Patents by Inventor Dae-Won Moon
Dae-Won Moon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240114679Abstract: A semiconductor memory device includes a substrate including an element separation film and an active region defined by the element separation film, a bit line structure on the substrate, a trench in the element separation film and the active region, the trench on at least one side of the bit line structure and including a first portion in the element separation film and a second portion in the active region, a bottom face of the first portion placed above a bottom face of the second portion, a single crystal storage contact filling the trench, and an information storage element electrically connected to the single crystal storage contact.Type: ApplicationFiled: December 13, 2023Publication date: April 4, 2024Applicant: Samsung Electronics Co., Ltd.Inventors: Jin Won MA, Ja Min KOO, Dae Young MOON, Kyu Wan KIM, Bong Hyun KIM, Young Seok KIM
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Patent number: 8871438Abstract: The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.Type: GrantFiled: August 9, 2012Date of Patent: October 28, 2014Assignee: Korea Research Institute of Standards and ScienceInventors: Tae Geol Lee, Dae Won Moon, Byong Chul Yoo, In Hoo Kim
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Patent number: 8772713Abstract: The present invention aims to provide a time-of-flight based mass microscope system for an ultra-high speed multi-mode mass analysis, for using a laser beam or an ion beam simultaneously to enable both a low molecular weight analysis such as for drugs/metabolome/lipids/peptides and a high molecular weight analysis such as for genes/proteins, without being limited by the molecular weight of the object being analyzed, and for significantly increasing the measuring speed by using a microscope method instead of a microprobe method.Type: GrantFiled: May 3, 2012Date of Patent: July 8, 2014Assignee: Korea Research Institute of Standards and ScienceInventors: Jeong Hee Moon, Dae Won Moon, Tae Geol Lee, Sohee Yoon, Ju Hwang Kim
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Publication number: 20140183354Abstract: The present invention aims to provide a time-of-flight based mass microscope system for an ultra-high speed multi-mode mass analysis, for using a laser beam or an ion beam simultaneously to enable both a low molecular weight analysis such as for drugs/metabolome/lipids/peptides and a high molecular weight analysis such as for genes/proteins, without being limited by the molecular weight of the object being analyzed, and for significantly increasing the measuring speed by using a microscope method instead of a microprobe method.Type: ApplicationFiled: May 3, 2012Publication date: July 3, 2014Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCEInventors: Jeong Hee Moon, Dae Won Moon, Tae Geol Lee, Sohee Yoon, Ju Hwang Kim
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Patent number: 8450684Abstract: A quantification method of functional groups in an organic thin layer includes: a) measuring an absolute quantity per unit area of an analysis reference material having functional groups included in a reference organic thin layer by means of MEIS spectroscopy; b) carrying out spectrometry for the same reference organic thin layer as in a) and thereby obtaining peak intensities of the functional groups in the reference organic thin layer; c) carrying out the same spectrometry as in b) for an organic thin layer to be analyzed having the same functional groups and thereby measuring peak intensities of the functional groups with unknown quantity; and d) comparing the peak intensities of the functional groups measured in b) with respect to the absolute quantity of the analysis reference material in a) and thereby determining the absolute quantity per unit area of the functional groups with unknown quantity measured in c).Type: GrantFiled: September 24, 2009Date of Patent: May 28, 2013Assignee: Korea Research Institute of Standards and ScienceInventors: Tae Geol Lee, Dae Won Moon, Hyegeun Min
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Publication number: 20130065266Abstract: The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.Type: ApplicationFiled: August 9, 2012Publication date: March 14, 2013Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCEInventors: Tae Geol Lee, Dae Won Moon, Byong Chul Yoo, In Hoo Kim
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Patent number: 8395117Abstract: Provided is a spectrophotometer using medium energy ion. The spectrophotometer using medium energy ion is configured to include: an ion source 10 generating ions; a collimator 20 collimating the ions as a parallel beam; an accelerator 30 accelerating the parallel beam; an ion beam pulse generator 40 pulsing the accelerated ion beam; a focusing objective 50 focusing the pulsed ion beam on a specimen 1; a detector 60 detecting a spectroscopic signal of scattered ion from a specimen 1; and a data analyzer 70 analyzing and processing the spectroscopic signal detected by the detector 60.Type: GrantFiled: July 28, 2009Date of Patent: March 12, 2013Assignees: K-MAC, Korea Research Institute of Standards and ScienceInventors: Dae Won Moon, Ju Hwang Kim, Yeon Jin Yi, Kyu-Sang Yu, Wan Sup Kim
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Patent number: 8283117Abstract: The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of- flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.Type: GrantFiled: June 25, 2008Date of Patent: October 9, 2012Assignee: Korea Research Institute of Standards and ScienceInventors: Tae Geol Lee, Dae Won Moon, Byong Chul Yoo, In Hoo Kim
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Patent number: 8203708Abstract: Disclosed is a spectrally encoded coherent anti-Stokes Raman scattering (CARS) endoscope that is capable of spatially encoding spectral dispersions of two light sources having frequency difference as much as a Raman shift and overlapping two laser beams on a position where a sample to be measured is placed, thereby acquiring a spatial distribution of CARS signals.Type: GrantFiled: November 27, 2008Date of Patent: June 19, 2012Assignee: Korea Research Institute of Standards and ScienceInventors: Eun Seong Lee, Jae Yong Lee, Dae Won Moon
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Publication number: 20120050720Abstract: Disclosed is a system for diagnosing the pathological change in lipids in blood vessels using coherent anti-strokes raman microscopy which can image lipids abnormally deposited on the deep intima of blood vessels and analyze the components of the imaged lipids, without labeling or destroying blood vessels, to diagnose minute pathological changes in the blood vessels, whereby the stage of progression of lipid-related diseases can be determined.Type: ApplicationFiled: May 11, 2009Publication date: March 1, 2012Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCEInventors: Se Hwa Kim, Jae Yong Lee, Eun Seong Lee, Dae Won Moon
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Patent number: 8064053Abstract: The present invention relates to a 3-color multiplex CARS spectrometer. In the 3-color multiplex CARS spectrometer, Raman resonance is achieved for multiple molecular vibrations of a sample by the combination of a short-wavelength pump beam generated by a broadband laser light source and a long-wavelength Stokes beam generated by a stable laser light source, and another short-wavelength laser beam having a narrow linewidth is then introduced separately to serve as a probe beam that interacts with the laser-driven sample, thereby generating CARS spectral signals whose wavelength components can be resolved. Accordingly, the 3-color multiplex CARS spectrometer solves problem of the conventional 2-color multiplex CARS spectroscopy in which the wavelength decomposition of CARS signals, necessary for high spectral resolution, is not possible with broadband pump light causing the CARS spectrum distortion.Type: GrantFiled: December 29, 2008Date of Patent: November 22, 2011Assignee: Korea Research Institute of Standards and ScienceInventors: Jae Yong Lee, Eun Seong Lee, Dae Won Moon
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Publication number: 20110163228Abstract: A quantification method of functional groups in an organic thin layer includes: a) measuring an absolute quantity per unit area of an analysis reference material having functional groups included in a reference organic thin layer by means of MEIS spectroscopy; b) carrying out spectrometry for the same reference organic thin layer as in a) and thereby obtaining peak intensities of the functional groups in the reference organic thin layer; c) carrying out the same spectrometry as in b) for an organic thin layer to be analyzed having the same functional groups and thereby measuring peak intensities of the functional groups with unknown quantity; and d) comparing the peak intensities of the functional groups measured in b) with respect to the absolute quantity of the analysis reference material in a) and thereby determining the absolute quantity per unit area of the functional groups with unknown quantity measured in c).Type: ApplicationFiled: September 24, 2009Publication date: July 7, 2011Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCEInventors: Tae Geol Lee, Dae Won Moon, Hyegeun Min
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Publication number: 20110152119Abstract: A method for direct quantification of the areal density (number per surface area of a substrate) of an analyte including a biochemical substance bound on the surface of a substrate and for direct quantification of the binding efficiency of biochemical substances is disclosed. Specifically, the areal density of an analyte including a biochemical substance bound on the surface of a substrate, and the binding efficiency between a first biochemical substance fixed on the substrate surface and a second biochemical substance is measured by ion scattering spectroscopy (ISS).Type: ApplicationFiled: August 21, 2009Publication date: June 23, 2011Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCEInventors: Tae Geol Lee, Dae Won Moon, Hye geun Min
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Publication number: 20110133081Abstract: Provided is a spectrophotometer using medium energy ion. The spectrophotometer using medium energy ion is configured to include: an ion source 10 generating ions; a collimator 20 collimating the ions as a parallel beam; an accelerator 30 accelerating the parallel beam; an ion beam pulse generator 40 pulsing the accelerated ion beam; a focusing objective 50 focusing the pulsed ion beam on a specimen 1; a detector 60 detecting a spectroscopic signal of scattered ion from a specimen 1; and a data analyzer 70 analyzing and processing the spectroscopic signal detected by the detector 60.Type: ApplicationFiled: July 28, 2009Publication date: June 9, 2011Applicants: K-MAC, KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCEInventors: Dae Won Moon, Ju Hwang Kim, Yeon Jin Yi, Kyu-Sang Yu, Wan Sup Kim
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Patent number: 7951572Abstract: Disclosed herein is a gold nanoparticle (AuNP)-based peptide chip prepared by forming a monolayer of AuNPs onto a self-assembled monolayer constructed on a solid support, and then immobilizing a peptide on the AuNPs. The AuNPs can effectively amplify the mass signal of the peptide, thus making it possible to measure the mass change of the peptide in a simple and accurate manner. Also, when secondary ion mass spectrometric analysis (spectrum or imaging) is performed on the AuNP-based peptide chip, the activities of enzymes and related inhibitors can be effectively quantified. The disclosed invention enables various enzyme activities to be analyzed rapidly and accurately, and thus can provide an important method for disease diagnosis and new drug development through the elucidation of signaling and interaction mechanisms.Type: GrantFiled: February 27, 2007Date of Patent: May 31, 2011Assignees: Korea Advanced Institute of Science and Technology, Korea Research Institute of Standards and ScienceInventors: Hak-Sung Kim, Young-Pil Kim, Eunkeu Oh, Mi-Young Hong, Dohoon Lee, Tae Geol Lee, Dae Won Moon
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Publication number: 20110101217Abstract: Disclosed is a method for carrying out matrix-free mass spectrometry, which includes subjecting an analyte sample containing a self-assembled monolayer on the surface of a substrate to laser desorption/ionization. The method for carrying out matrix-free mass spectrometry involves simple pretreatment of an analyte sample with a cationic solution without using any solid matrix to cause effective laser desorption/ionization of the analyte sample, and minimizes a biochemical and physiological change in the sample that may occur during the pretreatment of the sample. In addition, the method is applicable to quantitative analysis because it provides high reproducibility of the results by virtue of the uniform treatment with the cationic solution over the whole areas of the sample. Further, the method enables two-dimensional mapping analysis.Type: ApplicationFiled: April 24, 2009Publication date: May 5, 2011Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCEInventors: Sang Yun Han, Tae Geol Lee, Dae Won Moon
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Publication number: 20110095179Abstract: The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/s) peaks of biological samples measured using a time-of- flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.Type: ApplicationFiled: June 25, 2008Publication date: April 28, 2011Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCEInventors: Tae Geol Lee, Dae Won Moon, Byong Chul Yoo, In Hoo Kim
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Patent number: 7838257Abstract: A method of evaluating conjugation between materials using imaging of time-of-flight secondary ion mass spectrometry (TOF-SIMS) according to the present invention is carried out by following the steps, a) forming a spontaneous pattern on a substrate with a mixture containing nanoparticles and a conjugation material selected from organic, bio or inorganic material, b) obtaining an ion detection pattern from the conjugation material and nanoparticles, respectively, depending on their position on the substrate by using time-of-flight secondary ion mass spectrometry, and c) determining whether the conjugation is formed between the conjugation material and nanoparticles by comparing the ion detection pattern of the conjugation material with the ion detection pattern of the nanoparticles.Type: GrantFiled: April 29, 2008Date of Patent: November 23, 2010Assignee: Korea Research Institute of Standards and ScienceInventors: Tea Geol Lee, Hyegeun Min, Dae Won Moon
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Publication number: 20100174145Abstract: Disclosed is a spectrally encoded coherent anti-Stokes Raman scattering (CARS) endoscope that is capable of spatially encoding spectral dispersions of two light sources having frequency difference as much as a Raman shift and overlapping two laser beams on a position where a sample to be measured is placed, thereby acquiring a spatial distribution of CARS signals.Type: ApplicationFiled: November 27, 2008Publication date: July 8, 2010Applicant: Korea Research Institute of Standards & Science a government research instituteInventors: Eun Seong Lee, Jae Yong Lee, Dae Won Moon
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Publication number: 20100020318Abstract: The present invention relates to a 3-color multiplex CARS spectrometer. In the 3-color multiplex CARS spectrometer, Raman resonance is achieved for multiple molecular vibrations of a sample by the combination of a short-wavelength pump beam generated by a broadband laser light source and a long-wavelength Stokes beam generated by a stable laser light source, and another short-wavelength laser beam having a narrow linewidth is then introduced separately to serve as a probe beam that interacts with the laser-driven sample, thereby generating CARS spectral signals whose wavelength components can be resolved. Accordingly, the 3-color multiplex CARS spectrometer solves problem of the conventional 2-color multiplex CARS spectroscopy in which the wavelength decomposition of CARS signals, necessary for high spectral resolution, is not possible with broadband pump light causing the CARS spectrum distortion.Type: ApplicationFiled: December 29, 2008Publication date: January 28, 2010Applicant: Korea Research Institute of Standards and ScienceInventors: Jae Yong Lee, Eun Seong Lee, Dae Won Moon