Abstract: The present invention is related to the development of novel compounds and methods for the treatment and/or prevention of malaria. The compounds prevent the formation by the malaria parasite of the plasmodium surface anion channel (PSAC) on the surface of the host cell. The compounds and methods described herein are effective against infection by a wide variety of Plasmodia strains known as the causative agent of malaria.

Abstract: Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Abstract: Various embodiments of the systems, methods, and devices are provided for controlled operation of an intravascular lithotripsy system for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing electrical energy to generate an electrical arc between a set of spaced-apart electrodes disposed within a fluid-filled member configured to contain a conductive fluid.

Abstract: Various embodiments of the systems, methods, and devices are provided for controlled operation of an intravascular lithotripsy system for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing electrical energy to generate an electrical arc between a set of spaced-apart electrodes disposed within fluid-fillable member are disclosed.

Abstract: An evaporative emission control canister system comprises an initial adsorbent volume having an effective incremental adsorption capacity at 25° C. of greater than 35 grams n-butane/L between vapor concentration of 5 vol % and 50 vol % n-butane, and at least one subsequent adsorbent volume having an effective incremental adsorption capacity at 25° C. of less than 35 grams n-butane/L between vapor concentration of 5 vol % and 50 vol % n-butane, an effective butane working capacity (BWC) of less than 3 g/dL, and a g-total BWC of between 2 grams and 6 grams. The evaporative emission control canister system has a two-day diurnal breathing loss (DBL) emissions of no more than 20 mg at no more than 210 liters of purge applied after the 40 g/hr butane loading step.

Abstract: Various embodiments of the systems, methods, and devices are provided for controlled operation of an intravascular lithotripsy (“IVL”) system for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing and/or assessing the electrical energy needed to generate an electrical arc between a set of spaced-apart electrodes disposed within a fluid-fillable member.

Abstract: A valve assembly includes an inlet to receive a fluid into the valve assembly, an outlet to discharge the fluid from the valve assembly and a service stop coupled to the inlet or the outlet. The service stop can rotate relative to the inlet or the outlet to control a flow of the fluid through the inlet or the outlet. The service stop can include a first tool interface to receive a first hand tool and transfer a first torque from the first hand tool to the service stop to facilitate rotating the service stop using the first hand tool. The service stop can include a second tool interface to receive a second hand tool different from the first hand tool and configured to transfer a second torque from the second hand tool to the service stop to facilitate rotating the service stop using the second hand tool.

Abstract: The present disclosure describes a module for a telecommunications pole. The module may include a main base plate configured such that telecommunications equipment can be mounted thereto, a top frame member and a bottom frame member coupled to opposing ends of the main base plate and extending outwardly from, and generally perpendicularly to, the main base plate; and a plurality of side frame members coupled to the top and bottom frame members, each side frame member extending collinearly with the main base plate. The top, bottom and side frame members each include a plurality of recesses and protrusions configured and/or positioned such that the top, bottom, and side frame members may be aligned and assembled within the telecommunications pole. Module assemblies and methods of assembling the modules are also described herein.

Abstract: An exhaust gas heater system for an exhaust system of an internal combustion engine includes a housing and a heating element. The housing includes an outer peripheral wall disposed about a central axis and defining an interior hollow space configured to receive exhaust gas from an exhaust pipe of the exhaust system such that the exhaust gas flows through the interior hollow space. The heating element is positioned within the hollow space and including a first end and a second end. The heating element forms a zig-zag shape extending in a radial direction relative to the central axis.

Abstract: The present disclosure generally relates to context-specific user interfaces. In some embodiments, methods are provided for displaying a watch user interface including a clock face and a user interface element at least partially surrounding the clock face. In some embodiments, methods are further provided for receiving a request to add a respective complication to a respective location on the clock face and, in response to receiving the request: in accordance with a determination that the respective complication is a first complication, displaying the first complication in the respective location and replacing at least a portion of the user interface element with content associated with the first complication; and in accordance with a determination that the respective complication is a second complication, displaying the second complication in the respective location without replacing the portion of the user interface element with content associated with the second complication.

Abstract: An evaporative emission control canister system comprises an initial adsorbent volume having an effective incremental adsorption capacity at 25° C. of greater than 35 grams n-butane/L between vapor concentration of 5 vol % and 50 vol % n-butane, and at least one subsequent adsorbent volume having an effective incremental adsorption capacity at 25° C. of less than 35 grams n-butane/L between vapor concentration of 5 vol % and 50 vol % n-butane, an effective butane working capacity (BWC) of less than 3 g/dL, and a g-total BWC of between 2 grams and 6 grams. The evaporative emission control canister system has a two-day diurnal breathing loss (DBL) emissions of no more than 20 mg at no more than 210 liters of purge applied after the 40 g/hr butane loading step.

Abstract: An implantable medical lead may include an electrode at a distal portion of the lead that is configured to monitor or provide therapy to a target site. The lead may include a visible indicator that is visible to the naked eye of a clinician at a medial portion of the lead that is configured to indicate when the electrodes of the lead are longitudinally and radially aligned properly to monitor or treat the target site. A clinician may insert the lead into the patient using an introducer sheath inserted to a predetermined depth into the patient and subsequently aligning the distal portion of the lead by orienting the indicator at an entry port of the introducer sheath.

Abstract: An encapsulation block for a digital signal processing (DSP) block. The encapsulation block includes DSP block having an input terminal, an output terminal, and an input clock. The encapsulation block also includes pacing control network operatively connected with the input terminal, the output terminal, and the input clock of the DSP block. The input terminal of the DSP block is configured to receive a samples-in data stream inputted at a predefined clock period defined by the input clock. The output terminal of the DSP block is configured to receive a samples-out data stream outputted at a predefined paced parameter. The pacing control network is configured to control data flow at the samples-in data stream and the samples-out data stream independently of the DSP block.

Abstract: A tow hook assembly coupled to the cross member of a vehicle. The tow hook assembly includes a housing, a tow hook, and a biasing member. The tow hook is pivotally coupled to the housing and positionable between an extended position and a retracted position. The biasing member is coupled to the tow hook and the housing to bias the tow hook towards the extended position. The tow hook is configured to pivot from the extended position towards the retracted position upon application of a force exceeding a threshold applied to the tow hook.

Abstract: A method for determining parallel lift feedforward control of a bucket of a work vehicle is provided. The method includes calculating a current stroke length of a bucket cylinder at a current moment based on a current bell crank plate angle and a current boom angle. The method includes predicting a future boom angle after a certain number of steps. The method further includes calculating a required bell crank plate angle from a learned cutting edge angle and the future boom angle. The method even further includes calculating a future stroke length of the bucket cylinder after the certain number of steps. The method yet further includes calculating an average speed command for bucket control based on the current stroke length and the future stroke length of the bucket cylinder. The method still further includes calculating a bucket cylinder control command based on the average speed command for bucket control.

Abstract: A multilayer composite containing a polymeric membrane, a hot-melt adhesive layer, and a release liner, wherein the hot-melt adhesive layer comprises a thermally curable pressure-sensitive adhesive. The invention further relates to a process to make the composite and to use the composite as a roofing material, label, tape, Graphics and Medical applications.

Abstract: A detector for detecting the removal and/or insertion of a weapon out of and/or into a holster. The detector may transmit a message each time the weapon is removed from the holster. A recording system may receive the message and determine whether or not it will begin recording the data it captures. A detector may detect the change in a magnitude of an inductance and/or an impedance of a circuit to detect insertion and removal of the weapon into and out of the holster. The holster is configured to couple to the detector to position the detector to detect insertion and removal of the weapon. An adhesive tape may couple a detector to a holster.

Abstract: The present disclosure generally relates to methods for sending event notifications. In some examples, a controller periodically sends messages concerning a status of an event corresponding to the controller. In some examples, at a first time while periodically sending the messages and in accordance with a determination that the status of the event has changed, the controller sends a message concerning data other than the status of the event. In some examples, at the first time while periodically sending the messages and in accordance with a determination that the status of the event has not changed, the controller continues to periodically send the messages without sending the message concerning data other than the status of the event.

Abstract: A method of manufacturing an interface for a body part using an additive manufacturing process is described. The method obtaining a digital model of the body part and modifying the digital model to create a plurality of compression areas. The compression areas are spaced circumferentially around a long axis of the digital model to create a compression pattern. The compression pattern is sized and dimensioned to compress soft tissue of the body part against the skeletal structure such that motion of the skeletal structure towards a wall of the interface is reduced.

Abstract: A system and method including receiving a digital representation of a road that includes one or more lane representations; defining a factor graph including variable nodes and constraint nodes that encode lane boundary constraints for the lane map; translating the factor graph into a nonlinear optimization problem for altitudes of the lane map; generating a solution to the optimization problem; and generating a corrected lane map with an optimized altitude for the road based on the generated solution.