinhard Ebner, D. Roxanne Duan, Henrik S. Olsen, David W. LaFleur, Paul A. Moore, Yanggu Shi, Ping Wei, Kimberly A. Florence
  • ELL2, a new member of an ELL family of RNA polymerase II elongation factors
    Patent number: 6379923
    Abstract: ELL2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ELL2 polypeptides and polynucleotides in the design of protocols for the treatment of neoplastic disorders, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: July 29, 1999
    Date of Patent: April 30, 2002
    Assignees: Human Genome Sciences, Inc., Oklahoma Medical Research Foundation
    Inventors: D. Roxanne Duan, Ali Shilatifard, Joan W. Conaway, Ronald C. Conaway
  • Nucleic acid molecules encoding Follistatin-3
    Patent number: 6372454
    Abstract: The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: April 16, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: D. Roxanne Duan, Steven M. Ruben
  • NUCLEIC ACID ENCODING FOLLISTATIN-3
    Publication number: 20010014464
    Abstract: The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
    Type: Application
    Filed: August 27, 1998
    Publication date: August 16, 2001
    Inventors: D. ROXANNE DUAN, STEVEN M. RUBEN
  • Keratinocyte growth factor-2
    Patent number: 6077692
    Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: June 20, 2000
    Assignee: Human Genome Sciences, Inc.
    Inventors: Steven M. Ruben, Pablo Jimenez, D. Roxanne Duan, Mark A. Rampy, Donna Mendrick, Jun Zhang, Jian Ni, Paul A. Moore, Timothy A. Coleman, Joachim R. Gruber, Patrick J. Dillon, Reiner L. Gentz
  • ELL2, a new member of an ELL family of RNA polymerase II elongation factors
    Patent number: 6008018
    Abstract: ELL2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ELL2 polypeptides and polynucleotides in the design of protocols for the treatment of neoplastic disorders, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: December 28, 1999
    Assignees: Human Genome Sciences, Inc., Oklahoma Medical Research Foundation
    Inventors: D. Roxanne Duan, Ali Shilatifard, Joan W. Conaway, Ronald C. Conway