Patents by Inventor Dahui Liu

Dahui Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for preparing a polymeric compound
    Patent number: 8354556
    Abstract: The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: January 15, 2013
    Assignee: PolyMedix, Inc.
    Inventors: Robert W. Kavash, Haizhong Tang, Carol Mulrooney, Dahui Liu
  • Polycationic Compounds And Uses Thereof
    Publication number: 20120322878
    Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.
    Type: Application
    Filed: June 21, 2012
    Publication date: December 20, 2012
    Applicant: POLYMEDIX, INC.
    Inventors: Shaker Mousa, Dahui Liu
  • Synthetic mimetics of host defense and uses thereof
    Patent number: 8278309
    Abstract: The present invention provides arylamide compounds and methods of making and using them as antibiotics.
    Type: Grant
    Filed: October 26, 2009
    Date of Patent: October 2, 2012
    Assignee: PolyMedix, Inc.
    Inventors: William F. DeGrado, Dahui Liu, Richard W. Scott, Yongjiang Xu, Haizhong Tang, Bozena Korczak
  • Facially Amphiphilic Polyaryl and Polyarylalkynyl Polymers and Oligomers and Uses Thereof
    Publication number: 20120202887
    Abstract: The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.
    Type: Application
    Filed: February 3, 2012
    Publication date: August 9, 2012
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: William F. DeGRADO, Dahui Liu, Gregory N. Tew, Michael L. Klein
  • Facially amphiphilic polymers and oligomers and uses thereof
    Patent number: 8236800
    Abstract: The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: August 7, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: William F. DeGrado, Gregory N. Tew, Michael L. Klein, Dahui Liu, Jing Yuan, Sungwook Choi
  • Polycationic compounds and uses thereof
    Patent number: 8232428
    Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: July 31, 2012
    Assignee: PolyMedix,Inc.
    Inventors: Shaker Mousa, Dahui Liu
  • Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof
    Patent number: 8222456
    Abstract: The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: July 17, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: William F. DeGrado, Dahui Liu, Gregory N. Tew, Michael L. Klein
  • Polycationic compounds and uses thereof
    Patent number: 8129566
    Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: March 6, 2012
    Assignee: PolyMedix, Inc.
    Inventors: Shaker Mousa, Dahui Liu
  • Anti-Heparin Compounds
    Publication number: 20110178104
    Abstract: The present invention provides compounds and methods for antagonizing the anticoagulant effect of an anticoagulant agent that is selected from UFH, LMWH, and a heparin/LMWH derivative in a patient comprising administering to the patient a compound of the invention or a salt thereof, or a composition comprising the same.
    Type: Application
    Filed: January 5, 2011
    Publication date: July 21, 2011
    Applicant: POLYMEDIX INC.
    Inventors: Richard W. Scott, Dahui Liu, Robert W. Kavash, Trevor Young, Michael J. Costanzo, Carol Ann Mulrooney
  • Polycationic Compounds And Uses Thereof
    Publication number: 20110124664
    Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.
    Type: Application
    Filed: December 17, 2010
    Publication date: May 26, 2011
    Applicant: POLYMEDIX, INC.
    Inventors: Shaker Mousa, Dahui Liu
  • Processes For Preparing A Polymeric Compound
    Publication number: 20110098498
    Abstract: The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 21, 2010
    Publication date: April 28, 2011
    Applicant: POLYMEDIX, INC.
    Inventors: Robert W. Kavash, Haizhong Tang, Carol Mulrooney, Dahui Liu
  • Polycationic Compounds And Uses Thereof
    Publication number: 20100298344
    Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.
    Type: Application
    Filed: March 10, 2010
    Publication date: November 25, 2010
    Inventors: Shaker Mousa, Dahui Liu
  • Antimicrobial Molecules For Treating Multi-Drug Resistant And Extensively Drug Resistant Strains Of Mycobacterium
    Publication number: 20100144761
    Abstract: The present invention provides methods of inhibiting the growth of Mycobacterium species or treating an animal having a Mycobacterium infection (including multi-drug resistance strains and extensively drug resistant strains) by administering a compound of the invention, a salt thereof, or a composition comprising the same.
    Type: Application
    Filed: December 9, 2009
    Publication date: June 10, 2010
    Inventors: Richard W. Scott, Dahui Liu
  • Synthetic Mimetics Of Host Defense And Uses Thereof
    Publication number: 20100105703
    Abstract: The present invention provides arylamide compounds and methods of making and using them as antibiotics.
    Type: Application
    Filed: October 26, 2009
    Publication date: April 29, 2010
    Applicant: POLYMEDIX, INC.
    Inventors: William F. DeGrado, Dahui Liu, Richard W. Scott, Yongjiang Xu, Haizhong Tang, Bozena Korczak
  • Anti-Malarial Compounds
    Publication number: 20100081665
    Abstract: The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
    Type: Application
    Filed: July 28, 2009
    Publication date: April 1, 2010
    Inventors: Richard W. Scott, Doron Greenbaum, Dahui Liu, Xiaodong Fan, Yongjiang Xu, Haizhong Tang, Ehab Khalil
  • Facially amphiphilic polymers and oligomers and uses thereof
    Publication number: 20080176807
    Abstract: The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 24, 2008
    Inventors: William F. DeGrado, Gregory N. Tew, Michael L. Klein, Dahui Liu, Jing Yuan, Sungwook Choi
  • Facially amphiphilic polymers as anti-infective agents
    Patent number: 7173102
    Abstract: Facially amphiphilic polymers and articles made therefrom having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a method to identify and optimize the facial amphiphilicity of polyamide, polyester, polyurea, polyurethane, polycarbonate and polyphenylene polymers. Utility as a contact disinfectant is disclosed.
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: February 6, 2007
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: William F. DeGrado, Gregory N. Tew, Michael L. Klein, Dahui Liu, Jing Yuan
  • Facially amphilic polymers and oligomers and uses thereof
    Publication number: 20060041023
    Abstract: The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
    Type: Application
    Filed: March 17, 2004
    Publication date: February 23, 2006
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: William DeGrado, Gregory Tew, Michael Klein, Dahui Liu, Jing Yuan, Sungwook Choi
  • Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof
    Publication number: 20050287108
    Abstract: The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.
    Type: Application
    Filed: January 21, 2005
    Publication date: December 29, 2005
    Inventors: William DeGrado, Dahui Liu, Gregory Tew, Michael Klein
  • Facially amphiphilic polymers as anti-infective agents
    Publication number: 20040185257
    Abstract: Facially amphiphilic polymers and articles made therefrom having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a method to identify and optimize the facial amphiphilicity of polyamide, polyester, polyurea, polyurethane, polycarbonate and polyphenylene polymers. Utility as a contact disinfectant is disclosed.
    Type: Application
    Filed: May 11, 2004
    Publication date: September 23, 2004
    Inventors: William F. DeGrado, Gregory N. Tew, Michael L. Klein, Dahui Liu, Jing Yuan