Abstract: A point-to-point autonomous driving path generation and driving control method based on a navigation route and a high definition map, which generates a point-to-point autonomous driving path by utilizing both of a route made with a navigation map (SD map) and a lane centerline of a high definition map (HD map). The point-to-point autonomous driving path generation and driving control method based on the navigation route and the high definition map includes a step of acquiring navigation route data; and a step of generating autonomous driving trajectory data on the basis of lane information of the high definition map matched with the navigation route data.