Patents by Inventor Dae Eun KI

Dae Eun KI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12188026
    Abstract: Provided is a surface expression vector having pgsA, a gene encoding poly-gamma-glutamate synthetase, and a method of expressing a target protein on the microbial surface using the vector. The vector having foreign genes inserted therein is transformed into a microorganism and allows a foreign protein to be stably expressed on the surface of the microorganism.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: January 7, 2025
    Assignee: BIOLEADERS CORPORATION
    Inventors: Young Chul Park, Jae Won Jeon, Hong Gyu Park, Hyun Jun Kang, Se Eun Byeon, Kwang Seo Park, Dae Eun Ki
  • Patent number: 12188027
    Abstract: Provided is a vector capable of co-expressing two different target proteins on the microbial surface using two promoters derived from Lactobacillus, and a method of expressing target proteins on the microbial surface using the vector. The vector containing foreign genes inserted therein is transformed into a microorganism, and allows different foreign proteins to be stably expressed on the surface of the microorganism. Furthermore, provided is a surface expression vector containing the gene pgsA encoding a poly-gamma-glutamate synthetase complex, and a method of expressing a target protein on the microbial surface using the vector. The vector containing foreign genes inserted therein is transformed into a microorganism, and allows the foreign proteins to be stably expressed on the surface of the microorganism.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: January 7, 2025
    Assignee: BIOLEADERS CORPORATION
    Inventors: Young Chul Park, Dae Eun Ki, Gyeong Jun Nam, Se Eun Byeon, Ha Na Moon, Hyun Jun Kang, Kyung Soo Hahm
  • Patent number: 12180469
    Abstract: Provided is a galactose mutarotase gene promoter derived from Lactobacillus casei and the use thereof, and more particularly, to a Lactobacillus casei-derived galactose mutarotase gene promoter having the nucleotide sequence of SEQ ID NO: 1, an expression vector containing the promoter, and a microorganism transformed with the expression vector. A microorganism transformed with an expression vector containing the promoter may effectively express a target protein on the cell surface, and thus is useful as a vaccine vehicle or the like. Moreover, provided is a surface expression vector having pgsA, which is a gene encoding poly-gamma-glutamate synthetase, and a method of expressing a target protein on the microbial surface using the vector. The vector containing foreign genes inserted therein is transformed into a microorganism and allows a foreign protein is to be stably expressed on the surface of the microorganism.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: December 31, 2024
    Assignee: BIOLEADERS CORPORATION
    Inventors: Young Chul Park, Dae Eun Ki, Gyeong Jun Nam, Se Eun Byeon, Ha Na Moon, Hyun Jun Kang, Kyung Soo Hahm
  • Publication number: 20230295644
    Abstract: Provided is a vector capable of co-expressing two different target proteins on the microbial surface using two promoters derived from Lactobacillus, and a method of expressing target proteins on the microbial surface using the vector. The vector containing foreign genes inserted therein is transformed into a microorganism, and allows different foreign proteins to be stably expressed on the surface of the microorganism. Furthermore, provided is a surface expression vector containing the gene pgsA encoding a poly-gamma-glutamate synthetase complex, and a method of expressing a target protein on the microbial surface using the vector. The vector containing foreign genes inserted therein is transformed into a microorganism, and allows the foreign proteins to be stably expressed on the surface of the microorganism.
    Type: Application
    Filed: October 10, 2019
    Publication date: September 21, 2023
    Inventors: Young Chul PARK, Dae Eun KI, Gyeong Jun NAM, Se Eun BYEON, Ha Na MOON, Hyun Jun KANG, Kyung Soo HAHM
  • Publication number: 20220090099
    Abstract: Provided is a surface expression vector having pgsA, a gene encoding poly-gamma-glutamate synthetase, and a method of expressing a target protein on the microbial surface using the vector. The vector having foreign genes inserted therein is transformed into a microorganism and allows a foreign protein to be stably expressed on the surface of the microorganism.
    Type: Application
    Filed: June 24, 2019
    Publication date: March 24, 2022
    Inventors: Young Chul PARK, Jae Won JEON, Hong Gyu PARK, Hyun Jun KANG, Se Eun BYEON, Kwang Seo PARK, Dae Eun KI
  • Publication number: 20220033812
    Abstract: Provided is a galactose mutarotase gene promoter derived from Lactobacillus casei and the use thereof, and more particularly, to a Lactobacillus casei-derived galactose mutarotase gene promoter having the nucleotide sequence of SEQ ID NO: 1, an expression vector containing the promoter, and a microorganism transformed with the expression vector. A microorganism transformed with an expression vector containing the promoter may effectively express a target protein on the cell surface, and thus is useful as a vaccine vehicle or the like. Moreover, provided is a surface expression vector having pgsA, which is a gene encoding poly-gamma-glutamate synthetase, and a method of expressing a target protein on the microbial surface using the vector. The vector containing foreign genes inserted therein is transformed into a microorganism and allows a foreign protein is to be stably expressed on the surface of the microorganism.
    Type: Application
    Filed: October 10, 2019
    Publication date: February 3, 2022
    Inventors: Young Chul PARK, Dae Eun KI, Gyeong Jun NAM, Se Eun BYEON, Ha Na MOON, Hyun Jun KANG, Kyung Soo HAHM