Abstract: The present invention relates to an anticancer prodrug consisting of peptide of acetyl-SEQ ID NO: 1-linker-anticancer drug. The anticancer prodrug effectively provides an anticancer drug unstable in acid or base, such as doxorubicin, in a form of prodrug. Thus, the anticancer prodrug exists as a non-toxic inactive form when administered into the body, but effectively releases the anticancer drug as an active ingredient in the target area in the presence of caspase activated by radiation or UV treatment after administered into the body. Accordingly, the anticancer drug exhibits selective anticancer effects on cancer cells, thereby maximizing the therapeutic effect and minimizing the side-effects of chemotherapy.

Abstract: 2-arylbenzothiophene derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as an active ingredient. Since the 2-arylbenzothiophene derivatives of Formula 1 have a relatively high binding affinity for ?-amyloid, they can be used as diagnostic reagents for diagnosing Alzheimer's disease at an early stage by non-invasive techniques when they are labeled with radioisotopes: wherein R1-R4, V, W, X, Y and Z are as defined in the Detailed Descript of the specification. Further, when the pharmaceutical composition containing the 2-arylbenzothiophene derivative binds with a low-molecular weight ?-amyloid peptide binding compound, generation of malignant high-molecular weight ?-amyloid deposits is minimized. Accordingly, the pharmaceutical composition can be used as a therapeutic agent of degenerative brain disease such as Alzheimer's disease.

Abstract: The present invention provides novel and advantageous processes for preparing and purifying pharmaceuticals The processes comprise a nucleophilic reaction wherein a modified leaving group LM, which has increased lipophilicity, of a vector in a nucleophilic reaction which offers a convenient and time-saving way to purify the product from non-reacted precursors vector-LM and by-products LM.

Abstract: The present invention relates to (3-fluoro-2-hydroxy)propyl-functionalized aryl derivatives or to the pharmaceutically acceptable salt thereof, to a method for preparing same, and to a pharmaceutical composition containing same as active ingredients for the diagnosis or treatment of neurodegenerative brain diseases. The aryl derivatives of the present invention are (3-fluoro-2-hydroxy)propyl-functionalized to increase the polarity thereof, and therefore the drugs containing the aryl derivatives can easily permeate into the cerebrovascular membrane, thus increasing the effectiveness of the drugs. As the aryl derivatives of the present invention strongly bind to ?-amyloid, the aryl derivatives, when labeled with radioisotope, can be used as a diagnostic agent for non-invasively diagnosing early Alzheimer's disease.

Abstract: Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.

Abstract: A continuous variable valve lift device includes a valve, which opens/closes a channel by means of reciprocation, a control shaft, which is mounted so as to be able to move toward or away from a reciprocation central axis of the valve, a pivotable shoe, which is pivotably coupled to the control shaft, includes a cam insertion part in a recess or through-hole shape and a slide face slidably contacting an end of the valve, and reciprocates the valve when pivoted, and a drive cam, which comes into contact with an inner wall of the cam insertion part, and pivots the pivotable shoe. Thereby, the continuous variable valve lift device can freely adjust a lift amount and a lift time of the valve without changing positions of the drive cam and camshaft, and thus be easily applied to an existing engine.

Abstract: The present invention provides novel and advantageous processes for preparing and purifying chemical compounds such as pharmaceuticals. The processes comprise a nucleophilic substitution reaction with a moiety X wherein the leaving group L of a substrate S in the reaction is covalently attached to a purification moiety M. This concept offers a convenient and lime-saving way to purity the desired product S-X from non-reacted precursors S-L-M and by-products L-M.

Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of primary or secondary organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with primary or secondary alkyl halide or primary or secondary alkyl sulfonate in the presence of alcohol of Chemical Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

Abstract: 2-arylbenzothiophene derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as an active ingredient. Since the 2-arylbenzothiophene derivatives of Formula 1 have a relatively high binding affinity for ?-amyloid, they can be used as diagnostic reagents for diagnosing Alzheimer's disease at an early stage by non-invasive techniques when they are labeled with radioisotopes: wherein R1-R4, V, W, X, Y and Z are as defined in the Detailed Descript of the specification. Further, when the pharmaceutical composition containing the 2-arylbenzothiophene derivative binds with a low-molecular weight ?-amyloid peptide binding compound, generation of malignant high-molecular weight ?-amyloid deposits is minimized. Accordingly, the pharmaceutical composition can be used as a therapeutic agent of degenerative brain disease such as Alzheimer's disease.

Abstract: Provided are 7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline derivatives and synthesis methods thereof. The compounds significantly inhibit the production of nitrogen monoxide (NO) and superoxide in an activated microglial cell and expressions of TNF-?, IL-1? inducive NO synthase and cyclooxygenase-2 genes. They also prevent NF-kB shift to a nucleus, decrease reactive oxygen species (ROS), inhibit expression of GTP cyclohydrolase I gene and over-production of tetrahydrobiopterin (BH4), and protect dopaminergic neurons from injury due to activated microglial cells. Consequently, the compounds are effective in treating inflammatory and neurodegenerative diseases.

Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [18F]florbetaben or [18F]AV-45 having <Chemistry Formula 11> and <Chemistry Formula 12>, respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

Abstract: A continuous variable valve lift device includes a valve, which opens/closes a channel by means of reciprocation, a control shaft, which is mounted so as to be able to move toward or away from a reciprocation central axis of the valve, a pivotable shoe, which is pivotably coupled to the control shaft, includes a cam insertion part in a recess or through-hole shape and a slide face slidably contacting an end of the valve, and reciprocates the valve when pivoted, and a drive cam, which comes into contact with an inner wall of the cam insertion part, and pivots the pivotable shoe. Thereby, the continuous variable valve lift device can freely adjust a lift amount and a lift time of the valve without changing positions of the drive cam and camshaft, and thus be easily applied to an existing engine.

Abstract: A backlight assembly includes a plurality of lamps, a first reflecting plate and an optical member. The lamps are disposed substantially parallel with each other and generate light. The bottom reflecting plate is disposed under the lamps to reflect the light. The first reflecting plate is disposed over the lamps to transmit and reflect the light and has a plurality of penetration holes for transmitting the light. The optical member is disposed over the first reflecting plate. The formation density of the penetration holes increases as a position of the penetration holes approaches an intermediate region between adjacent lamps from a region corresponding to a position of the lamps.

Abstract: A backlight assembly having improved strength and a display device having the backlight assembly are provided. The backlight assembly includes a light source supplying light and a fixing member receiving the light source. A deflection preventing portion having a predetermined width is formed on a surface of the fixing member in a direction crossing a diagonal on the surface of the fixing member.

Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry (FIG. 1) as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

Abstract: Disclosed are a chassis, and a backlight unit and a liquid crystal display including the chassis. The chassis includes a first chassis member that includes a first base plate, a first wall extending from the first base plate in a first direction, and a first cover plate extending from the first wall and facing the first base plate. The chassis also includes a second chassis member.

Abstract: A liquid crystal display device, includes a liquid crystal panel, a light guide plate which is provided behind the liquid crystal panel and comprises an exit surface facing the liquid crystal panel, a reflecting surface opposite the exit surface, a pair of incident surfaces opposite to each other, and a pair of side surfaces opposite to each other, a pair of light sources provided along the respective incident surfaces of the light guide plate, and a pair of cover members, each of the cover members comprises a first part accommodating one of the light sources with one of the incident surfaces cover member and a second part extending from the first part and facing the reflecting surface of the light guide plate, and over which the liquid crystal panel is seated.

Abstract: A liquid crystal display includes an upper cover comprising a display window, a liquid crystal panel provided behind the upper cover, a light guide plate provided behind the liquid crystal panel, a light source unit provided along a side of the light guide plate, and a light source cover which comprises a reflection unit that is joined to the upper cover and reflects light emitted from the light source unit to the light guide, and a support unit that extends from a side of the reflection unit to a rear of the light guide plate.

Abstract: In a backlight assembly, a liquid crystal display (“LCD”) apparatus including the backlight assembly and a method for manufacturing the backlight assembly, the backlight assembly includes first, second, third and fourth lamps. The first to fourth lamps respectively face first to fourth side surfaces of a light-guide plate. Each include an input and an output terminal. The output terminals of the first and second lamps and of the third and fourth lamps, and the input terminals of the first and fourth lamps and of the second and third lamps, are adjacent to each other. A pair of the output terminals of the first and second lamps or the third and fourth lamps is connected to each other, so that the pair of lamps is arranged in an L-shape. The pair of the output terminals may be fed back to each input terminal, or grounded to a receiving container.

Abstract: A backlight assembly includes a plurality of lamps, a first reflecting plate and an optical member. The lamps are disposed substantially parallel with each other and generate light. The bottom reflecting plate is disposed under the lamps to reflect the light. The first reflecting plate is disposed over the lamps to transmit and reflect the light and has a plurality of penetration holes for transmitting the light. The optical member is disposed over the first reflecting plate. The formation density of the penetration holes increases as a position of the penetration holes approaches an intermediate region between adjacent lamps from a region corresponding to a position of the lamps.