Patents by Inventor Daan Van Aalten

Daan Van Aalten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for designing a compound based on the three dimensional structure of phosphoinositide dependent protein kinase 1 (PDK1)
    Patent number: 7792665
    Abstract: A method for selecting a compound for modulating the activity of phosphoinositide dependent protein kinase 1 (PDKI) is provided. The method may comprise modelling a three dimensional structure of a plurality of molecules in a computer, comparing with the three dimensional structure of the compounds with that of a reference structure such as at least part of a protein kinase catalytic domain of PDK1, and selecting the compound based on a predicted interacting ability of the molecules to the protein kinase catalytic domain. Also a method for selecting a compound for modulating the activity of hydrophobic pocket containing protein kinase is provided. In this method, the reference structures may be one or more of a phosphate binding pocket of PDK1, a hydrophobic pocket of PDK1, and ?C helix or region interacting therewith of PDK1.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: September 7, 2010
    Assignee: Medical Research Council
    Inventors: Dario Alessi, Ricardo Biondi, David Komander, Daan Van Aalten