Patents by Inventor Dafang Wu

Dafang Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transport of basic fibroblast growth factor across the blood brain barrier
    Publication number: 20080154022
    Abstract: Compositions and methods for increasing the receptor mediated transport of basic fibroblast growth factor (bFGF) across the blood brain barrier (BBB). The bFGF is conjugated to a BBB targeting agent using either avidin-biotin technology or genetic engineering. The bFGF conjugate was found to cross the BBB at substantially increased rates while still retaining biological activity. In addition, uptake of the bFGF conjugate by non-brain tissue and organs was limited. The bFGF conjugate may be injected intravenously to provide neuroprotection in patients suffering from cerebral stroke.
    Type: Application
    Filed: June 1, 2007
    Publication date: June 26, 2008
    Applicant: The Regents of the University of California
    Inventors: Dafang Wu, William M. Pardridge
  • Transport of basic fibroblast growth factor across the blood brain barrier
    Publication number: 20040102369
    Abstract: Compositions and methods for increasing the receptor mediated transport of basic fibroblast growth factor (bFGF) across the blood brain barrier (BBB). The bFGF is conjugated to a BBB targeting agent using either avidin-biotin technology or genetic engineering. The bFGF conjugate was found to cross the BBB at substantially increased rates while still retaining biological activity. In addition, uptake of the bFGF conjugate by non-brain tissue and organs was limited. The bFGF conjugate may be injected intravenously to provide neuroprotection in patients suffering from cerebral stroke.
    Type: Application
    Filed: November 27, 2002
    Publication date: May 27, 2004
    Applicant: The Regents of the University of California
    Inventors: Dafang Wu, William M. Pardridge