Patents by Inventor Dae Yoon Chi
Dae Yoon Chi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931431Abstract: The present invention relates to a pharmaceutical composition for diagnosing and treating prostate cancer, capable of targeting PSMA, and a compound provided by one aspect of the present invention has a glutamine-urea-lysine compound to which a radioactive metal-coupled chelator is structurally coupled and to which an aryl group that can additionally bind to PSMA protein is coupled. Coupling between the glutamine-urea-lysine compound and the chelator includes a polar spacer so as to serve the role of reducing in vivo nonspecific coupling and exhibit an effect of being rapidly removed from vital organs, but not from prostate cancer. These characteristics lower the radiation exposure, which is caused by a therapeutic radioisotope-coupled compound, to normal tissue and organs, and thus reduce side effects. In addition, a compound that contains a phenyl group having a coupling force with albumin has an increased residence time in the blood, thereby becoming more accumulated in prostate cancer.Type: GrantFiled: March 29, 2019Date of Patent: March 19, 2024Assignee: FUTURECHEM CO., LTDInventors: Dae Yoon Chi, Byoung Se Lee, So Young Chu, Hyeon Jin Jeong, Min Hwan Kim, Kyo Chul Lee, Yong Jin Lee
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Patent number: 11306091Abstract: The present invention relates to a process for producing an organofluoro compound including [18F]fluorine, and by using a solvent represented by Formula 1 in nucleophilic fluorination reaction, an organofluoro compound may be prepared at a high yield. In addition, since the solvent has very excellent solubility for a precursor compound, the solvent is suitable for the automated synthesis of 18F-labeled radiopharmaceuticals.Type: GrantFiled: May 29, 2020Date of Patent: April 19, 2022Assignee: FUTURECHEM CO., LTDInventors: Dae Yoon Chi, Byoung Se Lee, So Young Chu, Hyeon Jin Jeong, Hyeon Seok Kim
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Publication number: 20210106701Abstract: The present invention relates to a pharmaceutical composition for diagnosing and treating prostate cancer, capable of targeting PSMA, and a compound provided by one aspect of the present invention has a glutamine-urea-lysine compound to which a radioactive metal-coupled chelator is structurally coupled and to which an aryl group that can additionally bind to PSMA protein is coupled. Coupling between the glutamine-urea-lysine compound and the chelator includes a polar spacer so as to serve the role of reducing in vivo nonspecific coupling and exhibit an effect of being rapidly removed from vital organs, but not from prostate cancer. These characteristics lower the radiation exposure, which is caused by a therapeutic radioisotope-coupled compound, to normal tissue and organs, and thus reduce side effects. In addition, a compound that contains a phenyl group having a coupling force with albumin has an increased residence time in the blood, thereby becoming more accumulated in prostate cancer.Type: ApplicationFiled: March 29, 2019Publication date: April 15, 2021Inventors: Dae Yoon CHI, Byoung Se LEE, So Young CHU, Hyeon Jin JEONG, Min Hwan KIM, Kyo Chul Lee, Yong Jin Lee
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Publication number: 20200407360Abstract: The present invention relates to a process for producing an organofluoro compound including [18F]fluorine, and by using a solvent represented by Formula 1 in nucleophilic fluorination reaction, an organofluoro compound may be prepared at a high yield. In addition, since the solvent has very excellent solubility for a precursor compound, the solvent is suitable for the automated synthesis of 18F-labeled radiopharmaceuticals.Type: ApplicationFiled: May 29, 2020Publication date: December 31, 2020Applicant: FUTURECHEM CO., LTDInventors: Dae Yoon CHI, Byoung Se LEE, So Young CHU, Hyeon Jin JEONG, Hyeon Seok KIM
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Patent number: 10870629Abstract: The present invention relates to an 18F-labelled compound, and a use thereof. The compound selectively binds to a prostate-specific membrane antigen (PSMA), and enables the acquisition of clear prostate cancer images in a short time when used in positron emission tomography (PET).Type: GrantFiled: June 18, 2018Date of Patent: December 22, 2020Assignee: FUTURECHEM CO., LTD.Inventors: Dae Yoon Chi, Byoung Se Lee, So Young Chu, Woon Jung Jung, Hyeon Jin Jeong, Min Hwan Kim, Mi Hyun Kim, Kyo Chul Lee, Yong Jin Lee, Ji Ae Park, Ran Ji Yoo, Sang Moo Lim
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Publication number: 20200207724Abstract: The present invention relates to an 18F-labelled compound, and a use thereof. The compound selectively binds to a prostate-specific membrane antigen (PSMA), and enables the acquisition of clear prostate cancer images in a short time when used in positron emission tomography (PET).Type: ApplicationFiled: June 18, 2018Publication date: July 2, 2020Inventors: Dae Yoon CHI, Byoung Se LEE, So Young CHU, Woon Jung JUNG, Hyeon Jin JEONG, Min Hwan KIM, Mi Hyun KIM, Kyo Chul LEE, Yong Jin LEE, Ji Ae PARK, Ran Ji YOO, Sang Moo LIM
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Publication number: 20190202820Abstract: The present invention relates to a process for producing an organic fluoro compound containing [18F]fluorine. The method of the present invention for producing the organic fluoro compound is not only advantageous for producing the organic fluoro compound with high yield by using the solvent represented by formula 1 for nucleophilic fluorination reaction but also suitable for automatic synthesis of 18F-labeled radiopharmaceuticals due to the excellent solubility of the precursor compound in the solvent.Type: ApplicationFiled: July 23, 2018Publication date: July 4, 2019Inventors: Dae Yoon Chi, Byoung Se Lee, Hyeon Jin Jeong, Sung Uk Yang
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Patent number: 9751844Abstract: The present invention relates to a solid precursor in the form of an organic salt, the solid precursor having a solid support, a method for manufacturing same, and an application thereof. The solid precursor of the present invention enables omission of the [18F]fluoride refining process using additional cartridge, and the use of excessive phase-transfer catalyst, and can easily remove remaining substance after reaction through the solid support inside the precursor. The solid precursor of the present invention is very appropriate for an automated synthesis device as an all-in-one system that can carry out overall process of [18F]fluorosis reaction, when used by charging in a cartridge.Type: GrantFiled: December 13, 2011Date of Patent: September 5, 2017Assignee: FUTURECHEM CO., LTD.Inventors: Dae-Yoon Chi, Byoung-Se Lee, Jae-Hak Lee, So-Young Chu, Woon-Jung Jung, Hye-Rim Kwon
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Patent number: 9550704Abstract: The present invention relates to a method for synthesizing a radiopharmaceutical using a cartridge, which makes it possible to carry out several steps of reaction required for synthesizing a radiopharmaceutical in the cartridge filled with a polymer. A method for synthesizing a radiopharmaceutical according to the present invention enables each step's reaction to be carried out with the solution confined in the cartridge so as not to flow out, thus being simplified compared to the conventional methods for synthesizing radiopharmaceuticals, and expediting the synthesis thereof.Type: GrantFiled: May 24, 2013Date of Patent: January 24, 2017Assignee: FUTURECHEM CO., LTD.Inventors: Dae Yoon Chi, Byoung Se Lee, Jae Hak Lee, So Young Chu, Woon Jung Jung
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Patent number: 9505799Abstract: The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing 18F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of a compound after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system.Type: GrantFiled: May 11, 2012Date of Patent: November 29, 2016Assignee: Futurechem Co., Ltd.Inventors: Dae-Yoon Chi, Byoung-Se Lee, Chansoo Park, Min-Hyung Lee, Hyojin Cha, Woojin Cho, Heewon Kang, Kyunghun Kim
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Patent number: 9408910Abstract: The present invention relates to an anticancer prodrug consisting of peptide of acetyl-SEQ ID NO: 1-linker-anticancer drug. The anticancer prodrug effectively provides an anticancer drug unstable in acid or base, such as doxorubicin, in a form of prodrug. Thus, the anticancer prodrug exists as a non-toxic inactive form when administered into the body, but effectively releases the anticancer drug as an active ingredient in the target area in the presence of caspase activated by radiation or UV treatment after administered into the body. Accordingly, the anticancer drug exhibits selective anticancer effects on cancer cells, thereby maximizing the therapeutic effect and minimizing the side-effects of chemotherapy.Type: GrantFiled: March 2, 2011Date of Patent: August 9, 2016Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Ju-Hee Ryu, Kwang-Meyung Kim, Ick-Chan Kwon, Kui-Won Choi, Sang-Yoon Kim, Beom-Suk Lee, Dae-Yoon Chi, Hee-Seup Kil, Hyun-Ju Sung
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Patent number: 9408911Abstract: The present invention relates to an anticancer prodrug consisting of peptide of acetyl-SEQ ID NO: 1-linker-anticancer drug. The anticancer prodrug effectively provides an anticancer drug unstable in acid and base, such as doxorubicin, in a form of prodrug. Thus, the anticancer prodrug exists as a non-toxic inactive form when administered into the body, but effectively releases the anticancer drug as an active ingredient in the target area in the presence of caspase activated by radiation or UV treatment after administered into the body. Accordingly, the anticancer drug exhibits selective anticancer effects on cancer cells, thereby maximizing the therapeutic effect and minimizing the side-effects of chemotherapy.Type: GrantFiled: December 18, 2015Date of Patent: August 9, 2016Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Ju-Hee Ryu, Kwang-Meyung Kim, Ick-Chan Kwon, Kui-Won Choi, Sang-Yoon Kim, Beom-Suk Lee, Dae-Yoon Chi, Hee-Seup Kil, Hyun-Ju Sung
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Publication number: 20160184430Abstract: The present invention relates to an anticancer prodrug consisting of peptide of acetyl-SEQ ID NO: 1-linker-anticancer drug. The anticancer prodrug effectively provides an anticancer drug unstable in acid and base, such as doxorubicin, in a form of prodrug. Thus, the anticancer prodrug exists as a non-toxic inactive form when administered into the body, but effectively releases the anticancer drug as an active ingredient in the target area in the presence of caspase activated by radiation or UV treatment after administered into the body. Accordingly, the anticancer drug exhibits selective anticancer effects on cancer cells, thereby maximizing the therapeutic effect and minimizing the side-effects of chemotherapy.Type: ApplicationFiled: December 18, 2015Publication date: June 30, 2016Applicant: Korea Institute of Science and TechnologyInventors: Ju-Hee Ryu, Kwang-Meyung Kim, Ick-Chan Kwon, Kui-Won Choi, Sang-Yoon Kim, Beom-Suk Lee, Dae-Yoon Chi, Hee-Seup Kil, Hyun-Ju Sung
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Patent number: 9254471Abstract: Method and apparatus for synthesizing an F-18 labeled radioactive pharmaceutical by labeling a precursor with an F-18 radioactive isotope, by reacting the labeled precursor to obtain a labeled pharmaceutical, by separating impurities from the labeled pharmaceutical to provide a purified labeled pharmaceutical, and by collecting the purified labeled pharmaceutical. The apparatus includes a labeling cartridge that contains the precursor, receives the isotope, and causes a labeling reaction to provide the labeled precursor; a synthesizing container that receives the labeled precursor, receives at least one reagent effective to hydrolyze the labeled precursor, and within which the labeled precursor undergoes a hydrolysis reaction to provide the labeled pharmaceutical; and a separation cartridge that receives the labeled pharmaceutical, and contains a polymer compound that separates impurities into polar compounds and nonpolar compounds to provide the purified labeled pharmaceutical.Type: GrantFiled: May 11, 2012Date of Patent: February 9, 2016Assignee: SOGANG UNIVERSITY RESEARCH FOUNDATIONInventors: Cheol-Soo Lee, Dae-Yoon Chi, Eun-Young Heo, Jong-Min Kim, Byoung-Se Lee, Hee-Seup Kil
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Patent number: 9133143Abstract: The present invention relates to (3-fluoro-2-hydroxy)propyl-functionalized aryl derivatives or to the pharmaceutically acceptable salt thereof, to a method for preparing same, and to a pharmaceutical composition containing same as active ingredients for the diagnosis or treatment of neurodegenerative brain diseases. The aryl derivatives of the present invention are (3-fluoro-2-hydroxy)propyl-functionalized to increase the polarity thereof, and therefore the drugs containing the aryl derivatives can easily permeate into the cerebrovascular membrane, thus increasing the effectiveness of the drugs. As the aryl derivatives of the present invention strongly bind to ?-amyloid, the aryl derivatives, when labeled with radioisotope, can be used as a diagnostic agent for non-invasively diagnosing early Alzheimer's disease.Type: GrantFiled: September 14, 2010Date of Patent: September 15, 2015Assignee: FUTURECHEM CO., LTD.Inventors: Dae-Yoon Chi, Byoung-Se Lee, Sirion Uthaiwan, So-Young Chu, Yu-Jin Bae, Chansoo Park, Dae-Hyuk Moon, Jin-Sook Ryu, Jae-Seung Kim, Seung-Jun Oh
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Publication number: 20150232392Abstract: The present invention relates to a method for synthesizing a radiopharmaceutical using a cartridge, which makes it possible to carry out several steps of reaction required for synthesizing a radiopharmaceutical in the cartridge filled with a polymer. A method for synthesizing a radiopharmaceutical according to the present invention enables each step's reaction to be carried out with the solution confined in the cartridge so as not to flow out, thus being simplified compared to the conventional methods for synthesizing radiopharmaceuticals, and expediting the synthesis thereof.Type: ApplicationFiled: May 24, 2013Publication date: August 20, 2015Inventors: Dae Yoon Chi, Byoung Se Lee, Jae Hak Lee, So Young Chu, Woon Jung Jung
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Patent number: 9000037Abstract: This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.Type: GrantFiled: April 30, 2012Date of Patent: April 7, 2015Assignee: Piramal Imaging SAInventors: Christina Hultsch, Michael Harre, Filip Novak, Mathias Berndt, Matthias Friebe, Heribert Schmitt-Willich, Dae Yoon Chi, Byoung Se Lee, Sang Don Park
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Publication number: 20150087868Abstract: The present invention relates to an apparatus for synthesizing F-18 labeled radioactive pharmaceutical. The apparatus for synthesizing F-18 labeled radioactive pharmaceutical includes an F-18 radioactive isotope supplier, a reagent supplier, a polymer precursor cartridge, a first heating unit, a polymer compound cartridge, a synthesizing container, a second heating unit, a water liquid container, a transmitting gas supplier, a cleansing liquid supplier, a connection tube, a plurality of control valves, and a controller.Type: ApplicationFiled: May 11, 2012Publication date: March 26, 2015Applicant: SOGANG UNIVERSITY RESEARCH FOUNDATIONInventors: Cheol-Soo Lee, Dae-Yoon Chi, Eun-Young Heo, Jong-Min Kim, Byoung-Se Lee, Hee-Seup Kil
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Patent number: 8841085Abstract: Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.Type: GrantFiled: August 27, 2009Date of Patent: September 23, 2014Assignees: Korea Institute of Science and Technology, The Asan Foundation, Futurechem Co., Ltd.Inventors: Ick-Chan Kwon, Kui-Won Choi, Kwang-Meyung Kim, In-Chan Youn, Seul-Ki Lee, Kyeong-Soon Park, Dae-Hyuk Moon, Dae-Yoon Chi, Seung-Jin Lee, Seung-Jae Myung
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Publication number: 20140243532Abstract: This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.Type: ApplicationFiled: April 30, 2012Publication date: August 28, 2014Applicant: PIRAMAL IMAGING SAInventors: Christina Hultsch, Michael Harre, Filip Novak, Mathias Berndt, Matthias Friebe, Heribert Schmitt-Willich, Dae Yoon Chi, Byoung Se Lee, Sang Don Park