Patents by Inventor Da-Jeng Yao
Da-Jeng Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11196358Abstract: An automatic powering device includes a dielectric layer, a driving layer, a plurality of electrodes and a droplet. The dielectric layer includes a first surface and a second surface opposite to the first surface. The driving layer faces toward the dielectric layer thereby forming a channel between the driving layer and the dielectric layer. The driving layer includes a plurality of hydrophilic surfaces facing toward the first surface and a plurality of hydrophobic surfaces facing toward the first surface. Each of the hydrophilic surfaces is staggered from each of the hydrophobic surfaces. The electrodes are disposed at the second surfaces. The electrodes each are electrically connected to and spaced from each other. The droplet is flowable within the channel. The droplet is affected by the hydrophilic surfaces and the hydrophobic surfaces so as to flow in the channel.Type: GrantFiled: April 9, 2020Date of Patent: December 7, 2021Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Zong-Hong Lin, Da-Jeng Yao, Hsuan-Yu Lin
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Publication number: 20210226558Abstract: An automatic powering device includes a dielectric layer, a driving layer, a plurality of electrodes and a droplet. The dielectric layer includes a first surface and a second surface opposite to the first surface. The driving layer faces toward the dielectric layer thereby forming a channel between the driving layer and the dielectric layer. The driving layer includes a plurality of hydrophilic surfaces facing toward the first surface and a plurality of hydrophobic surfaces facing toward the first surface. Each of the hydrophilic surfaces is staggered from each of the hydrophobic surfaces. The electrodes are disposed at the second surfaces. The electrodes each are electrically connected to and spaced from each other. The droplet is flowable within the channel. The droplet is affected by the hydrophilic surfaces and the hydrophobic surfaces so as to flow in the channel.Type: ApplicationFiled: April 9, 2020Publication date: July 22, 2021Inventors: Zong-Hong LIN, Da-Jeng YAO, Hsuan-Yu LIN
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Patent number: 10288979Abstract: The present disclosure describes the design and fabrication of a Terahertz (THz) beam steering device and a multifunctional patternless flat lens using electro-optic tunable fishnet materials (TFMM) to create a portable THz imaging system. The THz beam steering device and multifunctional patternless flat lens utilize a tunable resonant frequency of TFMM (with a negative refraction index) to achieve a maximum beam steering angle (field of view) and beam modulation. The portable THz scanning system is made by combining the TFMM beam steering device with a pair of continuous wave (CW) photomixer modules powered by two tunable CW lasers with built-in optical isolators, a fiber-optic beam combination and a multifunctional flat lens.Type: GrantFiled: December 12, 2017Date of Patent: May 14, 2019Assignee: National Tsinghua UniversityInventors: Wei-Chih Wang, Chi-Leung Tsui, Da-Jeng Yao
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Patent number: 9758754Abstract: A cell separation and culture device having a porous substrate; and a patterned carbon powder layer having a plurality of hollow regions, formed on an upper surface of the porous substrate by a forming manner; wherein the thickness of the patterned carbon powder layer is 0.04-0.08 mm. The cell separation and culture device is able to separate, detect or culture cells with various size and shape. The cell separation and culture device of present invention also simplifies the process of cell separation, detection and culture; therefore, it is accomplished within a very short time.Type: GrantFiled: January 29, 2015Date of Patent: September 12, 2017Assignee: National Tsing Hua UniversityInventors: Da-Jeng Yao, Chih-Chung Chen
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Patent number: 9746465Abstract: A magnetic bead-based digital microfluidic immunoanalysis device and a method thereof are provided, which includes a lower plate, an upper plate disposed above the lower plate, a separating structure therebetween and a magnet disposed on the upper plate or the lower plate. The lower plate includes a first electrode layer including a plurality of channel electrodes with different sizes. A droplet containing few magnetic beads is adapted to be disposed on the lower plate and corresponding to the channel electrodes. The magnet attracts the magnetic beads to approach to the smaller one of the channel electrodes though a magnetic force, and when a voltage is applied to the first electrode layer, the droplet is divided to a detection portion with the magnetic beads and a waste-liquid portion without the magnetic beads respectively corresponding to the smaller one and the larger one of the channel electrodes through a dual-direction electrowetting-on-dielectric force.Type: GrantFiled: June 15, 2015Date of Patent: August 29, 2017Assignee: National Chiao Tung UniversityInventors: Wensyang Hsu, Cheng-Yeh Huang, Po-Yen Tsai, Po-Huai Shih, Shih-Kang Fan, Da-Jeng Yao, Cheng-Hsien Liu, Hong-Yuan Huang
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Patent number: 9689869Abstract: A portable fluorescence analysis system comprises a fluorescence strip, a fluorescence excitation device and a mobile Internet device. The fluorescence strip comprises a fluorescence probe configured for detecting an analyte within a specimen. The fluorescence excitation device comprises a sleeve and an excitation light source module. The fluorescence strip is arranged at the one open end of the sleeve. The excitation light source module is arranged at the same opening side of the sleeve and configured for providing an excitation light to excite the fluorescence probe to generate fluorescence. The mobile Internet device comprises an image capturing module and configured for capturing a fluorescence image of the fluorescence strip via the other opening of the sleeve and analyzing fluorescence intensity of the fluorescence image to determine the content of the analyte. The above-mentioned system can be applied to the point of care testing.Type: GrantFiled: December 23, 2015Date of Patent: June 27, 2017Assignee: National Tsing Hua UniversityInventors: Shih-Jie Lo, Min-Wei Hung, Jer-Liang Yeh, Da-Jeng Yao, Chao-Min Cheng
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Patent number: 9663751Abstract: The present disclosure illustrates a platform system for in vitro cell co-cultivation with automatic trapping function. The platform system aims to develop a bio-chip applied in cell culture systems, and has several features. The first feature is that this co-cultivation platform can construct a micro environment suitable for culture of various cells. The second feature is dynamic perfusion. The microfluidic system is used to dynamically replace the culture medium, in order to maintain an appropriate environment for the growth of cells. The third feature is the automatic trapping. The cells to be cultured can be trapped in a suitable location according to the flow resistance, so that the damaged on the cell caused by manual operation can be minimized.Type: GrantFiled: January 2, 2015Date of Patent: May 30, 2017Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Ting-Ju Yueh, Chi-Fan Chen, Kuo-Wei Chang, Pei-Yu Chang, Cheng-Hsien Liu, Hong-Yuan Huang, Chin-Jung Li, Chang-Hung Tien, Da-Jeng Yao, Shih-Kang Fan, Wen-Syang Hsu
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Publication number: 20160324479Abstract: A handheld gas sensing device and sensing method thereof are provided. The handheld gas sensing device includes a plurality of gas sensing chips and a gas collector. The plurality of gas sensing chips respectively include a sensing array, a sensing interface circuit, a microcontroller, and a memory. The gas signal is determined by the gas adsorption of the sensing array. The gas signal is converted to a visible operand by using the sensing interface circuit. The visible operand is projected to a hidden operand by utilizing the calculation of Continuous Restricted Boltzmnan Machine (CRBM). The plurality of gas sensing chips are connected with each other to do the multi-layer calculation of CRBM. The probability of the to-be-detected gas is obtained. The result is recorded in the memory.Type: ApplicationFiled: August 20, 2015Publication date: November 10, 2016Inventors: Kea-Tiong TANG, Shih-Wen CHIU, Chung-Hung SHIH, Li-Chun WANG, Hsin CHEN, Yi-Wen LIU, Chia-Min YANG, Da-Jeng YAO
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Publication number: 20160274098Abstract: A magnetic bead-based digital microfluidic immunoanalysis device and a method thereof are provided, which includes a lower plate, an upper plate disposed above the lower plate, a separating structure therebetween and a magnet disposed on the upper plate or the lower plate. The lower plate includes a first electrode layer including a plurality of channel electrodes with different sizes. A droplet containing few magnetic beads is adapted to be disposed on the lower plate and corresponding to the channel electrodes. The magnet attracts the magnetic beads to approach to the smaller one of the channel electrodes though a magnetic force, and when a voltage is applied to the first electrode layer, the droplet is divided to a detection portion with the magnetic beads and a waste-liquid portion without the magnetic beads respectively corresponding to the smaller one and the larger one of the channel electrodes through a dual-direction electrowetting-on-dielectric force.Type: ApplicationFiled: June 15, 2015Publication date: September 22, 2016Inventors: Wensyang Hsu, Cheng-Yeh Huang, Po-Yen Tsai, Po-Huai Shih, Shih-Kang Fan, Da-Jeng Yao, Cheng-Hsien Liu, Hong-Yuan Huang
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Patent number: 9448217Abstract: A gas sensing system includes an air intake hole which comprises a plurality of micro-flow channels, a replaceable sensor for receiving an air from the air intake hole and detecting the received air, and a processing unit coupled to the replaceable sensor and doing determination for the component of the air according to a detection result of the replaceable sensor. Wherein, the replaceable sensor includes a plurality of sensing chips arranged in an array and each sensing chip is coated with a sensing thin film separately to detect a different gas.Type: GrantFiled: March 3, 2014Date of Patent: September 20, 2016Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Hsiang-Chiu Wu, Shih-Wen Chiu, Ting-I Chou, Chia-Min Yang, Da-Jeng Yao, Hsin Chen, Kea-Tiong Tang
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Publication number: 20160122699Abstract: The present invention provides a cell separation and culture device, comprising: a porous substrate; and a patterned carbon powder layer having a plurality of hollow regions, formed on an upper surface of the porous substrate by a forming manner; wherein the thickness of the patterned carbon powder layer is 0.04-0.08 mm. By the features of the present invention, the cell separation and culture device of the present invention is able to separate, detect or culture cells with various size and shape. The cell separation and culture device of present invention also could simplify the process of cell separation, detection and culture; therefore, we could take very short time to accomplish.Type: ApplicationFiled: January 29, 2015Publication date: May 5, 2016Inventors: Da-Jeng Yao, Chih-Chung Chen
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Publication number: 20160116465Abstract: A portable fluorescence analysis system comprises a fluorescence strip, a fluorescence excitation device and a mobile Internet device. The fluorescence strip comprises a fluorescence probe configured for detecting an analyte within a specimen. The fluorescence excitation device comprises a sleeve and an excitation light source module. The fluorescence strip is arranged at the one open end of the sleeve. The excitation light source module is arranged at the same opening side of the sleeve and configured for providing an excitation light to excite the fluorescence probe to generate fluorescence. The mobile Internet device comprises an image capturing module and configured for capturing a fluorescence image of the fluorescence strip via the other opening of the sleeve and analyzing fluorescence intensity of the fluorescence image to determine the content of the analyte. The above-mentioned system can be applied to the point of care testing.Type: ApplicationFiled: December 23, 2015Publication date: April 28, 2016Inventors: Shih-Jie Lo, Min-Wei Hung, Jer-Liang Yeh, Da-Jeng Yao, Chao-Min Cheng
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Patent number: 9255884Abstract: A portable fluorescence analysis system comprises a fluorescence strip, a fluorescence excitation device and a mobile Internet device. The fluorescence strip comprises a fluorescence probe configured for detecting an analyte within a specimen. The fluorescence excitation device comprises a sleeve and an excitation light source module. The fluorescence strip is arranged at the one open end of the sleeve. The excitation light source module is arranged at the same opening side of the sleeve and configured for providing an excitation light to excite the fluorescence probe to generate fluorescence. The mobile Internet device comprises an image capturing module and configured for capturing a fluorescence image of the fluorescence strip via the other opening of the sleeve and analyzing fluorescence intensity of the fluorescence image to determine the content of the analyte. The above-mentioned system can be applied to the point of care testing.Type: GrantFiled: February 14, 2014Date of Patent: February 9, 2016Assignee: National Tsing Hua UniversityInventors: Shih-Jie Lo, Min-Wei Hung, Jer-Liang Yeh, Da-Jeng Yao, Chao-Min Cheng
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Publication number: 20150291926Abstract: The present disclosure illustrates a platform system for in vitro cell co-cultivation with automatic trapping function. The platform system aims to develop a bio-chip applied in cell culture systems, and has several features. The first feature is that this co-cultivation platform can construct a micro environment suitable for culture of various cells. The second feature is dynamic perfusion. The microfluidic system is used to dynamically replace the culture medium, in order to maintain an appropriate environment for the growth of cells. The third feature is the automatic trapping. The cells to be cultured can be trapped in a suitable location according to the flow resistance, so that the damaged on the cell caused by manual operation can be minimized.Type: ApplicationFiled: January 2, 2015Publication date: October 15, 2015Inventors: Ting-Ju YUEH, Chi-Fan CHEN, Kuo-Wei CHANG, Pei-Yu CHANG, Cheng-Hsien LIU, Hong-Yuan HUANG, Chin-Jung LI, Chang-Hung TIEN, Da-Jeng YAO, Shih-Kang FAN, Wen-Syang HSU
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Patent number: 9125590Abstract: A medical ventilator capable of early detecting and recognizing types of pneumonia, a gas recognition chip, and a method for recognizing gas thereof are disclosed. The gas recognition chip of the medical ventilator comprises a sensor array, a sensor interface circuit, a stochastic neural network chip, a memory and a microcontroller. The sensor array receives a plurality of multiple types of gases to produce odor signals corresponding to each type of gas. The sensor interface circuit analyzes the odor signals to produce gas pattern signals corresponding to each type of gas. The stochastic neural network chip amplifies the differences between the gas pattern signals and performs dimensional reduction on the gas pattern signals to aid the analysis. The memory stores training data. The microcontroller performs a mixed gas recognizing algorithm to early detect and recognize the type of the pneumonia according to the gas training data.Type: GrantFiled: April 27, 2012Date of Patent: September 8, 2015Assignee: National Tsing Hua UniversityInventors: Kea-Tiong Tang, Chung-Hung Shih, Li-Chun Wang, Hsin Chen, Yi-Wen Liu, Jyuo-Min Shyu, Chia-Min Yang, Da-Jeng Yao
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Patent number: 9101943Abstract: The present invention provides a centrifugal particle separation and detection device, which can separate and detect particles according to the particle size. The centrifugal particle separate and detection device is practiced with a centrifuge to separate particles, and can be applied to cancer cell detection, blood lymphocyte isolation, tissue engineering, polynucleotide hybridization, microorganism separation and detection and fine chemical purification.Type: GrantFiled: December 5, 2012Date of Patent: August 11, 2015Assignee: NATIONAL TSING HUA UNIVERSITYInventors: Da-Jeng Yao, Chih-Chung Chen
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Publication number: 20150136600Abstract: A gas sensing system includes an air intake hole which comprises a plurality of micro-flow channels, a replaceable sensor for receiving an air from the air intake hole and detecting the received air, and a processing unit coupled to the replaceable sensor and doing determination for the component of the air according to a detection result of the replaceable sensor. Wherein, the replaceable sensor includes a plurality of sensing chips arranged in an array and each sensing chip is coated with a sensing thin film separately to detect a different gas.Type: ApplicationFiled: March 3, 2014Publication date: May 21, 2015Applicant: National Tsing Hua UniversityInventors: Hsiang-Chiu Wu, Shih-Wen Chiu, Ting-I Chou, Chia-Min Yang, Da-Jeng Yao, Hsin Chen, Kea-Tiong Tang
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Publication number: 20150137007Abstract: A portable fluorescence analysis system comprises a fluorescence strip, a fluorescence excitation device and a mobile Internet device. The fluorescence strip comprises a fluorescence probe configured for detecting an analyte within a specimen. The fluorescence excitation device comprises a sleeve and an excitation light source module. The fluorescence strip is arranged at the one open end of the sleeve. The excitation light source module is arranged at the same opening side of the sleeve and configured for providing an excitation light to excite the fluorescence probe to generate fluorescence. The mobile Internet device comprises an image capturing module and configured for capturing a fluorescence image of the fluorescence strip via the other opening of the sleeve and analyzing fluorescence intensity of the fluorescence image to determine the content of the analyte. The above-mentioned system can be applied to the point of care testing.Type: ApplicationFiled: February 14, 2014Publication date: May 21, 2015Applicant: National Tsing Hua UniversityInventors: Shih-Jie LO, Min-Wei HUNG, Jer-Liang YEH, Da-Jeng YAO, Chao-Min CHENG
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Publication number: 20150065397Abstract: An assay assembly includes an assay plate. The assay plate includes at least one hydrophobic area and a plurality of hydrophilic areas defined by the hydrophobic area, wherein the hydrophilic areas are defined as a plurality of assay areas. Due to the specialized structure of the assay plate, droplets around the assay areas are drawn to the assay area by pushing force of the hydrophobic area and the pulling force of the assay area. In addition, the shaker is coupled to the assay plate and configured for shaking the assay plate thereby droplets around the assay areas are further drawn to the assay area by shaking of the shaker. The present invention may improve the error-tolerance rate of the assay plate and be used for high-throughput screening.Type: ApplicationFiled: September 30, 2013Publication date: March 5, 2015Applicant: National Tsing Hua UniversityInventors: Shih-Jie LO, Da-Jeng YAO, Kuan-Hung CHEN, Chao-Min CHENG
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Publication number: 20140045249Abstract: The present invention provides a centrifugal particle separation and detection device, which can separate and detect particles according to the particle size. The centrifugal particle separate and detection device is practiced with a centrifuge to separate particles, and can be applied to cancer cell detection, blood lymphocyte isolation, tissue engineering, polynucleotide hybridization, microorganism separation and detection and fine chemical purification.Type: ApplicationFiled: December 5, 2012Publication date: February 13, 2014Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Da-Jeng Yao, Chih-Chung Chen