Abstract: A plasmid vector comprising one or more heterologous nucleic acids or genes encoding a functional therapeutic protein configured to treat a retinal or ocular includes a human GRK1 promoter and human S/MAR enhancer to express the heterologous gene in both rod and cone photoreceptors.

Abstract: A compound comprising formula (I): wherein R1 is an akylamino group or a group containing at least one aromatic group; R2 and R3 are independently an aliphatic group or hydrophobic group; R4 and R5 are independently H, a substituted or unsubstituted akyl group, an akenyl group, an acyl group, an aromatic group, polymer, a targeting group, or a detectable moiety; a, b, c, and d are independently an integer from 1 to 10; and pharmaceutically acceptable salts thereof.

Abstract: A method for inducing non-hepatocytes into hepatocyte-like cells, wherein the non-hepatocytes are induced to express or overexpress hepatic fate conversion and maturation factors, cultured in somatic cell culture medium, hepatocyte expansion culture medium and 2C medium for a sufficient period of time to convert the non-hepatocyte cell into cells with hepatocyte-like properties, are provided. The iHeps induced according to the methods are also provided.

Abstract: A compound comprising formula (I): wherein R1 is an akylamino group or a group containing at least one aromatic group; R2 and R3 are independently an aliphatic group or hydrophobic group; R4 and R5 are independently H, a substituted or unsubstituted akyl group, an akenyl group, an acyl group, an aromatic group, polymer, a targeting group, or a detectable moiety; a, b, c, and d are independently an integer from 1 to 10; and pharmaceutically acceptable salts thereof.

Abstract: A nanosized complex includes a nucleic acid and a compound comprising formula (I): wherein R1 is an alkylamino group or a group containing at least one aromatic group; R2 and R3 are independently an aliphatic group or hydrophobic group; R4 and R5 are independently H, a substituted or unsubstituted alkyl group, an alkenyl group, an acyl group, or an aromatic group, or a polymer, a targeting group, a detectable moiety, or a linker, or a combination thereof, and at least one of R4 and R5 includes a retinoid or retinoid derivative that targets and/or binds to an interphotoreceptor retinoid binding protein; a, b, c, and d are independently an integer from 1 to 10; and pharmaceutically acceptable salts thereof.

Abstract: A compound comprising formula (I): wherein R1 is an alkylamino group or a group containing at least one aromatic group; R2 and R3 are independently an aliphatic group or hydrophobic group; R4 and R5 are independently H, a substituted or unsubstituted alkyl group, an alkenyl group, an acyl group, or an aromatic group, or includes a polymer, a targeting group, or a detectable moiety, and at least one of R4 and R5 includes a targeting group that targets and/or binds to a retinal or visual protein; a, b, c, and d are independently an integer from 1 to 10; and pharmaceutically acceptable salts thereof.

Abstract: A compound comprising formula (I): wherein R1 is an alkylamino group or a group containing at least one aromatic group; R2 and R3 are independently an aliphatic group or hydrophobic group; R4 and R5 are independently H, a substituted or unsubstituted alkyl group, an alkenyl group, an acyl group, or an aromatic group, or includes a polymer, a targeting group, or a detectable moiety, and at least one of R4 and R5 includes a targeting group that targets and/or binds to a retinal or visual protein; a, b, c, and d are independently an integer from 1 to 10; and pharmaceutically acceptable salts thereof.

Abstract: A bezel mounting assembly of the present invention includes a bezel (10), a front panel (30) defining a pair of first slots (32) therein, and an arc-shape resilient member (20) attached to the bezel for detaching the bezel from the front panel. The bezel includes a pair of first hooks (12) corresponding to the first slots of the front panel. A pair of retaining pieces (16) is formed on the bezel and each defines a sliding slot (17) therein. A cutout (18) is defined in a bottommost portion of the bezel. The resilient member includes a pressing portion (22). A number of protrusions (26) are formed on the resilient member and are received in the corresponding sliding slots of the bezel. The pressing portion is pressed to drive the first hook outwardly; the first hooks are thereby disengaged from the first slots of the front panel.

Abstract: A drive bracket (10) includes a locking device (30) to secure data storage devices (50) therein. The drive bracket has a bottom plate (11), and first and second side plates (12, 13). A plurality of slots (16) is defined in the side plates. The locking device is attached to the first side plate, and defines openings (31) corresponding to the slots. Two connecting arms (33) extend from the locking device in each opening. A handle (34) extends forwardly and outwardly from the connecting arms. A fastening portion (35) extends rearward and inwardly from the handle between junctions of the handle and the connecting arms. Pins (54) of each data storage device slide in the slots, with one leading pin riding over the fastening portion, and restrained by an end of the fastening portion. When the handle is pushed, the fastening portion is moved outwardly, and disengaged from the leading pin.

Abstract: A control method and device for a monitor, which is used for controlling the brightness, the vertical size, the horizontal size and the contrast of a monitor screen; by means of the minor and slow variation of the size and contrast of the monitor screen, a user's pupils can move naturally so as to reduce the fatigue of a user's: eyes. When the time set is up, a voice will be sent out to remind a user to have a break. The aforesaid device comprises an input setting unit, a microprocessor, a vertical size control circuit assembly, a horizontal size control circuit assembly, a contrast-control circuit assembly, a brightness-control circuit assembly, a voice module, a sensor, a power-supply control module, and a manual/automatic switch.