Abstract: A method for continuously removing a particular type of gas molecules (“gas molecules”) from a gas stream includes selecting a liquid having an affinity for the gas molecules to be removed, and providing the selected liquid to each of a first and second mat, each mat formed from a plurality of fibers having the ability to retain the selected liquid within longitudinally extending channels having longitudinally extending openings against moving into the space between the individual fibers, the mats in fluid communication therebetween with the selected liquid. The method includes directing the gas stream through a portion of the first mat into contact with the selected liquid along the longitudinally extending openings whereby the selected liquid absorbs the gas molecules, and directing a second gas through a portion of the second mat so that the gas molecules, absorbed by and disbursed throughout the selected liquid, are stripped and carried away.

Abstract: A drug delivery device has a housing with an adhesive pad associated with the lower surface of the housing and configured to removably attach to a human body surface. A drug container is positioned within the housing and includes an outlet, with a needle fluidically connected to the container and configured to define at least a portion of a fluid flow path between the container and the human body surface. A controller is configured to execute a drug delivery routine. The drug delivery device includes a buzzer and an indicator light for providing indications. The drug delivery device also includes a plunger within the drug container. A method of delivering pegfilgrastim from a drug delivery device includes providing an audible indication that the drug delivery device is activated, executing a drug delivery routine, and providing a first and second indication during the drug delivery procedure.

Abstract: A method of screening a composition for cardiotoxicity comprising contacting the composition with cardiomyocytes that have increased fatty acid oxidation and/or diminished glucose oxidation. The cardiomyocytes are preferably prepared by overexpression of COX7A1. The cardiomyocytes are preferably provided in a micropatterned co-culture to provide a mature functional hPSC-CM cardiotoxicity model.

Abstract: Compositions and methods are disclosed for targeting the clustered protocadherins for therapeutic effect. More specifically, compositions and methods are disclosed to modify select isoforms in the ?, ?, and ? cluster to promote tissue regeneration or to target and reduce tumor burden in diverse cancer types. The methods have application in veterinary and human medicine.

Abstract: In one aspect, the disclosure relates to engineered microvessels including a microchannel formed in a hydrogel material; and a medial layer including a plurality of mural cells such as, for example, smooth muscle cells and/or pericytes; wherein each one of the plurality of mural cells is in contact with a wall of the microchannel; and wherein the plurality of mural cells are helically aligned at an angle relative to a lengthwise axis of the microchannel. The microvessels have narrow diameters consistent with resistance microvessels such as small resistance arteries and arterioles and tunable stiffness resulting from degree of crosslinking within the hydrogel material. Also disclosed are methods of making the microvessels, microvessel networks including the microvessels, and engineered organs and tissues including the microvessels. Furthermore, disclosed is a method for inducing vasoconstriction and vasodilation in the microvessels, networks, and engineered organs and tissues.

Abstract: A drug delivery assembly is used for delivering a medicament to a patient. The assembly includes a housing having upper and lower surfaces and a sidewall, with an actuator associated with the sidewall. An adhesive pad, configured to attach to a human body surface, is associated with the lower surface of the housing. The assembly also includes a drug reservoir positioned within the housing, associated with a needle movably associated with the drug reservoir. The actuator is moved from a first position to a second position to deploy the needle, with movement of the actuator being generally perpendicular to movement of the needle.

Abstract: Aspects of the present invention include compositions and methods for discovering novel compositions and applying said compositions in treating medical conditions including aging, degenerative disease, and cancer through the modulation of molecular pathways regulating the regenerative and nonregenerative phenotypes of mammalian cells by means of globally or segmentally altering the embryonic-fetal and prenatal/postnatal transitional states of mammalian cells.

Abstract: A drug delivery device and cartridge wherein the cartridge includes a movable use indicator that indicates whether the cartridge has been opened and/or used.

Abstract: Embodiments disclosed herein are fluid collection devices, and related systems and methods of use and manufacture. The fluid collection device may include a fluid impermeable barrier, a porous material, and a conduit. The fluid impermeable barrier may have an elongated shape with a proximal region and a distal region, and including a first impermeable layer and a second impermeable layer opposite to the first impermeable layer and defining an opening. The first impermeable layer and the second impermeable layer at least partially defining a chamber therebetween, the chamber including a pocket portion that extends distally from the opening between the first impermeable layer and the second impermeable layer. The porous material extends across the opening and is positioned in the pocket portion of the chamber. The porous material is configured to space the first impermeable layer from the second impermeable layer in the pocket portion of the chamber.

Abstract: Methods are provided for the ex vivo reprogramming of adult mammalian cells, wherein the genes used in reprogramming the adult cells are expressed with heterologous promoters that increase expression of associated genes while the cell is in a fetal or adult non-regenerative state, but down-regulated the expression of genes once cells reach a regenerative state and before the cells are reprogrammed to pluripotency. In addition, heterologous promoters uniquely expressing genes when cells are in an embryonic (pre-fetal state) are used to increase expression of toxic gene products in cancer cells.

Abstract: Aspects of the present invention include compositions and methods for discovering novel compositions and applying said compositions in treating medical conditions including aging, degenerative disease, and cancer through the modulation of molecular pathways regulating regeneration and senolysis by means of altering the embryonic-fetal and prenatal/postnatal transitional states of mammalian cells.

Abstract: A drug delivery device has a housing with an adhesive pad associated with the lower surface of the housing and configured to removably attach to a human body surface. A drug reservoir is positioned within the housing and includes an outlet with a valve, with a needle fluidically connected to the reservoir and configured to define at least a portion of a fluid flow path between the reservoir and the human body surface. A controller is configured to control the components of the drug delivery device to execute a drug delivery routine. The drug delivery device also includes pressurized fluid positioned to apply a force to the reservoir. The controller moves the valve from a closed condition to an open condition during a drug delivery routine to allow the pressurized fluid to deform the reservoir or move a plunger to convey the drug out of the reservoir via the outlet.

Abstract: A drug dispensing system with replaceable cartridges wherein the system indicates whether the cartridge is suitable for use.

Abstract: This invention relates to a printed textile substrate, such as a floorcovering article, and a process for making a printed textile substrate. This invention provides the process and steps to print color patterns in-register with physical patterns, such as varying yarn pile heights, yarn luster, yarn color, and the like. This process provides many unique aesthetics on a textile substrate that cannot be created another way.

Abstract: This invention relates to a printed textile substrate, such as a floorcovering article, and a process for making a printed textile substrate. This invention provides the process and steps to print color patterns in-register with physical patterns, such as varying yarn pile heights, yarn luster, yarn color, and the like. This process provides many unique aesthetics on a textile substrate that cannot be created another way.

Abstract: This invention relates to a printed textile substrate, such as a floorcovering article, and a process for making a printed textile substrate. This invention provides the process and steps to print color patterns in-register with physical patterns, such as varying yarn pile heights, yarn luster, yarn color, and the like. This process provides many unique aesthetics on a textile substrate that cannot be created another way.

Abstract: This invention relates to a printed textile substrate, such as a floorcovering article, and a process for making a printed textile substrate. This invention provides the process and steps to print color patterns in-register with physical patterns, such as varying yarn pile heights, yarn luster, yarn color, and the like. This process provides many unique aesthetics on a textile substrate that cannot be created another way.

Abstract: This invention relates to a printed textile substrate, such as a floorcovering article, and a process for making a printed textile substrate. This invention provides the process and steps to print color patterns in-register with physical patterns, such as varying yarn pile heights, yarn luster, yarn color, and the like. This process provides many unique aesthetics on a textile substrate that cannot be created another way.

Abstract: A system includes a plurality of photovoltaic modules installed on a roof deck in an array. Each of the photovoltaic modules includes a wire cover bracket substantially aligned with the wire cover bracket of an adjacent another one of the photovoltaic modules. At least one cover is removably attached to at least one of the wire cover brackets. The cover includes a top portion, a first side portion extending from a first side of the top portion, and a second side portion extending from a second side of the top portion opposite the first side. The top portion of the at least one cover is configured to divert water from entering the wire cover bracket from above the at least one cover. The first and second side portions are configured to divert water from entering the wire cover bracket from a lateral direction relative to the wire cover bracket.

Abstract: A medicament delivery device and method of use thereof. The device includes a sensor module and an injector module. The injector module is adapted to (i) be coupled to the sensor module during injection of a cannula and a needle into subcutaneous tissue and during delivery of the medicament and (ii) be removed from the sensor module after the delivery of the medicament.