Patents by Inventor Dahai Luo

Dahai Luo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunomodulatory small hairpin RNA molecules
    Patent number: 11499157
    Abstract: The present invention generally relates to specific immune-modulatory RNA species that have a small hairpin structure (shRNA), and that can bind to retinoic acid inducible gene I receptor (RIG-I). In particular, said RNA species comprise a nucleotide insertion to create a kink in the stem region. Also encompassed are compositions comprising such shRNA, for use as antiviral or anticancer medication, or as adjuvants in vaccine.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: November 15, 2022
    Assignees: Nanyang Technological University, Agency for Science, Technology and Research
    Inventors: Dahai Luo, Katja Fink, Hui Yee Yong, Chin Yong Victor Ho
  • Compositions and Methods for Treating, Ameliorating, and/or Preventing Viral Infections
    Publication number: 20210102209
    Abstract: The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5?-triphosphate or a 5?-diphosphate.
    Type: Application
    Filed: December 9, 2020
    Publication date: April 8, 2021
    Inventors: Anna Marie Pyle, Andrew Kohlway, Dahai Luo, David Rawling, Akiko Iwasaki, Tianyang Mao
  • Interferon production using short RNA duplexes
    Patent number: 10947543
    Abstract: The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5? triphosphate or a 5? diphosphate.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 16, 2021
    Assignee: Yale University
    Inventors: Anna Marie Pyle, Andrew Kohlway, Dahai Luo, David Rawling, Akiko Iwasaki
  • Interferon Production Using Short RNA Duplexes
    Publication number: 20210054380
    Abstract: The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5? triphosphate or a 5? diphosphate.
    Type: Application
    Filed: August 25, 2020
    Publication date: February 25, 2021
    Inventors: Anna Marie Pyle, Andrew Kohlway, Dahai Luo, David Rawling, Akiko Iwasaki
  • IMMUNOMODULATORY SMALL HAIRPIN RNA MOLECULES
    Publication number: 20210000856
    Abstract: The present invention generally relates to specific immune-modulatory RNA species that have a small hairpin structure (shRNA), and that can bind to retinoic acid inducible gene I receptor (RIG-I). In particular, said RNA species comprise a nucleotide insertion to create a kink in the stem region. Also encompassed are compositions comprising such shRNA, for use as antiviral or anticancer medication, or as adjuvants in vaccine.
    Type: Application
    Filed: January 17, 2019
    Publication date: January 7, 2021
    Inventors: Dahai Luo, Katja Fink, Hui Yee Yong, Chin Yong Victor Ho
  • Interferon Production Using Short RNA Duplexes
    Publication number: 20160046943
    Abstract: The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5? triphosphate or a 5? diphosphate.
    Type: Application
    Filed: March 13, 2014
    Publication date: February 18, 2016
    Inventors: Anna Marie Pyle, Andrew Kohlway, Dahai Luo