Abstract: This invention relates to a novel synthetic method for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid.

Abstract: This invention relates to a novel synthetic method for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid.

Abstract: Iron nanoparticles that are useful for constructing electrodes for lithium ion batteries and a method of making said particles is disclosed herein. The nanoparticles may include magnetite. The electrode may be constructed by centrifuging the nanoparticles to a current collector, such as a disc of copper, without the use of an extrinsic binder. The solvothermal method of making nanoparticles decreases the time of the procedure from about 24 hours to about 75 minutes. The method of making electrode decreases the complexity and number of steps compared to the conventional procedure to prepare an electrode, and eliminates the use of additives (binder and current enhancer) and toxic NMP solvents in the electrode preparation process.

Abstract: The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I wherein R1 and R2 independently denote C1-3-alkyl groups and X? denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

Abstract: A device for separating liquids such as oil and water includes a hydrophobic and oleophilic mesh that allows oil to pass through while preventing water from passing through. The mesh can be fabricated simply from inexpensive materials by coating a mesh with a hydrophobic polymer.

Abstract: The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I wherein R1 and R2 independently denote C1-3-alkyl groups and X? denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

Abstract: Disclosed is a method for the synthesis of N—H or N-alkyl 2-propynamides useful as intermediate in the manufacture of pharmaceutically active ingredients.

Abstract: Disclosed is a method for the synthesis of N—H or N-alkyl 2-propynamides useful as intermediate in the manufacture of pharmaceutically active ingredients.