Abstract: Described herein are methods and compositions for treating gliomas such as pediatric low grade glioma. In some embodiments, a herein described method of treating pediatric low grade glioma comprises administering to a subject in need thereof (R)-2-(1-(6-amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide (Compound A), or a pharmaceutically acceptable salt thereof. In some embodiments, Compound A or a pharmaceutically acceptable salt thereof is administered in an amount that is equivalent to about 400 mg/m2 to about 600 mg/m2 of Compound A per week. In some embodiments, the subject is less than 20 years of age.

Abstract: Systems and methods are provided for fabricating a wing panel. Methods include aligning a strongback over a wing panel, vacuum attaching a wing panel surface and pogos extending beneath the strongback, and adjusting the length of pogos to enforce a contour to the wing panel. Systems include a strongback to extend over a wing panel, adjustable-length pogos extending beneath the strongback, and vacuum couplers to attach to a wing panel surface. Other systems include a track, work stations along the track, a strongback to extend over the wing panel and move along the track, adjustable-length pogos extending beneath the strongback, and vacuum couplers to attach to a wing panel surface. Apparatus includes a shuttle having adapters that mate the shuttle with a track, adjustable-length carriers with vacuum couplers to couple with a wing panel surface, and indexing units that interact with indexing features in a manufacturing excess of the wing panel.

Abstract: Described are multifocal contact lenses that contain high energy visible (HEV) light absorbing compounds and their use for improving one or more vision attributes.

Abstract: A fan with airfoil blades is provided for a regenerative air vacuum street sweeper. The blades are formed using cut and pressed upper and lower panels which are welded at a forward edge to a rod to form the airfoil leading edge and welded at the rear edges to form the airfoil trailing edge. Pins extend laterally outwardly from the rod for mounting each blade in corresponding holes in the front and rear plates of the fan housing. The side edges of the blade are welded to the plates at a 9-11° angle of attack. The airfoil blades allow for reduced size, horse power, noise, and manufacturing and shipping costs.

Abstract: A fan with airfoil blades is provided for a regenerative air vacuum street sweeper. The blades are formed using cut and pressed upper and lower panels which are welded at a forward edge to a rod to form the airfoil leading edge and welded at the rear edges to form the airfoil trailing edge. Pins extend laterally outwardly from the rod for mounting each blade in corresponding holes in the front and rear plates of the fan housing. The side edges of the blade are welded to the plates at a 9-11° angle of attack. The airfoil blades allow for reduced size, horse power, noise, and manufacturing and shipping costs.

Abstract: Systems and methods are provided for processing composite parts. One embodiment is a method for preparing a composite part for assembly. The method includes receiving a mandrel to which a composite part has been molded, and operating a work station to install an indexing feature into a manufacturing excess of the composite part.

Abstract: Described are polymerizable fused tricyclic compounds of formula I: wherein R1, R2, R3, m, n, t, and rings B, C, and D are as defined herein. The compounds absorb various wavelengths of ultraviolet and/or visible light (such as high energy visible light) and are suitable for incorporation in a variety of products, such as biomedical devices and ophthalmic devices.

Abstract: Described are polymerizable high energy light absorbing compounds. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices. Such devices exhibit a number of desirable properties, including favorable vision break-up times.

Abstract: Described are polymerizable high energy light absorbing compounds. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices. Such devices exhibit a number of desirable properties, including providing wearers with favorable optical quality.

Abstract: A communication networking system and a method of email communication is described, wherein a solicitor sends a solicitor communication to an email list a selected contact organization from a plurality of contact organizations listed on the website of the communication networking system for a fee; wherein the plurality of email list recipients of the contact organization's email list is not divulged to the solicitor. This communication networking system enables solicitor organizations and individuals to have access to the email recipients of contact organization's email list for soliciting support, information, business promotions, educational information, announcement and the like. Each contact organization may have associated geographical information, medical condition information and the like stored on the communication networking system database.

Abstract: Described are multifocal contact lenses that contain high energy visible (HEV) light absorbing compounds and their use for improving one or more vision attributes.

Abstract: An apparatus includes a shaft assembly, first and second electrode assemblies, and a controller. The shaft assembly is configured to fit in a nasal cavity of a patient. The first and second electrode assemblies are at the distal end of the shaft assembly. The second electrode assembly includes a stimulus electrode and a sensing electrode. The stimulus and sensing electrodes are positioned on opposing lateral sides in relation to the longitudinal axis of the shaft assembly. The controller is operable to generate an electrical signal to perform one or both of tissue ablation or denervation of a targeted nerve via the first electrode assembly, generate an electrical stimulus signal to stimulate the targeted nerve via the stimulus electrode of the second electrode assembly, and process a response signal received from the targeted nerve via the sensing electrode of the second electrode assembly.

Abstract: A reversible eye enhancement contact lens comprises a main body comprising a first surface and a second surface opposite the first surface, the main body having a diameter, a base curve, a peripheral thickness, and a center thickness, wherein, one or more of the diameter, the base curve, the peripheral thickness, or the center thickness are configured such that a dSag is less than 1.

Abstract: A method is used to insert an implant within a lateral wall of a nose of a patient. The method includes forming an initial incision with a surface of the lateral wall of the nose. A stylet is advanced within the lateral wall of the nose, thereby creating a pocket within the lateral wall of the nose. The stylet is further advanced until an expanding body of the stylet is at least partially housed within the pocket of the lateral wall. The expanding body of the stylet is enlarged to thereby enlarge the pocket within the lateral wall. The implant is placed within the enlarged pocket of the lateral wall.

Abstract: Described are polymerizable high energy light absorbing compounds. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

Abstract: Described are polymerizable high energy light absorbing compounds. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices. Such devices exhibit a number of desirable properties, including favorable rates of pervaporation.

Abstract: A clamp includes first and second bands, a pair of strut attachment legs, a screw, and a screw housing. Each band has a first end and a second end. The first band defines slots extending across a width thereof and disposed adjacent to the second end thereof. Each strut attachment leg is fixed to the first end of one of the bands. The screw housing receives the second ends of the bands and captures the screw while allowing the screw to rotate. The clamp secures a tube to a strut when the clamp is placed over the tube, the strut attachment legs are positioned relative to the strut so that notches in the strut attachment legs receive at least one of the flanges on the strut, and the screw is rotated to draw the first band further into the screw housing and thereby tighten the clamp around the tube.

Abstract: A clamp includes first and second bands, a pair of strut attachment legs, a screw, and a screw housing. Each band has a first end and a second end. The first band defines slots extending across a width thereof and disposed adjacent to the second end thereof. Each strut attachment leg is fixed to the first end of one of the bands. The screw housing receives the second ends of the bands and captures the screw while allowing the screw to rotate. The clamp secures a tube to a strut when the clamp is placed over the tube, the strut attachment legs are positioned relative to the strut so that notches in the strut attachment legs receive at least one of the flanges on the strut, and the screw is rotated to draw the first band further into the screw housing and thereby tighten the clamp around the tube.

Abstract: A hybridization probe solution containing at least one hybridization probe is applied to final sample handling blank(s) to produce baited final sample handling blank(s), and identical hybridization probe is applied to final control blank(s) carrying transfer substrate identical to that applied to the sample handling blank(s) but isolated from the sample biological materials, to thereby produce at least one baited final control blank. The baited final sample handling blank(s) and baited final control blank(s) are fed into a DNA sequencer to sequence sample bait-captured DNA carried by the baited final sample handling blank and control bait-captured DNA carried by the baited final control blank, respectively. The sample bait-captured DNA is compared to the control bait-captured DNA and genetic components that are common to the final sample handling blank and the final control blank and pass a statistical significance test are discounted from a final identified genetic sequence.

Abstract: An ENT surgical instrument includes a shaft assembly, a flexible substrate, and at least at least one electrically-conductive sensor trace formed on the flexible substrate. The shaft assembly has a distal end sized and configured to fit in an anatomical passageway in an ear, nose, or throat of a patient. The flexible substrate extends along at least a portion of the shaft. The at least one sensor trace includes at least one concentric loop portion, wherein the at least one concentric loop portion defines at least one navigation sensor.