Abstract: Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

Abstract: The hose clamp includes a clamp body formed by bending a resilient plate-shaped member of a stainless steel material, a fastening screw having a head and coupled with a fastening housing which is secured to one end of the clamp body, and a plurality of screw holes formed inwards at the other end of the clamp body to be engaged with the fastening screw, and a compensation bead integrally formed with the clamp body for restraining and firmly fastening the hose in an amount being reduced as the diameter of the hose is decreased due to long-term use, wherein the compensation bead further includes a plastic deformation prevention means, to prevent the compensation bead from not being restored to its original state due to loss of its elasticity by a plastic deformation.