Abstract: An implantable medical device is provided. The device comprises a drug release layer, wherein the drug release layer contains particles dispersed within a polymer matrix. The lipid particles include a carrier component that contains a carrier (e.g., peptide, protein, carbohydrate, lipid, polymer, etc.) and encapsulates a nucleic acid, wherein the polymer matrix includes an ethylene vinyl acetate copolymer. The ratio of the melting temperature of the ethylene vinyl acetate copolymer to the melting temperature of the carrier is about 2° C./° C. or less.

Abstract: Described are methods, systems, devices for facilitation of intraluminal medical procedures within the neurovasculature. A catheter advancement device includes a flexible elongate body having a proximal portion coupled to a proximal end region of the flexible elongate body and extending proximally to a proximal-most end of the catheter advancement element. A hardness of the flexible elongate body transitions proximally towards increasingly harder materials up to the proximal portion forming a first plurality of material transitions. At least a portion of the flexible elongate body is formed of a plurality of layers including a reinforcement layer. An outer diameter of the flexible elongate body is sized to be positioned coaxially within a lumen of a catheter such that a distal tip portion of the flexible elongate body extends distally beyond a distal end of the catheter to aid in delivery of the catheter to an intracranial vessel.

Abstract: A scroll device has a fixed scroll, and orbiting scroll, and at least one cooling chamber configured to receive coolant to cool the fixed scroll or the orbiting scroll. A flexible conduit that curves around an orbital axis of the orbiting scroll may transfer coolant into or out of the at least one cooling chamber. The scroll device may have a motor with a motor jacket configured to receive coolant for cooling the motor. One or more involutes of the scroll device may comprise a wall coated or plated with a solid abrasion-resistant lubricant.

Abstract: A tray (100) for accommodating a coiled medical device, such as a catheter assembly (700), includes a first compartment (101), a second compartment (102), and a third compartment (103). The catheter assembly (700) and devices associated with a catheterization procedure, such as syringes (701,702) containing sterile water and lubricating jelly and a specimen container (703) can be disposed within the tray. A first barrier (105) and second barrier (106) separate the compartments. The barriers can have openings (121,122) therein to accommodate large syringes or to enable the first compartment (101) to be used as a lubricant applicator for the catheter. The first compartment (101) can include a stair-stepped contour (115) such that the syringes are held at different depths to facilitate ease of use. The various devices can be disposed within the tray (100) in accordance with their order of use in the catheterization procedure.

Abstract: Color and exposure matching for systems, such as a videoconferencing endpoint, that have overlapping camera fields of view. The geometric relationships between the overlapping cameras are used to determine correction processing. For each camera, histograms are developed for the overlapping cameras. A dynamic threshold is determined for each histogram. Using the dynamic threshold, peak detection is performed on each histogram. Using the geometric relationships, expected histogram relationships are determined. The actual histogram relationships are compared to the expected relationships, with further processing based on the correctness of the comparison. In some of the cases of further processing, peaks of the histograms are compared to find matching and non-matching peaks. Various ratios of pixels in the various peaks are used to determine needed changes to respective cameras.

Abstract: Controlling contents of interfaces may include receiving multiple interfaces presented on a display screen. The multiple interfaces may include at least one primary task interface and each of the multiple interfaces may present at least one content item. A user engagement level with respect to content items presented via the multiple interfaces may be estimated. A degree of user effectiveness with respect to progression toward completing a primary task presented via the primary task interface may be determined. A content item may be selected from the multiple interfaces based on the user engagement level and the degree of user effectiveness. A presentation of the selected content item may be made in a controlled manner on an unused portion of at least one of the multiple interfaces.

Abstract: A method for sensor event coverage and energy conservation includes receiving device sensor data for a plurality of sensors in a sensor network. The method further includes identifying one or more anomalies in the device sensor data that indicate one or more sensors from the plurality of sensors were acquiring data during an event for a specific point in time and identifying movement patterns for the plurality of sensors based on the one or more anomalies. The method further includes responsive to updating base engagement profiles for the plurality of sensors based on the one or more anomalies and the movement patterns, activating based on the updated base engagement profiled, a first sensor from the plurality of sensors.

Abstract: A process of making a fuel product from a non-combustible high protein organic material such as a biological by-product or waste material. The moisture content of the high protein organic material is mechanically reduced and dried to reduce the moisture content to less than ten percent (10%). The high protein organic material is pulverized to a particle size of less than about 2 mm. The high protein organic waste material is fed into a combustion chamber and separated during combustion such as by spraying of the high protein organic waste material within the combustion chamber. Temperature and nitrogenous hydrocarbon combustion reactions within the combustion chamber are also controlled by injection of steam within the combustion chamber. The concentration of protein thermal decomposition by-products, the temperature and/or pressure within the combustion chamber is also controlled to degrade hazardous polyfluoro compounds into less hazardous compounds.

Abstract: A blockchain of transactions may be referenced for various purposes and may be later accessed by interested parties for ledger verification. One example method of operation may comprise one or more of identifying shipment locations for a product shipment, storing the shipment locations in a local blockchain, transmitting the shipment locations to a remote blockchain, comparing the shipment locations of the remote blockchain with the shipment locations stored in the local blockchain, and verifying the shipment locations of the remote blockchain are consistent with the shipment locations stored in the local blockchain.

Abstract: A computer-implemented method for determining focus of a user is provided. User input is received. An intention image of a scene including a plurality of interactive objects is generated. The intention image includes pixels encoded with intention values determined based on the user input. An intention value indicates a likelihood that the user intends to focus on the pixel. An intention score is determined for each interactive object based on the intention values of pixels that correspond to the interactive object. An interactive object of the plurality of interactive objects is determined to be a focused object that has the user's focus based on the intention scores of the plurality of interactive objects.

Abstract: A computer device is provided that includes a display device, and a sensor system configured to be mounted adjacent to a user's head and to measure an electrical potential near one or more electrodes of the sensor system. The computer device further includes a processor configured to present a periodic motion-based visual stimulus having a changing motion that is frequency-modulated for a target frequency or code-modulated for a target code, detect changes in the electrical potential via the one or more electrodes, identify a corresponding visual evoked potential feature in the detected changes in electrical potential that corresponds to the periodic motion-based visual stimulus, and recognize a user input to the computing device based on identifying the corresponding visual evoked potential feature.

Abstract: Described are methods, systems, devices for facilitation of intraluminal medical procedures within the neurovasculature. A catheter advancement device includes a flexible elongate body having a proximal portion coupled to a proximal end region of the flexible elongate body and extending proximally to a proximal-most end of the catheter advancement element. A hardness of the flexible elongate body transitions proximally towards increasingly harder materials up to the proximal portion forming a first plurality of material transitions. At least a portion of the flexible elongate body is formed of a plurality of layers including a reinforcement layer. An outer diameter of the flexible elongate body is sized to be positioned coaxially within a lumen of a catheter such that a distal tip portion of the flexible elongate body extends distally beyond a distal end of the catheter to aid in delivery of the catheter to an intracranial vessel.

Abstract: A method of performing a medical procedure in a cerebral vessel including advancing a guide sheath into an internal carotid artery; advancing a catheter within a lumen of the guide sheath until a distal end of the catheter is adjacent to an embolus in a cerebral vessel; activating a vacuum source to create a vacuum in a lumen of the catheter; and cyclically controlling the vacuum applied with a valve. The vacuum is cyclically controlled by opening the valve for a first time period, closing the valve for a second time period longer than the first time period, opening the valve for a third time period shorter than the first time period, then closing the valve for a fourth time period greater than the first time period, and repeating for at least 40 cycles.

Abstract: An intravascular access system for facilitation of intraluminal medical procedures within the neurovasculature through an access sheath. The system includes an aspiration or support catheter having a flexible, distal luminal portion having an inner diameter defining a lumen extending between a proximal opening at a proximal end of the luminal portion and a distal opening at a distal end of the luminal portion. The catheter has a rigid spine coupled to at least the proximal end of the luminal portion and extending proximally therefrom. The system includes a dilator having a flexible, distal dilator portion sized to be received within the lumen of the luminal portion. Associated systems, devices, and methods of use are also described.

Abstract: An intravascular access system for facilitation of intraluminal medical procedures within the neurovasculature through an access sheath. The system includes an aspiration or support catheter having a flexible, distal luminal portion having an inner diameter defining a lumen extending between a proximal opening at a proximal end of the luminal portion and a distal opening at a distal end of the luminal portion. The catheter has a rigid spine coupled to at least the proximal end of the luminal portion and extending proximally therefrom. The system includes a dilator having a flexible, distal dilator portion sized to be received within the lumen of the luminal portion. Associated systems, devices, and methods of use are also described.

Abstract: A saline feed stream flows into a liquid-liquid extraction system; and a volatile organic solvent flows through a main compressor. The compressed volatile organic solvent then flows through a solvent regenerator, which can be a heat exchanger or a combination of a vaporization device and a condenser, to cool the volatile organic solvent. The cooled volatile organic solvent in liquid phase then flows into the liquid-liquid extraction system, where the saline feed stream contacts the volatile organic solvent to selectively extract water from the saline feed stream into the volatile organic solvent, producing a concentrated brine and an organic-rich mixture of water and the volatile organic solvent. The organic-rich mixture flows from the liquid-liquid extraction system into the solvent regenerator, where the organic-rich mixture is heated to produce an organic-rich vapor and desalinated water; and the organic-rich vapor is recycled as volatile organic solvent back into the liquid-liquid extraction system.

Abstract: A prime mover for a lightweight vehicle comprising an internal combustion engine, a starter motor integrally integrated with the internal combustion engine, and a housing for the prime mover. The prime mover additionally comprises a Hall Effect sensor and an prime mover control module structured and operable to communicate with the Hall Effect sensor, determine when operation of the internal combustion engine should cease, and upon the determination that operation of the internal combustion engine should cease, utilize the communication from the Hall Effect sensor to stop the internal combustion engine such that a piston of the internal combustion engine is positioned at between 15° and 25° after bottom-dead-center.

Abstract: Described are methods, systems, devices for facilitation of intraluminal medical procedures within the neurovasculature. A catheter advancement device includes a flexible elongate body having a proximal portion coupled to a proximal end region of the flexible elongate body and extending proximally to a proximal-most end of the catheter advancement element. A hardness of the flexible elongate body transitions proximally towards increasingly harder materials up to the proximal portion forming a first plurality of material transitions. At least a portion of the flexible elongate body is formed of a plurality of layers including a reinforcement layer. An outer diameter of the flexible elongate body is sized to be positioned coaxially within a lumen of a catheter such that a distal tip portion of the flexible elongate body extends distally beyond a distal end of the catheter to aid in delivery of the catheter to an intracranial vessel.

Abstract: Scroll devices with cooling fluid supplied through a crankshaft are provided. The device may comprise an orbiting scroll operably connected to a fixed scroll and a crankshaft operably connected to the orbiting scroll. A first seal may be positioned about an outer surface of the crankshaft to form a seal with the outer surface. A second seal may be positioned about an outer surface of the crankshaft to form a seal with the outer surface. A first channel and a second channel extend through the crankshaft and are in fluid communication with the orbiting scroll and a fluid source and a fluid reservoir.

Abstract: Memory deterioration detection and evaluation includes capturing human utterances with a voice interface and generating, for a user, a human utterances corpus that comprises human utterances selected from the plurality of human utterances based on meanings of the human utterances as determined by natural language processing by a computer processor. Based on data generated in response to signals sensed by one or more sensing devices operatively coupled with the computer processor, contextual information corresponding to one or more human utterances of the corpus is determined. Patterns among the corpus of human utterances are recognized based on pattern recognition performed by the computer processor using one or more machine learning models. Based on the pattern recognition a change in memory functioning of the user is identified. The identified change is classified, based on the contextual information, as to whether the change is likely due to memory impairment of the user.