Abstract: The present disclosure provides a stapled peptide and use thereof in preparation of a drug for treating pancreatic cancer, belonging to the technical field of biomedicine. The stapled peptide is prepared by using a linear peptide with an amino acid sequence shown in SEQ ID NO: 1 as a peptide chain template, and replacing i-th and (i+7)-th amino acids of the linear peptide with S5 separately and conducting cyclization; alternatively, replacing n-th and (n+4)-th amino acids of the linear peptide with S5 separately and conducting cyclization; where S5 is 2-amino-2-methyl-6-heptenoic acid; i is a positive integer of less than or equal to 7, and n is a positive integer of less than or equal to 10. The stapled peptide treats LINC00261-deficient pancreatic cancer, N1DARP-deficient pancreatic cancer, or gemcitabine-resistant pancreatic cancer by specifically inhibiting a deubiquitination activity of USP10.

Abstract: The present disclosure provides a stapled peptide and use thereof in preparation of a drug for treating pancreatic cancer, belonging to the technical field of biomedicine. The stapled peptide is prepared by using a linear peptide with an amino acid sequence shown in SEQ ID NO: 1 as a peptide chain template, and replacing i-th and (i+7)-th amino acids of the linear peptide with S5 separately and conducting cyclization; alternatively, replacing n-th and (n+4)-th amino acids of the linear peptide with S5 separately and conducting cyclization; where S5 is 2-amino-2-methyl-6-heptenoic acid; i is a positive integer of less than or equal to 7, and n is a positive integer of less than or equal to 10. The stapled peptide treats LINC00261-deficient pancreatic cancer, N1DARP-deficient pancreatic cancer, or gemcitabine-resistant pancreatic cancer by specifically inhibiting a deubiquitination activity of USP10.

Abstract: The present invention provides a mobile terminal anti-theft method (100) which comprises triggering mobile terminal anti-theft operations according to operations on a mobile terminal (S110). The mobile terminal anti-theft operations at least comprise: collecting location information and environment information of the mobile terminal (S122, S124) and backing up private data of the mobile terminal (S126) and sending the collected location information and environment information and the backup private data to a result designated location (S130). The present disclosure further provides a mobile terminal (200) for achieving the mobile terminal anti-theft method (100).

Abstract: A service management platform provides a manager device the ability to provision, manage, and monitor managed devices through a manager device interface to the service management platform. The service management platform allows for a manager device to configure and modify various profiles by determining one or more governing policies to be associated with respective profiles. The service management platform allows for the manager device to provision managed devices by the service management platform applying selected profiles to respective selected devices. The service management platform further allows for the manager device to monitor one or more managed devices by providing managed device usage data to the manager device, based on requests originating at the manager device.