Patents by Inventor D. T. Jones
D. T. Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11428574Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.Type: GrantFiled: December 19, 2017Date of Patent: August 30, 2022Assignee: NUEON INC.Inventors: Robert G. Messerschmidt, Howland D. T. Jones
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Patent number: 11060967Abstract: Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time.Type: GrantFiled: June 12, 2017Date of Patent: July 13, 2021Assignee: NUEON INC.Inventors: Robert G. Messerschmidt, Howland D. T. Jones
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Patent number: 10760965Abstract: Described herein are methods and apparatus for spectroscopic analysis of samples. In many embodiments, an apparatus for providing spectroscopic analysis of a sample comprises a sample holder. For example, the sample holder may comprise a consumable single use sample holder that can be readily coupled to and removed from a measurement apparatus such as a spectrometer. The sample holder may comprise a measurement surface configured to receive the sample during measurement, wherein the measurement surface may comprise a porous mesh. The porous mesh can receive the sample to optimally configure the sample for spectroscopic measurement, as described in further detail herein.Type: GrantFiled: September 20, 2018Date of Patent: September 1, 2020Assignee: NUEON INC.Inventors: Robert G. Messerschmidt, Howland D. T. Jones
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Patent number: 9797836Abstract: A hyperspectral imaging flow cytometer can acquire high-resolution hyperspectral images of particles, such as biological cells, flowing through a microfluidic system. The hyperspectral imaging flow cytometer can provide detailed spatial maps of multiple emitting species, cell morphology information, and state of health. An optimized system can image about 20 cells per second. The hyperspectral imaging flow cytometer enables many thousands of cells to be characterized in a single session.Type: GrantFiled: February 18, 2013Date of Patent: October 24, 2017Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Michael B. Sinclair, Howland D. T. Jones
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Patent number: 8557031Abstract: This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.Type: GrantFiled: January 7, 2011Date of Patent: October 15, 2013Assignee: Sandia CorporationInventors: Michael Hibbs, Susan J. Altman, Howland D. T. Jones, Paul B. Savage
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Patent number: 8530002Abstract: This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.Type: GrantFiled: January 7, 2011Date of Patent: September 10, 2013Assignee: Sandia CorporationInventors: Michael Hibbs, Susan J. Altman, Howland D. T. Jones, Paul B. Savage
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Patent number: 8529681Abstract: This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.Type: GrantFiled: January 7, 2011Date of Patent: September 10, 2013Assignee: Sandia CorporationInventors: Michael Hibbs, Susan J. Altman, Howland D. T. Jones, Paul B. Savage
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Patent number: 7202091Abstract: Systems and methods for establishing and/or maintaining the accuracy of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to reduce the effect of instrument or environment variation on the measurement capability of the model. The optically similar reference can be a gel composition having scattering particles suspended therein. The reference gel can be directly applied to a spectroscopic instrument sampler, or can be in a container specifically designed for optimal coupling to a spectroscopic instrument.Type: GrantFiled: October 28, 2002Date of Patent: April 10, 2007Assignee: InLight Solutions, Inc.Inventors: Howland D. T. Jones, David J. Nunez, Stephen J. Vanslyke, Robert D. Johnson, Edward L. Hull
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Publication number: 20040241736Abstract: A method and apparatus for determining an attribute of a sample from a spectrum of the sample. The invention comprises samplers and methods of sampling that provide controlled optical pathlengths through the sample, increasing the accuracy of the attribute determinations. The invention is applicable, for example, in determining analyte concentrations in biological samples, such as concentrations of analytes such as glucose in human blood.Type: ApplicationFiled: May 21, 2004Publication date: December 2, 2004Inventors: Shonn P. Hendee, Howland D. T. Jones, Dashiell A. Birnkrant, Robert D. Johnson, Russell E. Abbink, Robert G. Messerschmidt
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Publication number: 20040082070Abstract: Systems and methods for establishing and/or maintaining the accuracy of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to reduce the effect of instrument or environment variation on the measurement capability of the model. The optically similar reference can be a gel composition having scattering particles suspended therein. The reference gel can be directly applied to a spectroscopic instrument sampler, or can be in a container specifically designed for optimal coupling to a spectroscopic instrument.Type: ApplicationFiled: October 28, 2002Publication date: April 29, 2004Inventors: Howland D. T. Jones, David J. Nunez, Stephen J. Vanslyke, Robert D. Johnson, Edward L. Hull
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Publication number: 20040027659Abstract: A sample holder comprising a material that is functionally transparent to wavelengths of light that are important to visual analysis of the sample, and to wavelengths of light that are important to spectroscopic analysis of the sample. Embodiments of the invention are amenable to total internal reflection of light useful in spectroscopic analysis. Specific materials and configurations are described. Methods and apparatuses using such sample holders for measurement of sample properties, including cancer screening of cervical samples, are described.Type: ApplicationFiled: July 28, 2003Publication date: February 12, 2004Inventors: Robert G. Messerschmidt, Howland D. T. Jones, Robert D. Johnson, V. Gerald Grafe
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Patent number: 5617569Abstract: A method and system in an object-oriented environment for determining the offset of a data member of a derived class when the derived class has a virtually inherited base class and the data member is defined in the base class. In a preferred embodiment, the base class has a data structure and a class address. The base class data structure has the data member located at a data member offset from the base class address. The derived class has a data structure and a class address. The derived class data structure includes an occurrence of the base class data structure. The occurrence of the base class data structure is located at a base class offset from the derived class address.Type: GrantFiled: April 10, 1995Date of Patent: April 1, 1997Assignee: Microsoft CorporationInventors: Jan Gray, D. T. Jones, Martin O'Riordan
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Patent number: 5596992Abstract: Multivariate classification techniques are applied to spectra from cell and tissue samples irradiated with infrared radiation to determine if the samples are normal or abnormal (cancerous). Mid and near infrared radiation can be used for in vivo and in vitro classifications using at least different wavelengths.Type: GrantFiled: June 30, 1993Date of Patent: January 28, 1997Assignee: Sandia CorporationInventors: David M. Haaland, Howland D. T. Jones, Edward V. Thomas
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Patent number: 5432936Abstract: A method and system in an object-oriented environment for determining the offset of a data member of a derived class when the derived class has a virtually inherited base class and the data member is defined in the base class. In a preferred embodiment, the base class has a data structure and a class address. The base class data structure has the data member located at a data member offset from the base class address. The derived class has a data structure and a class address. The derived class data structure includes an occurrence of the base class data structure. The occurrence of the base class data structure is located at a base class offset from the derived class address.Type: GrantFiled: April 9, 1992Date of Patent: July 11, 1995Assignee: Microsoft CorporationInventors: Jan Gray, D. T. Jones, Martin O'Riordan
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Patent number: 5015346Abstract: An electrochemical method for defect delineation in thin-film SOI or SOS wafers in which a surface of a silicon wafer is electrically connected so as to control the voltage of the surface within a specified range, the silicon wafer is then contacted with an electrolyte, and, after removing the electrolyte, defects and metal contamination in the silicon wafer are identified.Type: GrantFiled: April 10, 1990Date of Patent: May 14, 1991Assignee: United States Department of EnergyInventors: Terry R. Guilinger, Howland D. T. Jones, Michael J. Kelly, John W. Medernach, Joel O. Stevenson, Sylvia S. Tsao