Abstract: Provided herein are the compositions and methods of manufacturing of injectable gels of cross-linked hyaluronic acid associated to a varying degree with hydroxyapatite.

Abstract: The disclosure relates to a device for creating an intradermal channel in a skin tissue of a patient, with a thread. The device can include a main body, a penetration element, and a displacement mechanism. The main body can have a lumen. The penetration element can be at a distal end of the main body and have a cannula which is configured to contain the thread in its entirety. The displacement mechanism can have at least a portion thereof permanently contained within the lumen of the main body. The displacement mechanism can be configured to effect a relative motion between the cannula and the thread, thereby to expose at least a portion of the thread to a patient's tissue within an intradermal channel.

Abstract: Pharmaceutical compositions, more specifically poloxamer copolymer-based compositions and hyaluronic acid-based compositions, containing amelogenin, are useful for promoting periodontal or orthopedic soft or hard tissue regeneration, wound closure, and skin regeneration and rejuvenation. The composition can contain a non-biodegradable thermosensitive pharmaceutically acceptable poloxamer copolymer in an amount of 18% to 30% by weight; amelogenin in an amount of 0.005% to 3% by weight; a disaccharide in an amount of 0.05% to 5% by weight; and an amino acid selected from alanine, glycine, isoleucine, leucine, proline, valine, and a mixture thereof in an amount of 0.05% to 5% by weight.

Abstract: Disclosed herein are threads of cross-linked hyaluronic acid and hydroxyapatite, the precursor compositions from which they are prepared and processes for their manufacturing.

Abstract: Provided herein are compositions, comprising hyaluronic acid in three different forms. The compositions are in a form of an essentially homogeneous gel with improved rheological properties enabling improved clinical performance.

Abstract: The present invention relates to a periodontal gel composition, more particularly to a liquid composition having a low viscosity at ambient temperature, which upon warming to body temperature solidifies into a viscous gel and then releases a therapeutic agent, e.g., an antibacterial agent, in a sustained release manner; and to a method of use.

Abstract: The present invention relates to a periodontal gel composition, more particularly to a liquid composition having a low viscosity at ambient temperature, which upon warming to body temperature solidifies into a viscous gel and then releases a therapeutic agent, e.g., an antibacterial agent, in a sustained release manner; and to a method of use.

Abstract: Disclosed herein are threads of cross-linked hyaluronic acid and hydroxyapatite, the precursor compositions from which they are prepared and processes for their manufacturing.

Abstract: Provided herein are the compositions and methods of manufacturing of injectable gels of cross-linked hyaluronic acid associated to a varying degree with hydroxyapatite.

Abstract: A penile desensitizing formulation for treating premature ejaculation, comprising benzyl alcohol at a concentration between 1% and 10% by weight of the total formulation, and additionally menthol at a concentration between 0.05% and 1% by weight of the total formulation, prepared as solution, gel, cream or ointment.