Patents by Inventor D. Thomas Rutkowski

D. Thomas Rutkowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conformational and topological protein regulation
    Patent number: 7041462
    Abstract: Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: May 9, 2006
    Assignee: Regents of the University of California
    Inventors: Vishwanath R. Lingappa, D. Thomas Rutkowski, Ramanujan S. Hegde
  • Conformational and topological protein regulation
    Patent number: 6821742
    Abstract: Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: November 23, 2004
    Assignee: Regents of the University of California
    Inventors: Vishwanath R. Lingappa, D. Thomas Rutkowski, Ramanujan S. Hegde
  • Conformational and topological protein regulation
    Publication number: 20020137915
    Abstract: Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.
    Type: Application
    Filed: December 15, 2000
    Publication date: September 26, 2002
    Inventors: Vishwanath R. Lingappa, D. Thomas Rutkowski, Ramanugan S. Hegde